Blood Flow Index as an Indicator of Successful Peripheral Nerve Block

Blood Flow Index as an Indicator of Successful Peripheral Nerve Block : A Prospective Observational Study Using Laser Speckle Contrast Imaging.

Laser speckle contrast imaging (LSCI) allows real-time, non-invasive, quantitative measurements of regional blood flow. The aim of this prospective observational study was to evaluate the blood flow changes by LSCI after peripheral nerve block and determine whether this novel optical technique can be used as a reliable indicator of successful blocks.

Study Overview

• Status: Completed
• Conditions: Laser

Detailed Description

Methods: One hundred adult patients scheduled for elective upper or lower limb surgery with peripheral nerve block will receive LSCI measurements and pinprick sensory tests before the block and at 5-min intervals till 30 min after the block. The sensitivity, specificity of LSCI as a diagnostic method will be determined by receiver operator characteristic analysis.

Clinical Implications: LSCI with quantitative data could be used as an indicator of successful blocks.

• Study Type: Observational
• Enrollment (Actual): 110

Contacts and Locations

Study Locations

• China
  • Hubei
    • Wuhan, Hubei, China
      • Tongji Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

One hundred adult patients scheduled for elective upper or lower limb surgery with peripheral nerve block

Description

Inclusion Criteria:

• informed consent
• American Society of Anesthesiologists physical statusⅠ-Ⅱ
• Undergo elective upper or lower limb surgery with peripheral nerve block

Exclusion Criteria:

• refusal to participate in the study
• peripheral vascular disease
• digit injury or deficiency
• colored or infected fingernails/toenails
• BMI>35
• those who had taken vasodilatory drugs before surgery
• preoperative analgesic medications
• Any contraindications to peripheral nerve block such as coagulation abnormalities, allergy to local anaesthetics, peripheral neuropathy.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Peripheral nerve block group; patients scheduled for elective upper or lower limb surgery with peripheral nerve block will receive LSCI measurements and pinprick sensory tests at 5 min before the block and at 5-min intervals till 30 min after the block.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
diagnostic power of LSCI and pinprick sensory tests for predicting successful and failed blocks	sensitivity and specificity	at 5-min intervals till 30 min after regional block

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
blood flow index	perfusion unit(PU)	5 min before regional block and at 5-min intervals till 30 min after regional block

Collaborators and Investigators

• Sponsor: Huazhong University of Science and Technology

Publications and helpful links

General Publications

• Wu X, Li J, Joypaul K, Bao WW, Wang D, Huang YJ, Li PC, Mei W. Blood flow index as an indicator of successful sciatic nerve block: a prospective observational study using laser speckle contrast imaging. Br J Anaesth. 2018 Oct;121(4):859-866. doi: 10.1016/j.bja.2018.05.065. Epub 2018 Jul 4.

Study record dates

Study Major Dates

• Study Start (Actual): May 27, 2017
• Primary Completion (Actual): September 4, 2017
• Study Completion (Actual): September 4, 2017

Study Registration Dates

• First Submitted: May 24, 2017
• First Submitted That Met QC Criteria: May 25, 2017
• First Posted (Actual): May 30, 2017

Study Record Updates

• Last Update Posted (Actual): September 6, 2017
• Last Update Submitted That Met QC Criteria: September 4, 2017
• Last Verified: September 1, 2017

More Information

Terms related to this study

• Keywords: Peripheral nerve block; laser speckle contrast imaging; blood flow index
• Other Study ID Numbers: TJMZK20170325

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No
• IPD Plan Description: For patient's privacy

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No