- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03497208
Comparative Study of Surgical Treatment of Vitiligo
April 6, 2018 updated by: Hospital de Clinicas de Porto Alegre
Comparative Study of Surgical Treatment of Vitiligo: Microneedling Versus Microneedling With Suspension of Uncultured Epidermal Cells
A comparative study for the surgical treatment of vitiligo in which the same patient will receive in acromic and symmetric lesions of vitiligo dermabrasion with micro needling and on the other side dermabrasion with micro needling followed by the application of cell suspension (melanocytes and uncultured keratinocytes).
These cells will be removed from the own patient through the skin of the scalp.
After the surgical procedure, patients will be submitted to UVB-NB phototherapy sessions (twice a week) and evaluated for repigmentation of vitiligo lesions at 14 and 24 weeks of treatment.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
Background: Vitiligo is characterized by a depigmentation acquired with partial or total loss of melanocytes from the epidermis, causing great psychosocial impact.
Several therapeutic modalities have been proposed for its treatment and surgical treatments have been shown to be promising, especially in recalcitrant cases.
The technique of epidermal rasping grafting, a variant of the punch micrografts technique, shows high repigmentation rates and does not require high cost technology.
Objective: The objective of this project is to perform a comparative study for the surgical treatment of vitiligo, in which the same patient (N = 10) will receive, in symmetrical acrylic areas, only dermabrasion with a micro needling of 0.25 mm or dermabrasion using micro needling followed of the cell suspension application (melanocytes and uncultured keratinocytes).
Methodology: In the donor area (scalp) the healthy tissue will be removed.
This tissue will be placed in a sterile container with physiological saline and fragmented with delicate scissors for about 20 minutes until homogeneous consistency of the material is obtained.
After the enzymatic digestion of epidermal cells of the dermis, it will isolate melanocytes and keratinocytes that will be placed in the recipient area.
After 15 days of the surgical procedure, patients will start the phototherapy UVB-NB sessions (twice a week).
The patients will be evaluated about the pain during the procedure, the improvement of injuries of vitiligo and the vitiligo-specific quality-of-life instrument (VitiQoL Vitqol Index) will be applied after and before the treatment.
Conclusion: The technique of grafting by epidermal scrap shows high rates of repigmentation and does not require high cost technology, which motivated us, in this study, corroborating the literature and helping to disseminate this technique.
Study Type
Interventional
Enrollment (Anticipated)
10
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: ROBERTA TOWNSEND, MD
- Phone Number: +5551998280048
- Email: TOWNSEND@TERRA.COM.BR
Study Locations
-
-
RS
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Porto Alegre, RS, Brazil, 90035903
- Recruiting
- HCPA
-
Contact:
- ROBERTA TOWNSEND, MD
- Phone Number: +5551998280048
- Email: TOWNSEND@TERRA.COM.BR
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
14 years to 70 years (Child, Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Older than 14 years old
- Patients in treatment in the Dermatology Service HCPA
- Patients able to do UVB - NB phototherapy
- Patients with stable vitiligo lesions more than 1 year
Exclusion Criteria:
- Under 14 years old
- Patients unable to do phototherapy UVB-NB
- Unstable vitiligo lesions less than 1 year
- Patients with immunodeficiency (diabetes, infection, use of immunosuppressive drugs)
- Pregnancy and lactating
- Phototherapy session less than 2 months
- Patients with some kind of allergy about the drugs that will be used (like lidocaine anesthetic cream or chlorhexidine antiseptic)
- Patients using photosensitizing drugs
- Patients with keloids history, Hypertrophic scar or post inflammatory Hyperpigmentation.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Microneedling+cell susp+phototherapy
Experiment is about the use of abrasion technic with dermaroller, equipped with a 0,25mm needle, applied on a vitiligo lesion.
After that, a transplant with non cultured cell suspension (melanocytes and keratinocytes) will be applied to pacient 's skin scalp.
|
The technique is about applying a dermaroller equipped with 0.25 mm needles over the vitiligo area.
The technique involves preparation of a cell suspension (keratinocyte/melanocyte) prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermarollerequipped with 0.25 mm needles.
The patient will receive phototherapy UVB-NB in the lesions of vitiligo after 15 days of the surgical procedure.
|
Active Comparator: Microneedling and phototherapy
Technique involves only the abrasion with dermaroller equipped with 0,25mm on the lesion of vitiligo.
|
The technique involves preparation of a cell suspension (keratinocyte/melanocyte) prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermarollerequipped with 0.25 mm needles.
The patient will receive phototherapy UVB-NB in the lesions of vitiligo after 15 days of the surgical procedure.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Evaluate the repigmentation of vitiligo lesion
Time Frame: The measure will be made in 24 weeks after the procedure
|
Through a transparent millimeter paper the vitiligo area will be measure
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The measure will be made in 24 weeks after the procedure
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Vitiligo-specific quality-of-life instrument (VitiQoL).
Time Frame: 6 months
|
A negative impact on vitiligo patients in terms of quality of life has been suggested.
We propose evaluate the quality life in this patients after and before the treatment using the the vitiligo-specific quality-of-life instrument (VitiQoL).
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6 months
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Pain index
Time Frame: 6 months
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Evaluate in scale of 1 to 10 the pain of the procedure described by the patient
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6 months
|
Index of satisfaction
Time Frame: 6 months
|
Evaluate the satisfaction of the patient with this treatment using a scale of 1 to 5
|
6 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Study Director: Tania Cestari, Dr, Federal University of Health Science of Porto Alegre
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
March 13, 2018
Primary Completion (Anticipated)
October 13, 2018
Study Completion (Anticipated)
December 13, 2019
Study Registration Dates
First Submitted
April 6, 2018
First Submitted That Met QC Criteria
April 6, 2018
First Posted (Actual)
April 13, 2018
Study Record Updates
Last Update Posted (Actual)
April 13, 2018
Last Update Submitted That Met QC Criteria
April 6, 2018
Last Verified
April 1, 2018
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 170596
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Undecided
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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