- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03874754
Tailored Home-Based Exercise Program for Multiple Chronic Conditions (iHBE)
August 24, 2022 updated by: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Assessment of a Tailored Home-Based Exercise Program on Symptoms, Well-Being, and Resilience Among Cancer Survivors With Multiple Chronic Conditions
A home-based, tailored, technology-enhanced home-based exercise program (iHBE) using a combination of the integrated mobile technologies (wearable device and phone application) and tailored home-based exercise will be pilot tested.
Participants will choose one of the four home-based exercise options [National Institute of Aging (NIA) Go4Life (an exercise and physical activity campaign from the NIA), Iyengar-style yoga, walking, and modified Otago exercise] based on participants' preference and goals.
The integrated mobile technologies system will allow the investigators to extract heart rate data directly from the wearable device to the research server.
This data will be used to provide appropriate and personalized feedback on physical performance.
The survey and notification to the participants on the smartphone.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The benefits of physical activity on managing chronic illnesses and multiple symptoms are well established.
However, increasing the physical activity of persons living with Multiple Chronic Conditions (MCC), especially low -income cancer survivors with MCC, is challenging.
Home-based exercise improves physical activity and symptoms among persons with the single chronic disease.
One major challenge of the home-based exercise is the motivation and adherence.
The mobile technologies (e.g., wearable device and smartphone application) have been used to improve motivation and monitor a person physical activity.
Guided by the society to cells framework and previous preliminary findings, the investigators developed a technology-enhanced home-based exercise program using a combination of the integrated mobile technologies (wearable device and phone application) and tailored home-based exercise.
Participants will choose one of the four home-based exercise options [National Institute of Aging (NIA) Go4Life, Iyengar-style yoga, walking, and modified Otago exercise] based on participants' preference and goals.
The integrated mobile technologies system will allow the investigators to extract heart rate data directly from the wearable device to the research server.
This data will be used to provide appropriate and personalized feedback on physical performance and trigger algorithms to send the survey and notification to the participants in real time.
This pilot project will examine the feasibility of this technology-enhanced home exercise tailored to participants' goals and preferences.
The intervention will leverage the cancer survivorship phase (post-treatment) to motivate self-care by combining tailored existing evidence-based physical activity programs and mobile technology for participants to engage in the resilience-enhancing physical activity.
Identification of BDNF's role as one of the exercise outcomes provide a novel target for an intervention and increase the investigators' understanding of the underlying mechanism of symptoms and resilience.
This study aims to examine the feasibility and acceptability of the iHBE program among low-income cancer survivors living with co-morbid conditions.
Eight participants who have completed treatment for a solid tumor cancer with at least one comorbidity (e.g., diabetes and/or hypertension) will be assigned to an open-label trial of the idea.
The investigators will gather feedback on goal setting, problem-solving strategies, exercise choices, and tracking mechanisms, program feasibility, and acceptability and modify the intervention as needed.
Study Type
Interventional
Enrollment (Actual)
34
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Maryland
-
Baltimore, Maryland, United States, 21205
- The Sidney Kimmel Comprehensive Cancer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
21 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- participants diagnosed with solid tumor cancer who have completed cancer treatment at least 6 months;
- diagnosed with diabetes and/or hypertension for at least a year;
- aged 21 years or older,
- have an annual household incomes of below $50,000 for families of three,
- the average fatigue level within the past 7 days at the level of 3 or more on the 0 (no fatigue) to 10 (worse fatigue) Likert scale
- give informed consent.
Exclusion Criteria:
- currently undergoing treatment for cancer;
- have an active infection (e.g., fever, localized redness, swelling, sinus congestion);
- diagnosed with a psychological disorder (e.g., suicidal or homicidal tendencies, extreme anxiety or depression)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: The iHBE program group
Tailored Technology-Enhance Home-based exercise program (iHBE)
|
The tailored technology enhanced home-based exercise (iHBE) program is a 12-week program with 1 assessment home visit session, 5 home visits and 7 phone follow ups during exercise.
