- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03078504
Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy
March 27, 2020 updated by: Zafar Jamkhana, MD, St. Louis University
Purpose of this study is to evaluate the short-term hemodynamic effects of changes in blood flow rates in critically ill patients receiving continuous renal replacement therapy.
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
6
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Missouri
-
Saint Louis, Missouri, United States, 63110
- Saint Louis University
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 89 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Age 18-89
- Acute renal failure or end-stage renal disease necessitating CRRT
- Admitted to the MICU service
- If on vasopressor/inotropic agent, norepinephrine as only intravenous pressor
- If on vasopressor/inotropic agent, at stable pressor dose for at least four hours
- If on IV fluids, stable dose of crystalloids <= 100cc/hour and is not receiving colloids for 4 hours or more prior to initiation of CRRT
- Mean arterial pressure (MAP) >= 65
- Arterial catheter present for continuous blood pressure monitoring
- CRRT duration of 48 hours or less using NxStage System One dialysis system
- successfully tolerated CRRT for at least 4 hours without clotting or hemodynamic instability
- no other procedures, blood products transfusion, or additional medication administration are anticipated during the study period
Exclusion Criteria:
- listed for organ transplant
- atrial fibrillation, other irregular heart rhythm, unstable arrhythmia
- need for more than one intravenous vasopressor agent
- intravenous vasopressor/inotropic agent other than norepinephrine (ie dobutamine, dopamine, vasopressin, epinephrine)
- therapeutic anticoagulation being administered
- known acute myocardial infarction as defined by elevated troponin along with a documented clinical diagnosis during current hospitalization
- known acute stroke, intracerebral hemorrhage, intracranial mass effect, or elevated intracranial pressure within the last 30 days.
- dialysis catheter malfunction and unable to maintain target blood flow rate
- fluid removal (ultrafiltration) rate > 100mL/hour
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Experimental arm
The patients will have the blood flow rate adjusted on CRRT gradually increased to assess the effect on hemodynamics
|
Participants who have been prescribed continuous renal replacement therapy will have hemodynamic parameters measured at various blood flow rates
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Blood Pressure Change
Time Frame: 10 minutes
|
Change in mean arterial pressure from period 1 to period 2
|
10 minutes
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Zafar Jamkhana, MD, Associate Professor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
February 17, 2017
Primary Completion (Actual)
June 6, 2018
Study Completion (Actual)
June 30, 2018
Study Registration Dates
First Submitted
March 8, 2017
First Submitted That Met QC Criteria
March 8, 2017
First Posted (Actual)
March 13, 2017
Study Record Updates
Last Update Posted (Actual)
March 30, 2020
Last Update Submitted That Met QC Criteria
March 27, 2020
Last Verified
March 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 26817
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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