- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03503123
Deventilation Dyspnea in COPD Patients Using NIV
Deventilation Dyspnea in Patients With Chronic Obstructive Pulmonary Disease After Switching Off From Non-invasive Ventilation
Study Overview
Status
Conditions
Detailed Description
Rationale: Non-invasive ventilation (NIV) has shown to be an effective therapy for patients with Chronic Obstructive Pulmonary Disease (COPD) with Chronic Hypercapnic Respiratory Failure (CHRF). However, these COPD patients often report severe dyspnoea after switching off from NIV therapy, which leads to discomfort and distress. Currently, it is not known what causes this deventilation dyspnoea and therefore a possible treatment to prevent deventilation dyspnoea is not available.
Objective: 1) To investigate what mechanisms underlie the phenomenon of deventilation dyspnoea in COPD patients. 2) To investigate how the change in electrical impedance, measured with electrical impedance tomography (EIT), is related to the change in inspiratory capacity (IC) before and after sleep.
Study design: This study is an observational cohort study analysing changes occurring due to NIV which could explain the existence of deventilation dyspnoea in certain COPD patients using NIV. Ten patients with and ten patients without deventilation dyspnoea will visit the hospital for an afternoon sleep, during and after which several non-invasive measurements are performed to analyse the changes occurring during and after switching off NIV. In order to investigate the deventilation problem, we will measure:
- the degree of hyperinflation due to NIV: this will be assessed by measuring the change in end-expiratory lung volume (EELV) with EIT before, during and after NIV, and the change in IC before and after sleeping with NIV.
- the reduction of respiratory muscle activity due to NIV: this will be assessed by the change in electromyography of the frontal diaphragm before, during and after NIV.
- the effectiveness of NIV in reducing CO2 level: this will be assessed with transcutaneous CO2 measurements (PtcCO2) before, during and after NIV.
- the degree of deventilation dyspnoea before and after the afternoon sleep: this will be assessed with a 10-point Borg Scale.
Study population: Twenty severe COPD patients (age>18yr) using chronic NIV will be included in the study: 10 patients with severe symptoms of deventilation dyspnoea (Borg Dyspnoea Scale ≥ 5) and 10 patients without symptoms of deventilation dyspnoea, matched with regard to the degree of static lung hyperinflation and NIV settings.
Main study parameters/endpoints: Knowledge about the changes occurring during NIV in patients with COPD with deventilation dyspnoea. The percent change in EELV, IC, respiratory muscle activity and PtcCO2 will be calculated for both groups and correlated with the degree of deventilation dyspnoea.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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Groningen, Netherlands
- Recruiting
- Department of Pulmonary diseases
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Contact:
- Marieke Duiverman, MD PhD
- Phone Number: 0031-50-3613200
- Email: m.l.duiverman@umcg.nl
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- COPD with a NIV indication using chronic NIV
- Age > 18 years
- With or without deventilation dyspnea when switching off from NIV (depending on group/cohort)
- Written informed consent is obtained
Exclusion Criteria:
- COPD exacerbation within 2 weeks preceding the study
- Modification of ventilation within 2 weeks preceding the study
- Having a poor compliance with NIV (usage of <4 h/day)
- Having other disorders leading to respiratory failure (such as morbid obesity, kyphoscoliosis, neuromuscular diseases, tuberculosis)
- Not being able to sleep 1.5 hour in the afternoon
- Having spinal injury, BMI>50, damaged or inflamed skin around the thorax or a cardiac pacemaker or other implanted devices
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Cross-Sectional
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
COPD patients with deventilation dyspnoea
Ten severe COPD patients (age>18yr) using chronic NIV with severe symptoms of deventilation dyspnoea (Borg Dyspnoea Scale ≥ 5)
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Both groups get the same exposures: with measure physiology in both groups by using non-invasive measurement techniques.
The techniques we use are Electrical Impedance Tomography to determine degree of hyperinflation.
We use Electromyography to analyse respiratory drive.
We measure transcutaneous carbon dioxide to assess the effects of non-invasive ventilation.
Thereby, we will perform lung function tests.
|
COPD patients without deventilation dyspnoea
Ten severe COPD patients (age>18yr) using chronic NIV without symptoms of deventilation dyspnoea, matched with the first cohort/group with regard to the degree of static lung hyperinflation and NIV settings.
|
Both groups get the same exposures: with measure physiology in both groups by using non-invasive measurement techniques.
The techniques we use are Electrical Impedance Tomography to determine degree of hyperinflation.
We use Electromyography to analyse respiratory drive.
We measure transcutaneous carbon dioxide to assess the effects of non-invasive ventilation.
Thereby, we will perform lung function tests.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
End-expiratory lung volume
Time Frame: Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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The change in end-expiratory lung volume due to NIV-usage
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Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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Inspiratory capacity
Time Frame: Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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The change in inspiratory capacity due to NIV-usage
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Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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Respiratory muscle activity
Time Frame: Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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The change in respiratory muscle activity due to NIV-usage
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Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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Transcutaneous carbon dioxide
Time Frame: Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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The change in transcutaneous carbon dioxide due to NIV-usage
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Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Correlation of inspiratory capacity with end-expiratory lung volume
Time Frame: Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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To validate Electrical Impedance Tomography measurements to determine end-expiratory lung volume, we will compare these outcomes with the golden standard inspiratory capacity.
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Through study completion, which is one day of NIV use. Compare the primary outcome before and after the afternoon sleep.
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Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 201800263
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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