Radio-frequency Identification (RFID) Osteoporosis Pilot Study

RFID Osteoporosis Pilot Study

This examines in-vivo microwave sensing to measure a radio- frequency signal propagating through the wrist and, based on this information, establish a correlation of measured parameters with the integral bone density. This radio- frequency device is designed to obtain an integral estimate of bone density (osteoporotic vs normal).

The measurements can be done in three ways. The first method (Method 1) utilizes Received Signal Strength (RSS) of an RFID tag array at 915 megahertz located on the top of the wrist. The transmitting antenna located on the bottom of the wrist is connected to an RFID reader. In that way, the signal travels twice across the wrist: from the reader to the tag and vice versa.

The second method (Method 2) is to use only one transmitting antenna, connect the transmitting antenna to a portable Network Analyzer and measure the reflection coefficient, S11, of the antenna itself. This method does not imply that the entire signal will travel back and forth through the wrist, although its significant portion will. This method is, however, broadband and allows us to measure antenna resonances, which are very sensitive to the wrist composition.

The third method (Method 3) is to use both transmitting and receiving antennas, connect the antennas to a portable KeySight Network Analyzer and measure the transmission coefficient, S21, of the antenna pair. This method implies that the entire signal will travel through the wrist once. This method is also broadband and allows us to measure decay of the radio-signal in the wrist over a band of frequencies.

The two last methods could be combined together.

Study Overview

• Status: Unknown
• Conditions: Bone Loss, Age Related; Age-Related Bone Loss

• Study Type: Observational
• Enrollment (Anticipated): 24

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 27 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

We are interested in a population comprised of female patients with and without osteoporosis.

Description

Inclusion Criteria:

In osteoporotic patients:

• 50-80 years of age
• Established diagnosis of osteoporosis, based on prior dual energy x-ray absorptiometry (DXA) scan with T-score <-2.0 at any site and/or history of fragility fracture

In healthy controls:

• 27-40 years of age
• Female

Exclusion Criteria:

In osteoporotic patients:

• Current or recent (within 2 years) use of osteoporosis medications including bisphosphonates, hormone replacement therapy, selective estrogen receptor modulators, teriparatide, denosumab, calcitonin, or strontium
• Pregnancy or breastfeeding within the past 2 years
• Any medical or psychiatric condition or situation that would compromise subject safety, informed consent/assent, or data quality

In healthy controls:

• History of significant cardiac, renal, pulmonary, hepatic, or malignant disease, or current alcohol or illicit drug abuse
• Current diagnoses known to effect bone metabolism, including cystic fibrosis, diabetes, osteoporosis, amenorrhea >3 months (in menstruating women who are not taking oral contraceptives or have an IUD), hyperthyroidism, hyperparathyroidism, Paget's disease, kidney stones, chronic inflammatory diseases, malabsorptive disorders, malnutrition or eating disorder, endocrine disorders (growth disorder, Cushing syndrome), prolonged immobility, and skeletal dysplasias
• History one or more pathologic fracture, or greater than four total lifetime non-digital, non-facial fractures
• Cumulative lifetime use of oral glucocorticoids for greater than 2 months
• Current or previous use of medications known to affect bone metabolism including hormone replacement therapy, anti-estrogens, bisphosphonates, calcitonin, lithium, suppressive doses of levothyroxine, or anticonvulsants.
• Pregnancy or breastfeeding within the past 2 years
• BMI less than 18.5 or greater than 30 kg/m2.
• Any medical or psychiatric condition or situation that would compromise subject safety, informed consent/assent, or data quality

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Osteoporotic; Femal, 50-80 years of age with established diagnosis of osteoporosis, based on prior DXA scan with T-score <-2.0 at any site and/or history of fragility fracture
Non-osteoporotic; Female, 27-40 years of age, no established history of osteoporosis

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Osteoporosis Screening through the use of a novel On-Body Passive Radio Frequency Identification (RFID) Array and corresponding test bed to include a receiving antenna.	A measurement will be performed to assess if a given patient is or is not at risk of osteoporosis. The measurement is based on the received signal strength or power received from the RFID tag.	Data from the testing will be available in near real-time and will be collated and reported on within 1 week of the assessment

Collaborators and Investigators

• Sponsor: Neva Electromagnetics, LLC
• Collaborators: Massachusetts General Hospital

Study record dates

Study Major Dates

• Study Start (Anticipated): January 31, 2018
• Primary Completion (Anticipated): September 1, 2018
• Study Completion (Anticipated): December 1, 2018

Study Registration Dates

• First Submitted: November 13, 2017
• First Submitted That Met QC Criteria: December 20, 2017
• First Posted (Actual): December 29, 2017

Study Record Updates

• Last Update Posted (Actual): January 26, 2018
• Last Update Submitted That Met QC Criteria: January 24, 2018
• Last Verified: January 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Metabolic Diseases; Musculoskeletal Diseases; Bone Diseases; Bone Diseases, Metabolic; Osteoporosis
• Other Study ID Numbers: 2017P001452

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No