The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes

The Effect of β-hydroxy-β-methylbutyrate (HMB) Supplementation on Physical Capacity and Body Composition in Trained Athletes

The purpose of this study was to verify the effect of 12-week with β-hydroxy-β-methylbutyrate (HMB) and a placebo (PLA) supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Study Overview

• Status: Completed
• Conditions: Supplementation; Sport; Supplements
• Intervention / Treatment: Dietary supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation

Detailed Description

The effect of HMB supplementation is of great interest in sport. In view of the inconclusive character of the results of the studies conducted to date and of a relatively low number of studies investigating the effectiveness of HMB supplementation over a longer period on a large population of trained athletes, the aim of this study was to verify the effect of 12-week with HMB and a placebo supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

• Study Type: Interventional
• Enrollment (Actual): 58
• Phase: Phase 3

Contacts and Locations

Study Locations

• Poland
  • Wielkopolska
    • Poznan, Wielkopolska, Poland, 60-624
      • Poznan University of Life Sciences, ul.Wojska Polskiego 31

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 17 years to 40 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• written consent to participate,
• male
• a current medical clearance to practice sports,
• training experience: at least 5 years,
• minimum of 6 workout sessions a week (minimum 3 in the practiced sports discipline).

Exclusion Criteria:

• current injury,
• any health-related contraindication,
• declared general feeling of being unwell,
• unwilling to follow the study protocol.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: β-hydroxy-β-methylbutyrate (HMB); Group taking oral supplementation with calcium salt of β-hydroxy-β-methylbutyric acid produced by Olimp Laboratories. A single capsule contained 1250 mg Ca-HMB, which corresponds to 1000 mg of β-hydroxy-β-methylbutyrate. Interventions: The experimental procedure for each athlete included a 12-week HMB supplementation - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced.	Dietary supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation
Placebo Comparator: Placebo (maltodextrin); Group taking oral supplementation with placebo (maltodextrin). A single capsule contained 1000 mg of maltodextrin. Interventions: The experimental procedure for each athlete included a 12-week placebo administration - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced.	Dietary supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes of body composition indices after HMB supplementation	Analysis of the fat mass and fat free mass	Baseline and after 12 weeks
Changes of body composition indices after placebo treatment	Analysis of the fat mass and fat free mass	Baseline and after 12 weeks
Changes of aerobic capacity after HMB supplementation		Baseline and after 12 weeks
Changes of aerobic capacity after placebo treatment		Baseline and after 12 weeks
Changes of anaerobic capacity after HMB supplementation		Baseline and after 12 weeks
Changes of anaerobic capacity after placebo treatment		Baseline and after 12 weeks
Changes of creatine kinase and lactate dehydrogenase activity in blood after HMB supplementation		Baseline and after 12 weeks
Changes of creatine kinase and lactate dehydrogenase activity in blood after placebo treatment		Baseline and after 12 weeks
Changes of testosterone, cortisol and lactate levels in blood after HMB supplementation		Baseline and after 12 weeks
Changes of testosterone, cortisol and lactate levels in blood after placebo treatment		Baseline and after 12 weeks

Secondary Outcome Measures

Outcome Measure	Time Frame
Statistical evaluation of the significance of differences between the changes in aerobic capacity indices	1 year
Statistical evaluation of the significance of differences between the changes in body composition (fat mass and fat free mass)	1 year
Statistical evaluation of the significance of differences between the changes in anaerobic capacity indices	1 year
Statistical evaluation of the significance of differences between the changes in creatine kinase and lactate dehydrogenase activity and testosterone, cortisol and lactate levels in blood	1 year

Collaborators and Investigators

• Sponsor: Poznan University of Medical Sciences
• Collaborators: National Science Centre, Poland; Poznan University of Life Sciences
• Investigators: Study Chair: Jan Jeszka, Professor, Department of Hygiene and Human Nutrition, Poznan University of Life Sciences, Poznan, Poland

Study record dates

Study Major Dates

• Study Start: January 1, 2010
• Primary Completion (Actual): February 1, 2014
• Study Completion (Actual): February 1, 2014

Study Registration Dates

• First Submitted: January 11, 2017
• First Submitted That Met QC Criteria: January 18, 2017
• First Posted (Estimate): January 23, 2017

Study Record Updates

• Last Update Posted (Estimate): January 23, 2017
• Last Update Submitted That Met QC Criteria: January 18, 2017
• Last Verified: January 1, 2017

More Information

Terms related to this study

• Keywords: Adaptation; Training support; β-hydroxy-β-methylbutyric acid; Sport supplements
• Other Study ID Numbers: NN312262340

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided
• IPD Plan Description: Shared data will be exclusively related to the level recorded indicators (body composition, aerobic and anaerobic capacity indicators, levels of biochemical markers), without personal data. The data obtained will be attached to scientific publications, depending on the requirements of the journal