Blood Levels of Sevoflurane and Desflurane

March 2, 2018 updated by: ebru biricik, Cukurova University

Blood Levels of Sevoflurane and Desflurane During One Lung Ventilation

16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Investigator aimed to assess blood level of sevoflurane and desflurane during two lung ventilation and one lung ventilation. The investigators will use Gas Chromatography for define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential blood samples will be taken from both arterial and central venous canula at the same time point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation second blood samples will be taken at the 10. minutes of one lung ventilation. After than at the interval of 10 minutes, collection of blood samples both arterial and central venous will be continue.

All collection will assess with gas chromatography.

Study Type

Observational

Enrollment (Actual)

16

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
    • In The USA Or Canada, Please Select...
      • Adana, In The USA Or Canada, Please Select..., Turkey, 01380
        • Ebru Biricik

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

25 years to 65 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

16 patients with ASA I-III who undergo thoracotomy or abdominal surgery

Description

Inclusion Criteria: ASA I-II patients

  • Who undergo thoracotomy or abdominal surgery

Exclusion Criteria:

  • ASA IV and up patients
  • Patients who taken inotropic agent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
two lung ventilation of Sevoflurane
In GroupSa, 1,5 % sevoflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute.
Drug: Sevoflurane
Measurement of blood desflurane level during one lung ventilation
Other Names:
  • Blood sevoflurane level
one lung ventilation of Sevoflurane
In GroupSa, 1,5 % sevoflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started.
Drug: Sevoflurane
Measurement of blood desflurane level during one lung ventilation
Other Names:
  • Blood sevoflurane level
two lung ventilation of Desflurane
In GroupSa, 6 % desflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute.
Drug: Desflurane
Measurement of blood desflurane level during one lung ventilation
Other Names:
  • Blood desflurane level
one lung ventilation of desflurane
In GroupSa, 6 % desflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started.
Drug: Desflurane
Measurement of blood desflurane level during one lung ventilation
Other Names:
  • Blood desflurane level

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Measurement of blood levels of Sevoflurane and Desflurane
Time Frame: from 40th minute to the end of the operation
Data collections will be ensured from arterial and venous blood sample and than samples will be assessed with gas chromatography and blood sevoflurane and desflurane level will be measured. Blood samples will take every 10 minutes. Only blood levels of sevoflurane and desflurane will be assessed.
from 40th minute to the end of the operation

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
determine of ventilation-perfusion mismatch with p(A-a)O2
Time Frame: from 40th minute to the end of the one lung ventilation
During one lung ventilation, p(a-A)O2 will be assessed with arterial blood analyses
from 40th minute to the end of the one lung ventilation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cukurova University

Investigators

  • Principal Investigator: Ebru Biricik, MD, Çukurova university

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2016

Primary Completion (ACTUAL)

December 1, 2017

Study Completion (ACTUAL)

December 1, 2017

Study Registration Dates

First Submitted

December 27, 2016

First Submitted That Met QC Criteria

January 6, 2017

First Posted (ESTIMATE)

January 10, 2017

Study Record Updates

Last Update Posted (ACTUAL)

March 5, 2018

Last Update Submitted That Met QC Criteria

March 2, 2018

Last Verified

November 1, 2017

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • One lung ventilation

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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