Neural Mechanisms of Decision Making in Hoarding Disorder (LOSS)

July 15, 2025 updated by: Carolyn Rodriguez, Stanford University
The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

Hoarding disorder is a common and disabling disorder that represents a significant public health problem. This study aims to build on current research on decision making by examining these processes in hoarding disorder.

Study Type

Observational

Enrollment (Estimated)

25

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Stanford, California, United States, 94305
        • Stanford University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Individuals with Hoarding Disorder and Healthy Participants

Description

Identify inclusion criteria.

Inclusion criteria for participants diagnosed with HD:

  1. ages 18-70
  2. primary diagnosis of hoarding disorder
  3. sufficient severity of hoarding symptoms
  4. stable on psychotropic medications for 1 month prior to study enrollment
  5. capacity to provide informed consent
  6. ability to tolerate clinical study procedures

Inclusion criteria for healthy control participants:

  1. ages 18-70
  2. capacity to provide informed consent

Identify exclusion criteria.

Exclusion criteria for participants with HD:

  1. psychiatric or medical conditions that make participation unsafe
  2. pregnant or nursing females
  3. concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)
  4. presence of metallic device or dental braces

Exclusion criteria for healthy control participants:

  1. any current or lifetime psychiatric diagnosis
  2. current or past use of psychotropic medication
  3. pregnant or nursing females
  4. major medical or neurological problem
  5. presence of metallic device or dental braces

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Hoarding Disorder
Adults diagnosed with Hoarding Disorder
Device: MRI with fMRI frequency
Functional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow. Participants will do cognitive tasks during fMRI.
Healthy Controls
Adults without mental illness
Device: MRI with fMRI frequency
Functional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow. Participants will do cognitive tasks during fMRI.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
BOLD signal
Time Frame: up to 90 minutes
BOLD signal derived from fMRI
up to 90 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Stanford University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 8, 2018

Primary Completion (Estimated)

May 30, 2026

Study Completion (Estimated)

May 30, 2026

Study Registration Dates

First Submitted

March 27, 2018

First Submitted That Met QC Criteria

March 27, 2018

First Posted (Actual)

April 3, 2018

Study Record Updates

Last Update Posted (Actual)

July 16, 2025

Last Update Submitted That Met QC Criteria

July 15, 2025

Last Verified

July 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 42327

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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