- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03322826
Systematic Sampling of Lymph Nodes vs. Lymphadenectomy According to Intraoperative Frozen Pathology for Pulmonary Invasive Adenocarcinoma With Ground-glass Opacity
A Prospective and Multi-center RCT Study of Lymphadenectomy Based on Intraoperative Frozen Pathology for Pulmonary Invasive Adenocarcinoma Presenting With Ground Glass Opacity
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
On HRCT screening, early lung adenocarcinoma often contains a nonsolid component called ground-glass opacity (GGO). In 2011, pulmonary adenocarcinomas were classified into atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive carcinoma (MIA) and more extensively invasive adenocarcinoma (IAC) [1]. Early adenocarcinomas with GGO-dominant always mean low-grade malignancy and have an extremely favorable prognosis [2-5]. Previous studies have shown that patients with AAH, AIS and MIA have excellent survival rates (5-year survival rate is approximate 95%) after resection, and only 0.83% - 2.91% patients have lymph node metastasis [6-9]. At present, lymphadenectomy is always undergone in patients with pulmonary adenocarcinoma with ground-glass opacity. However, for MIA patients (especially in T1a-b stage), the appropriate use of lymphadenectomy continues to be debated.
Nowadays, intraoperative frozen pathology is widely used during operation. However, whether sampling of lymph nodes or lymphadenectomy should be performed for GGO lesions according to intraoperative pathological diagnosis is unclear. The aim of this prospective study is to evaluate whether there are any trends regarding the impact of subtypes of invasive adenocarcinoma according to intraoperative frozen pathology in sampling of lymph nodes vs. lymphadenectomy.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Chang Chen, M.D. Ph.D.
- Phone Number: 13816869003
- Email: chenthoracic@163.com
Study Locations
-
-
Shanghai
-
Shanghai, Shanghai, China, 200000
- Recruiting
- Shanghai Pulmonary Hospital
-
Contact:
- Chang Chen, MD,PhD
- Phone Number: 13816869003
- Email: chenthoracic@163.com
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- A peripheral nodular lesion;
- The maximum diameters of whole GGO lesions and solid components on lung windows were no more than 3 cm (T1 stage);
- VATS lobectomy
- 25%≦Consolidation/Tumor ratio ≦50%
- ECOG performance status 0-2;
- Without distant metastasis;
- Intraoperative frozen pathology confirmed invasive or minimally invasive adenocarcinoma.
- No operation contraindication
- Cardiovascular: Cardiac function normal
- Renal: Creatinine clearance greater than 60 ml/min
- The expected survival after surgery ≥ 6 months
- Must be able to sign written informed consent form
Exclusion Criteria:
- Age less than 18 years old
- Known hereditary bleeding disorder with history of post-operative hemorrhage
- Patients maintained on chronic anticoagulation (eg Coumadin therapy)
- Known hematogenous disorder
- Known primary or secondary malignancy
- Pregnant or breast-feeding women;
- Clinically significant heart disease;
- Patients who are unwilling or unable to comply with study procedures;
- Receiving immunosuppressive therapy;
- HIV/AIDS.
- Multiple lesions in lung
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Lymphadenectomy
systematically Lymphadenectomy of the lymph-node stations ATS 2, 4, 7, 8, 9,10,11 on the right side and ATS 5, 6, 7, 8, 9,10,11 on the left side
|
Routine lymph nodes dissection in lung cancer
|
Experimental: systematic sampling of the lymph nodes
systematic sampling of the lymph-node stations ATS 2, 4, 7, 8, 9,10,11 on the right side and ATS 5, 6, 7, 8, 9,10,11 on the left side
|
Systematic Sampling of lymph nodes
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
recurrence-free survival
Time Frame: five years after surgery
|
recurrence-free survival status of patients after surgery
|
five years after surgery
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overall Survival
Time Frame: five years after surgery
|
survival status of patients after surgery
|
five years after surgery
|
Morbidity rate
Time Frame: up to 30 days after surgery
|
the rates of complications related to treatment during perioperative period
|
up to 30 days after surgery
|
Mortality rate
Time Frame: up to 30 days after surgery
|
the rates of death related to treatment during perioperative period
|
up to 30 days after surgery
|
Collaborators and Investigators
Publications and helpful links
General Publications
- Tsutani Y, Miyata Y, Nakayama H, Okumura S, Adachi S, Yoshimura M, Okada M. Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma: wedge resection or segmentectomy. Chest. 2014 Jan;145(1):66-71. doi: 10.1378/chest.13-1094.
