- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03344380
Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population
January 10, 2019 updated by: Yonsei University
Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors.
Prevention of postoperative acute kidney injury is essential for postoperative care in liver transplantation recipients.
The aim of this study is to investigate the relationship between gene polymorphisms and the occurrence of acute kidney injury after liver transplantation by performing genome-wide association study (GWAS).
Study Overview
Status
Unknown
Study Type
Observational
Enrollment (Anticipated)
330
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Seoul, Korea, Republic of, 03722
- Recruiting
- Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
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Contact:
- Seung Ho Choi, MD
- Phone Number: +82-2-2228-2420
- Email: csho99@yuhs.ac
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
19 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Adult patients scheduled for liver transplantation
Description
Inclusion Criteria:
1) adult patients scheduled for liver transplantation
Exclusion Criteria:
- Patients on dialysis
- patients not able to read, or understand the consent form
- ethnicity, other than asian
- patients refusal
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
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Prospective cohort
Adult patients undergoing liver transplantation will be included and followed up during the first 72 hours post-liver transplantation in order to confirm the development of acute kidney injury.
The patients will be divided into two groups (AKI group vs. non-AKI group) according to the development of acute kidney injury.
The GWAS will be performed with the blood obtained from enrolled patients.
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Retrospective cohort
In previous study performed in adult patients undergoing liver transplantation (NCT02489474, 4-2015-0411), we enrolled patients and collected data regarding the development of acute kidney injury during the first 72 hours post-liver transplantation.
Among these patients enrolled in this previous study, only patients who agreed to additional use of the blood sample for research purposes will be included in the present study.
The GWAS will be performed with the blood obtained from enrolled patients.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Acute kidney injury after liver transplantation
Time Frame: Participants will be followed up during the first 72 hours post-liver transplantation in order to confirm the development of acute kidney injury.
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The development of acute kidney injury is defined by the following definition: 50% increase in SCr from the baseline (preoperative value) or a 0.3 mg/dl increase from baseline within 48 h without urine output.
The development of acute kidney injury after liver transplantation could correlate with gene polymorphisms, which have been known to be associated with postoperative acute kidney injury.
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Participants will be followed up during the first 72 hours post-liver transplantation in order to confirm the development of acute kidney injury.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
November 1, 2017
Primary Completion (Anticipated)
November 1, 2020
Study Completion (Anticipated)
December 1, 2020
Study Registration Dates
First Submitted
November 13, 2017
First Submitted That Met QC Criteria
November 13, 2017
First Posted (Actual)
November 17, 2017
Study Record Updates
Last Update Posted (Actual)
January 11, 2019
Last Update Submitted That Met QC Criteria
January 10, 2019
Last Verified
January 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 4-2017-0888
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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