Impulsivity and Time Perception

Link Between Impulsivity and Time Anticipation

Cannabis smokers having begun prematurely their consumption (before 16 years) present a persistent impulsivity much later after have stopped their consumptions. The literature highlights that the impulsivity promotes the passage towards a compulsive consumption, and the loss of control. To explain this phenomenon, some authors hypothesized that impulsivity would lead the subjects to overestimate the duration of events and to choose immediate rewards than preferred but delayed rewards. This hypothesis questions the role of the temporal anticipation in the impulsive choices. In a first hypothesis, the temporal impulsivity could be an endogenous deficit bound to the reward, and would be responsible for disorders of the temporal anticipation. In this case, the disorders should be observed especially when the subject anticipates a reward. Alternately, a disorder of the temporal anticipation could provoke impulsivity, and in this case, would be present with or without reward. To separate these hypotheses, we propose to test the capacities of temporal anticipation of non-smokers and early smokers of cannabis by means of a behavioral task " Hazard function task ", which allow to measure the capacity of a subject to anticipate the apparition of an event on the basis of a temporal cue. The neuronal correlates will be measured by a recording EEG of the wave ' CNV ' (fix a quota for denial of variation) which reflects the temporal accumulation and the processes of anticipation.

Study Overview

• Status: Completed
• Conditions: Cannabis Use

• Study Type: Observational
• Enrollment (Actual): 38

Contacts and Locations

• Study Contact: Name: Laurence LALANNE-TONGIO, MD; Phone Number: +33 3.88.11.51.35; Email: laurence.lalanne@chru-strasbourg.fr
• Study Contact Backup: Name: Anne GIERSCH, MD; Phone Number: +33 3.88.11.64.71; Email: giersch@unistra.fr

Study Locations

• France
  • Alsace
    • Strasbourg, Alsace, France, 67091
      • Les Hôpitaux Universitaires de Strasbourg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 50 years (Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Cannabis use Versus Non-smokers

Description

Inclusion Criteria:

• Healthy volunteers Man or woman of age between 18 and 50 years-old
• Absence of consumption of cannabis and tobacco for 1 year and absence of substance use disorder in history
• Matching in age and sex to the group consumers of cannabis
• Early consumers of cannabis (at the beginning of the consumptions before 16 years)
• Man or woman of age between 18 and 50 years old
• Statement of more than three consumptions a day of cannabis for at least one year and consumption of cannabis having begun before the age of 16 years.
• Urinary analysis is positive for the presence of cannabis
• Positive auto-questionnaire CAST: 2 positive answers to CAST questionnaire
• Hospitalized or not

Exclusion Criteria:

• Presence or history of a severe and invalidating somatic pathology (neurological, cardiovascular, lung, metabolic, renal, hepatic, gastro-intestinal)

  • History of cranial trauma with loss of consciousness.
  • substance use disorder except the substance tested in the protocol (cannabis).
  • Invalidating sensory disorders in particular visual: glaucoma, any retinal pathology. Visual acuteness 0.8
  • History of general anesthesia in the previous 3 months the study
  • Any evolutionary neurological or psychiatric pathology
  • Subject under guardianship
  • pregnancy
  • Feeding

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
P; for cannabis
C; for the control group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Measure the capacities of the subjects to anticipate the apparition of the target	on the basis of a temporal cue presented before the target, and give the response as quickly as possible after the presentation of a rewarding versus not rewarding target.	8 days after inclusion in the study

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France
• Investigators: Principal Investigator: Laurence LALANNE-TONGIO, MD, Hôpitaux Universitaires de Strasbourg

Study record dates

Study Major Dates

• Study Start (Actual): May 5, 2017
• Primary Completion (Actual): March 12, 2020
• Study Completion (Actual): March 12, 2020

Study Registration Dates

• First Submitted: May 19, 2017
• First Submitted That Met QC Criteria: May 19, 2017
• First Posted (Actual): May 22, 2017

Study Record Updates

• Last Update Posted (Actual): August 29, 2023
• Last Update Submitted That Met QC Criteria: August 24, 2023
• Last Verified: May 1, 2017

More Information

Terms related to this study

• Keywords: Addiction; Time perception; Early onset of cannabis use
• Additional Relevant MeSH Terms: Impulsive Behavior
• Other Study ID Numbers: 6526

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No