- Ye B, Cheng M, Li W, Ge XX, Geng JF, Feng J, Yang Y, Hu DZ. Predictive factors for lymph node metastasis in clinical stage IA lung adenocarcinoma. Ann Thorac Surg. 2014 Jul;98(1):217-23. doi: 10.1016/j.athoracsur.2014.03.005. Epub 2014 May 17.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SHDC12015116
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Lymph Node Excision
-
Tianjin Medical University Cancer Institute and...RecruitingLung Neoplasms | Lymph Node ExcisionChina
-
Qilu Hospital of Shandong UniversityNot yet recruitingChemoradiotherapy | Colorectal Neoplasms Malignant | Lymph Node ExcisionChina
-
Cancer Institute and Hospital, Chinese Academy...Shanxi Province Cancer Hospital; Guangdong Provincial Hospital of Traditional... and other collaboratorsNot yet recruitingColorectal Neoplasms | Fluorescence | Lymph Node ExcisionChina
-
Ethicon Endo-SurgeryCompletedExcision of KidneyUnited States
-
University of PennsylvaniaFood and Drug Administration (FDA); EUSA Pharma, Inc.; Castleman Disease Collaborative...RecruitingCastleman Disease | Castleman's Disease | Giant Lymph Node Hyperplasia | Angiofollicular Lymph Hyperplasia | Angiofollicular Lymph Node Hyperplasia | Angiofollicular Lymphoid Hyperplasia | GLNH | Hyperplasia, Giant Lymph Node | Lymph Node Hyperplasia, GiantUnited States
-
Shanghai Chest HospitalUnknown
-
Mansoura UniversityGustave Roussy, Cancer Campus, Grand Paris; West oncologic center, Nantes,...CompletedTotal Mesorectal Excision | LaparoscopicEgypt
-
Massachusetts General HospitalBrigham and Women's Hospital; Society of University SurgeonsRecruiting
-
Federation of Breast Diseases SocietiesUnknown
-
TakedaCompleted
Clinical Trials on lymphadenectomy
-
Hospital Universitari Vall d'Hebron Research InstituteFundación Mutua MadrileñaCompletedOvarian Neoplasms | Endometrial NeoplasmsSpain
-
Hospital Universitari Vall d'Hebron Research InstituteEuropean Regional Development FundCompletedOvarian Neoplasms | Endometrial NeoplasmsSpain
-
University of AlexandriaCompleted
-
West China HospitalRoyal Liverpool University HospitalUnknownCarcinoma, Pancreatic DuctalChina
-
Fujian Medical UniversityEnrolling by invitation
-
National Cancer Center, KoreaUnknownGastric CancerKorea, Republic of
-
Melanoma and Skin Cancer Trials LimitedMelanoma Institute Australia; Cancer Council New South WalesActive, not recruitingMetastatic Melanoma to the Groin Lymph NodesUnited Kingdom, Slovenia, Australia, Brazil, Netherlands, Italy
-
Assistance Publique Hopitaux De MarseilleCompleted
-
Zealand University HospitalSuspended
-
Ruijin HospitalShanghai Zhongshan Hospital; Xinhua Hospital, Shanghai Jiao Tong University...CompletedPancreatic Ductal AdenocarcinomaChina