- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03042247
Prospective Comparison Between FDG-PET/MR and FDG-PET/CT in Classical Hodgkin Lymphoma and DLBC Non-Hodgkin Lymphoma
Prospective Comparison Between FDG-positron Emission Tomography (FDG-PET)/Magnetic Resonance and FDG-PET/Computed Tomography for Staging, Interim Assessment and Restaging in Classical Hodgkin Lymhoma and DLBC Non-Hodgkin Lymphoma
Study Overview
Status
Intervention / Treatment
Detailed Description
All patients diagnosed with classical Hodgkin lymphoma and diffuse large B-cell non-Hodgkin lymphoma that meet the inclusion criteria will be enrolled in the study. They will undergo an FDG-PET/CT for defining the staging and the therapeutic strategy. PET/MRI scans will be performed immediately upon completion of the PET/contrast-enhanced CT study and FDG tracer will be injected before the PET/CT exam and PET/MRI acquisitions will be practiced using the residual activity of the tracer. All patients will have to provide their informed consent in order to participate in the study.
The combined assessment FDG-PET/CT and FDG-PET/MRI will be performed at diagnosis for staging, at the interim evaluation for early assessment of treatment response after 2 cycles of chemotherapy and finally the post-chemotherapy re-staging. The enrollment period is 24 months for a total of 60 patients with Hodgkin lymphoma and 60 with DLBC non Hodgkin lymphoma.
Patients enrolled in the study will be followed for the diagnostic/therapeutic program at the Hematology Department of Federico II University of Naples, while the FDG-PET/CT and FDG-PET/MRI examinations will be carried out at the IRCSS SDN of Naples. The acquired images will be evaluated by a panel of experienced radiologists and nuclear physicians at the IRCSS SDN Naples.
The results obtained from the examination MRI will not modify in any way the clinical therapeutic choices in the planned chemotherapy for the patient, who will not receive additional radiations. This prospective pilot study will be conducted after approval by the Ethics Committee; each patient will sign an appropriate informed consent.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Roberta Della Pepa, MD
- Phone Number: +390817462037
- Email: roberta.dellapepa@unina.it
Study Locations
-
-
-
Naples, Italy, 80131
- Recruiting
- Prof Marco Picardi
-
Contact:
- Roberta Della Pepa, MD
- Phone Number: +390817462037
- Email: roberta.dellapepa@unina.it
-
Napoli, Italy, 80131
- Recruiting
- Prof Marco Picardi - Hematology - AOU FEDERICO II
-
Contact:
- Roberta Della Pepa, MD
- Phone Number: +390817462037
- Email: roberta.dellapepa@unina.it
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Histologically confirmed diagnosis of classical Hodgkin lymphoma and diffuse large B-cell non-Hodgkin lymphoma;
- Age ≥18 years;
- The need of anti-neoplastic treatment;
- Written informed consent;
Exclusion Criteria:
- Carriers of cardiac pacemakers;
- Carriers of metal mesh implants, tissue expanders (breast);
- Holders of metal implants, cochlear implants and stapedial prostheses, plates or screws, wires, nails, spinal-column distractors, ferromagnetic vascular clips, mechanical heart valves, Swan-Ganz catheter, endocorporal electrodes, neurostimulators, vascular filters, stents and metal spirals that they do not know the characteristics (the manufacturer, type and date of implant) and/or secure magnetic compatibility;
- Holders of metal fragments in the eye, visceral or intracranial;
- Tattoo holders executed by less than 6 months;
- Claustrophobic patients;
- Pregnant patients;
- Patients with uncontrolled diabetes mellitus;
- Patients who do not provide written informed consent to the study.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Hodgkin lymphoma patients
Hodgkin lymphoma patients with confirmed histological diagnosis
|
Combined assessment with FDG PET/TC and PET/MRI
|
DLBC non Hodgkin lymphoma patients
DLBC non Hodgkin lymphoma patients with confirmed histological diagnosis
|
Combined assessment with FDG PET/TC and PET/MRI
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Diagnostic accuracy in terms of sensitivity and specificity of FDG-PET/MRI in the staging and post-chemotherapy revaluation
Time Frame: 1 year
|
Evaluate the diagnostic accuracy in terms of sensitivity and specificity of FDG-PET/MRI in the staging and post-chemotherapy revaluation (early treatment response after 2 cycles of chemotherapy and final assessment) in patients with classical Hodgkin lymphoma and diffuse large B-cell non-Hodgkin lymphoma, as compared to conventional assessment by FDG PET/ contrast-enhanced CT
|
1 year
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Fabrizio Pane, Prof, Hematology - AOU Federico II - Naples - Italy
- Study Director: Marco Picardi, Prof, Hematology - AOU Federico II - Naples - Italy
- Study Chair: Andrea Soricelli, Prof, IRCSS SDN - Naples - Italy
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- FDGMR-LIN
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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