- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03164941
Effect of SLT Location on Treatment Outcomes (SLOS)
May 22, 2017 updated by: Enitan Sogbesan, St. Joseph's Healthcare Hamilton
Effect of 180 Degree Selective Laser Trabeculoplasty Location on Treatment Outcomes
Selective Laser Trabeculoplasty (SLT) is a glaucoma treatment that has been shown to effectively lower intraocular pressure by increasing aqueous outflow through macrophage recruitment.
There is evidence of increased drainage in the nasal quadrants of the eye.
This study aims to compare whether there is a difference in the reduction of eye pressure when SLT is performed nasally and temporally.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
This study aims to evaluate if there is a difference between 180 degree nasal and temporal selective laser trabeculoplasty (SLT) in treatment outcomes.
It is known that there is increased aqueous collectors and veins and thus aqueous drainage in the nasal quadrants of the eye.
If SLT works by the hypothesized biologic mechanism in which macrophages remodel the aqueous drainage system to increase outflow, performing SLT in an area concentrated with aqueous veins may increase outflow more.
As a result, we hypothesize that nasal 180 degree SLT may have better outcomes compared to the temporal counterpart.
The results of this study may help inform decisions when performing 180 degree SLT and provide insight to SLT's mechanism of action.
The primary objective of this study is to determine if there is a difference in treatment efficacy between nasal and temporal 180 degree SLT by measuring differences in baseline and post-operative intraocular pressures.
We hypothesize that nasal SLT will have superior outcomes compared to temporal SLT due to increased number of aqueous veins.
Study Type
Observational
Enrollment (Anticipated)
84
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Ontario
-
Hamilton, Ontario, Canada
- Recruiting
- St Joseph's Healthcare Hamilton - King Campus
-
Contact:
- Sharan Bains, MD
- Phone Number: 38504 905-522-1155
- Email: bainss@mcmaster.ca
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
The patients will be recruited from the glaucoma practice at St. Joseph's Healthcare Hamilton.
A baseline clinical eye examination will be completed to include or exclude the participant from the study according to the criteria below.
The baseline exam will include a comprehensive questionnaire of the participant's past ocular history, relevant systemic diseases, glaucoma risk factors, and surgical history.
Description
Inclusion Criteria:
- Diagnosis of open angle glaucoma, ocular hypertension, pigmentary dispersion syndrome and pseudoexfoliation syndrome
- Participant must be over 18 years of age
- IOP > 16mmHg on at least two consecutive occasions separated by one month
- Two sighted eyes with visual acuity of 20/200 or better
- Informed consent from patient
Exclusion Criteria:
- Diagnosis of secondary OAG (aside from pigmentary and pseudoexfoliation glaucoma) or narrow angle glaucoma
- Previous incisional glaucoma surgery
- Incisional glaucoma surgery scheduled within 1 year of intervention
- Corneal disease affecting visualization of anterior chamber of the eye
- Treatment or plan to treat with topical or systemic steroids
- Previous selective laser trabeculoplasty treatment
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Nasal SLT
This cohort will have 180 degree SLT completed on the nasal quadrants of the trabecular meshwork.
|
Laser treatment for glaucoma.
|
Temporal SLT
This cohort will have 180 degree SLT completed on the temporal quadrants of the trabecular meshwork.
|
Laser treatment for glaucoma.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Intraocular Pressure
Time Frame: 1 year
|
The primary outcome in this study is the change in intraocular pressure from baseline to the 1 year follow-up visit (continuous variable).
The percentage decrease in IOP from baseline will also be calculated and compared between the two groups.
|
1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
July 1, 2017
Primary Completion (Anticipated)
December 1, 2019
Study Completion (Anticipated)
December 1, 2020
Study Registration Dates
First Submitted
May 22, 2017
First Submitted That Met QC Criteria
May 22, 2017
First Posted (Actual)
May 24, 2017
Study Record Updates
Last Update Posted (Actual)
May 24, 2017
Last Update Submitted That Met QC Criteria
May 22, 2017
Last Verified
May 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 0000000000
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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