- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03986554
Swallowing Pressure Profiles in Healthy Adults
March 13, 2020 updated by: University of Florida
This study is designed to determine the impact of a pharyngeal High Resolution Manometry catheter on swallowing biomechanics
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
During pharyngeal High Resolution Manometry (pHRM) a small bore flexible catheter is introduced into the pharynx to detect intrabolus pressure and contact of pharyngeal structures during swallowing.
The presence of the catheter through the upper esophageal sphincter (UES) leads to a violation of its natural closed state.
It is not clear how this intrusion influences the swallowing biomechanics .
Hence, this project's goal is to identify how hyoid movement is altered during swallowing with the presence of a pHRM catheter in place.
Study Type
Interventional
Enrollment (Actual)
10
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Florida
-
Gainesville, Florida, United States, 32610
- UF Health at the University of Florida
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 45 years (Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- healthy adults between the ages of 18-45 with no major medical conditions.
- no specific gender or race will be excluded or targeted for participation in this study.
Exclusion Criteria:
- adults who are pregnant
- adults with swallowing impairment, brain injury, deviated septum, G.I. strictures, obstructions, or Zenker's diverticulum, surgeries to nose, neck, or throat, or bleeding disorders will be excluded from this study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Randomization Visit A
Participants enrolled in this arm will consume 300ml of water over 60 minutes.
Each session will consist of 30 swallows broken into three 10-swallow sequences of 10ml of water.
Each sequence will be use VFSS to visualize swallows.
|
The Swallowing Systems Core laboratory is fully equipped to perform VFSS with a C-arm (OEC 9900) that is dedicated solely for research purposes.
VFSS recordings will be kept to a minimum and only turned on during the execution of each swallow in all sequences.
Video recording and images captured during the VFSS will be synced and saved to a secure server for data analysis.
VFSS allows for time-synced, frame-by-frame data analysis for the specific measures taken during swallowing tasks.
The physiological swallowing measures (temporal and kinematic movement of the hyolaryngeal complex during swallowing) cannot be visualized with any other technique.
Patients will swallow only water.
Aspiration (bolus into trachea) is not expected to occur during this study given that the individuals recruited will have no prior history of disease or disorder, and aspiration is uncommon in healthy individuals.
Other Names:
|
Other: Randomization Visit B
Participants enrolled in this arm will consume 300ml of water over 60 minutes.
Each session will consist of 30 swallows broken into three 10-swallow sequences of 10ml of water.
Sequences 1 and 3 will use videofluoroscopy only, while sequence 2 will use VFSS with simultaneous pharyngeal high resolution manometry in order to visualize swallows.
|
The Swallowing Systems Core laboratory is fully equipped to perform VFSS with a C-arm (OEC 9900) that is dedicated solely for research purposes.
VFSS recordings will be kept to a minimum and only turned on during the execution of each swallow in all sequences.
Video recording and images captured during the VFSS will be synced and saved to a secure server for data analysis.
VFSS allows for time-synced, frame-by-frame data analysis for the specific measures taken during swallowing tasks.
The physiological swallowing measures (temporal and kinematic movement of the hyolaryngeal complex during swallowing) cannot be visualized with any other technique.
Patients will swallow only water.
Aspiration (bolus into trachea) is not expected to occur during this study given that the individuals recruited will have no prior history of disease or disorder, and aspiration is uncommon in healthy individuals.
Other Names:
This procedure will only take place once during sequence 2 of the randomization B session.
If desired, a small amount (< 0.5 mL) of topical 2% viscous lidocaine hydrochloride will be applied to the participant's nostril of choice prior to catheter insertion.
The catheter will be placed through the nasal passage, oropharynx, and hypopharynx to the esophagus.
Correct catheter placement will be verified with VFSS.
With the catheter in place, the subject will perform 10 swallows of 10ml and is expected to take approximately 2.5 minutes.
The catheter will then be removed and the subject will move on to sequence 3. Individuals have the option to decline this procedure if it is uncomfortable or difficult to tolerate.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in peak anterior and superior hyoid movement
Time Frame: Baseline; Week 1
|
peak hyoid movement (mm)
|
Baseline; Week 1
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Emily K Plowman, PhD, University of Florida
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 9, 2019
Primary Completion (Actual)
July 19, 2019
Study Completion (Actual)
July 19, 2019
Study Registration Dates
First Submitted
June 13, 2019
First Submitted That Met QC Criteria
June 13, 2019
First Posted (Actual)
June 14, 2019
Study Record Updates
Last Update Posted (Actual)
March 17, 2020
Last Update Submitted That Met QC Criteria
March 13, 2020
Last Verified
March 1, 2020
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- IRB201901651
- OCR24403 (Other Identifier: UF OnCore)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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