The technologies, a wearable device, and a smartphone application, will be used as a tool to monitor physical performance (heart rate [HR], step count), provide immediate feedback, send daily reminding message through Mobile Ecological Momentary Assessment (mEMA).
The coded raw data without personal identification information from the wearable device will be sent to the servers where the investigators can store it in the database alongside the mEMA data and create custom reports showing Heart Rate (HR) 30 minute before each Ecological Momentary Assessment (EMA) survey, showing HR and previous self-report responses before/ after each automatically triggered EMA.
Other Names:
|
No Intervention: Usual Care (Control group)
Participants were required to wear physical activity tracker (Fitbit) and respond to the daily symptoms survey (mEMA) while receiving usual care
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Fatigue as Assessed by Self-reported Fatigue Questionnaire
Time Frame: Pre- and post-intervention, up to 12 weeks
|
Patient-Reported Outcomes Measures Information System (PROMIS) Short Form V1.0-Fatigue 6a.
A 6-items; self-reported fatigue (frequency, duration, intensity) and the impact on physical, mental, and social activities, has five response options (1 or never to 5 or always).
The overall score range from 6 (no fatigue) to 30 (extreme fatigue).
Higher score means a greater fatigue
|
Pre- and post-intervention, up to 12 weeks
|
Change in Resilience as Assessed by Connor-Davidson Resilience Scale
Time Frame: Pre- and post-intervention, up to 12 weeks
|
Connor-Davidson Resilience scale: 10 item self-report rating scale 0 (not true at all) to 4 (true nearly all the time).
The overall score range from 0 (no resilience) to 40 (High Resilience).
The higher score means a better resilience
|
Pre- and post-intervention, up to 12 weeks
|
Change in Physical Well Being
Time Frame: Pre- and post-intervention, up to 12 weeks
|
Physical well being as assessed by 36 item self-report instrument.
The overall score derived from the physical functioning, role limitation-physical, and bodily pain domains.
The overall score range from 0-400, with a score 400 reflecting the highest rating of physical health.
|
Pre- and post-intervention, up to 12 weeks
|
Change in Mental Well Being
Time Frame: Pre- and post-intervention, up to 12 weeks
|
Mental component of the Short Form Survey (SF-36), the 36 item self-report instrument.
The overall score was derived from the mental health, and role limitation-emotional domains.
The total score range from 0 to 200, with a score of 200 indicating high mental well being
|
Pre- and post-intervention, up to 12 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Physical Activity
Time Frame: 12 weeks
|
The physical activity will be measured in a form of average step count/day measured by a wrist-worn wearable device.
|
12 weeks
|
Change in Brain-Derived Neurotrophic Factor Level (in Serum)
Time Frame: Pre-and post-intervention, up to 12 weeks
|
The level of Brain-Derived Neurotrophic Factor in serum was measured by ELISA.
The level will be measured in nanograms/milliliter.
|
Pre-and post-intervention, up to 12 weeks
|
Change in Brain-Derived Neurotrophic Factor Level (in Sweat)
Time Frame: Pre- and post-intervention, up to 12 weeks
|
Brain-Derived Neurotrophic Factor level in sweat collected through the sweat pad.
The level will be measured in nanograms/milliliter.
|
Pre- and post-intervention, up to 12 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 1, 2019
Primary Completion (Actual)
January 31, 2021
Study Completion (Actual)
June 30, 2021
Study Registration Dates
First Submitted
March 12, 2019
First Submitted That Met QC Criteria
March 12, 2019
First Posted (Actual)
March 14, 2019
Study Record Updates
Last Update Posted (Actual)
September 21, 2022
Last Update Submitted That Met QC Criteria
August 24, 2022
Last Verified
August 1, 2022
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- J1886
- P30NR018093-01 (U.S. NIH Grant/Contract)
- IRB00175781 (Other Identifier: JHM IRB)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
IPD Plan Description
The individual participant data (IPD) will not be shared with other researchers
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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