Circadian System Heritability Assessed in Free Living Conditions (MTR)

Circadian System Heritability Assessed in Free Living Conditions in a Twin Mediterranean Population

The purpose of this investigation is to assess the role of the genetic and environmental factor on circadian system, in free living conditions by the use of a female twin population. With the results from this study, the investigators expect to advance in the understanding of the role of the endogenicity of the circadian system variables such as temperature, activity, sleep and timing of food intake as the main cause of the coincidence of the rhythms. However, the investigators expected that some parameters are still dependent on environment to a relevant extent and, hence, amenable to change through external interventions.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Other: Chronobiological status of the subjects

Detailed Description

Twin studies are a classic in the analysis of the relative contribution of genetic and environmental factors to behavior and other phenotypes. These models are most often used to separate genetic from environmental causes in the family resemblance methodology. These models based on twins have been previously carried out in chronobiology. In fact, during the years 1993 and 1994, Paul Linkowski et al., performed two relevant studies on the circadian system to analyze the relative contributions of hereditary and/or environmental factors of cortisol secretion and blood pressure, respectively, and concluded that genetic factors control some of the characteristics of cortisol and diastolic blood pressure circadian rhythmicity. The heritability of other circadian markers has also demonstrated such as morningness- eveningness (44%), sleep-related variables have also pointed to a relevant role of genetics with heritability estimates of sleep duration between 17% and 55%. However, to the investigators knowledge, the heritability of other relevant chronobiological markers, measured in free living conditions such as body temperature, actigraphy and sleep has not been studied.

These goals will be achieved through a specific approach:

• Observational (Aim 1): To study the potential effect of the genetic and environmental factor in the circadian system health in order to improve the chronobiological therapies in the clinical practice (n=106).

• Study Type: Observational
• Enrollment (Actual): 106

Contacts and Locations

Study Locations

• Spain
  • Murcia, Spain, 30100
    • Juan Ramón

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 70 years (Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: Female

• Sampling Method: Non-Probability Sample

Study Population

All participants are voluntarily in the Murcia Twin Register in Spain. All participants are from the Spanish city of Murcia, located on the Southeast coast of the Mediterranean Sea.

Description

IInclusion Criteria:

• Body Mass Index: >19 kg/m2
• Age: between 18 and 70 year of age
• Caucasian

Exclusion Criteria:

• Receiving treatment with thermogenic, lipogenic, or contraceptive drugs
• Diabetes mellitus, chronic renal failure, hepatic diseases, or cancer diagnosis
• Bulimia diagnosis, prone to binge eating
• Undergoing treatment with anxiolytic or antidepressant drugs

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Temperature record	Measured using temperature sensor	Total of 1 week between Visit 1 and 2
Actigraphy record	Measured using Pendant Acceleration Data Logger	Total of 1 week between Visit 1 and 2

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Light record	Measured using Pendant Acceleration Data Logger	Total of 1 week between Visit 1 and 2
Sleep record	Measured using Pendant Acceleration Data Logger	Total of 1 week between Visit 1 and 2

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Sleep Duration	Sleep duration will be computed from self-reported	Total of 1 week between Visit 1 and 2
Total Energy Intake	Total energy intake in kcal/day will be computed from 7-day 24-hr dietary recalls	Total of 1 week between Visit 1 and 2
Dietary Composition	Macronutrient and micronutrient intake will be computed from 7-days of self-reported 24-hr dietary recalls	Total of 1 week between Visit 1 and 2
Dietary Intake Timing	Food timing will be self-reported and averaged across 7-days of 24-hr dietary recalls	Total of 1 week between Visit 1 and 2
Chronotype	Assessed using the Morningness-Eveningness Questionnaire	Total of 1 week between Visit 1 and 2

Collaborators and Investigators

• Sponsor: Universidad de Murcia

Publications and helpful links

General Publications

• Lopez-Minguez J, Ordonana JR, Sanchez-Romera JF, Madrid JA, Garaulet M. Circadian system heritability as assessed by wrist temperature: a twin study. Chronobiol Int. 2015 Feb;32(1):71-80. doi: 10.3109/07420528.2014.955186. Epub 2014 Sep 10.
• Lopez-Minguez J, Colodro-Conde L, Bandin C, Ordonana JR, Garaulet M, Madrid JA. Application of multiparametric procedures for assessing the heritability of circadian health. Chronobiol Int. 2016;33(2):234-44. doi: 10.3109/07420528.2015.1130051. Epub 2016 Jan 28.
• Lopez-Minguez J, Dashti HS, Madrid-Valero JJ, Madrid JA, Saxena R, Scheer FAJL, Ordonana JR, Garaulet M. Heritability of the timing of food intake. Clin Nutr. 2019 Apr;38(2):767-773. doi: 10.1016/j.clnu.2018.03.002. Epub 2018 Mar 12.

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2012
• Primary Completion (Actual): March 1, 2013
• Study Completion (Actual): February 1, 2017

Study Registration Dates

• First Submitted: February 13, 2017
• First Submitted That Met QC Criteria: February 20, 2017
• First Posted (Actual): February 23, 2017

Study Record Updates

• Last Update Posted (Actual): March 27, 2017
• Last Update Submitted That Met QC Criteria: March 23, 2017
• Last Verified: March 1, 2017

More Information

Terms related to this study

• Keywords: Circadian rhythms; Chronobiology; Twins; Heritability
• Other Study ID Numbers: 2017ES00002

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No