- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03487224
Neural Mechanisms of Decision Making in Hoarding Disorder (LOSS)
April 15, 2024 updated by: Carolyn Rodriguez, Stanford University
The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.
Study Overview
Status
Active, not recruiting
Conditions
Intervention / Treatment
Detailed Description
Hoarding disorder is a common and disabling disorder that represents a significant public health problem.
This study aims to build on current research on decision making by examining these processes in hoarding disorder.
Study Type
Observational
Enrollment (Estimated)
25
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
California
-
Stanford, California, United States, 94305
- Stanford University
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 70 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Sampling Method
Probability Sample
Study Population
Individuals with Hoarding Disorder and Healthy Participants
Description
Identify inclusion criteria.
Inclusion criteria for participants diagnosed with HD:
- ages 18-70
- primary diagnosis of hoarding disorder
- sufficient severity of hoarding symptoms
- stable on psychotropic medications for 1 month prior to study enrollment
- capacity to provide informed consent
- ability to tolerate clinical study procedures
Inclusion criteria for healthy control participants:
- ages 18-70
- capacity to provide informed consent
Identify exclusion criteria.
Exclusion criteria for participants with HD:
- psychiatric or medical conditions that make participation unsafe
- pregnant or nursing females
- concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)
- presence of metallic device or dental braces
Exclusion criteria for healthy control participants:
- any current or lifetime psychiatric diagnosis
- current or past use of psychotropic medication
- pregnant or nursing females
- major medical or neurological problem
- presence of metallic device or dental braces
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Hoarding Disorder
Adults diagnosed with Hoarding Disorder
|
Functional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow.
Participants will do cognitive tasks during fMRI.
|
Healthy Controls
Adults without mental illness
|
Functional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow.
Participants will do cognitive tasks during fMRI.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
BOLD signal
Time Frame: up to 90 minutes
|
BOLD signal derived from fMRI
|
up to 90 minutes
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 8, 2018
Primary Completion (Estimated)
May 30, 2024
Study Completion (Estimated)
May 30, 2024
Study Registration Dates
First Submitted
March 27, 2018
First Submitted That Met QC Criteria
March 27, 2018
First Posted (Actual)
April 3, 2018
Study Record Updates
Last Update Posted (Actual)
April 17, 2024
Last Update Submitted That Met QC Criteria
April 15, 2024
Last Verified
April 1, 2024
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 42327
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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