The Utility of Platelet Rich Plasma in Hair Loss

Platelet rich plasma (PRP) is an autologous preparation of human plasma with high concentration of platelets. Platelets release numerous growth factors, which stimulate cell proliferation and differentiation.

The purpose of this research is to investigate the potential of PRP injection for treatment of hair loss. Clinical outcomes will be assessed by noninvasive techniques including dermoscopy, multiphoton microscopy, optical coherence tomography, optical Doppler tomography and multispectral imaging.

Study Overview

• Status: Completed
• Conditions: Androgenetic Alopecia
• Intervention / Treatment: Procedure: Platelet rich plasma

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Early Phase 1

Contacts and Locations

Study Locations

• United States
  • California
    • Irvine, California, United States, 92697
      • University of California, Irvine, Department of Dermatology, Dermatology Clinical Research Center, Hewitt Hall

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 93 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Over 18 years of age
• Ability to understand and carry out instructions
• Diagnosed with alopecia

Exclusion Criteria:

• Inability to understand and.or carry out instructions
• Pregnant women
• Use of any topical medication (such as minoxidil or any other solution for hair growth), oral medication (finasteride, dutasteride, or antiandrogens), laser therapy, or chemotherapy, within the preceding 4 weeks.
• Personal medical history of bleeding disorders
• Personal medical history of platelet dysfunction syndrome
• Anti-coagulation therapy or nonsteroidal anti-inflammatory drugs in the last 1 week.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Prospective treatment	Procedure: Platelet rich plasma; Blood drawn from each participant will be spun down to separate platelets. Platelets will be injected into that patient's scalp.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Hair density to measure the efficacy of treatment	6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hair count (number of hairs/0.65 cm2)		6 months
Terminal hair density		6 months
Anagen hair percentage		6 months
Telogen hair percentage		6 months
Anagen/telogen ratio		After 3 and 6 months
Changes in hair structure, diameter, and blood flow	As measured by optical coherence tomography	6 months

Collaborators and Investigators

• Sponsor: University of California, Irvine

Study record dates

Study Major Dates

• Study Start (Actual): November 28, 2017
• Primary Completion (Actual): February 20, 2019
• Study Completion (Actual): February 20, 2019

Study Registration Dates

• First Submitted: December 13, 2017
• First Submitted That Met QC Criteria: December 13, 2017
• First Posted (Actual): December 18, 2017

Study Record Updates

• Last Update Posted (Estimated): February 2, 2024
• Last Update Submitted That Met QC Criteria: February 1, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases; Pathological Conditions, Anatomical; Hypotrichosis; Hair Diseases; Alopecia
• Other Study ID Numbers: 20163239

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: Yes