- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04018820
Effects of a 12-week Strength Training Program in Men With Myotonic Dystrophy Type 1
December 6, 2021 updated by: Élise Duchesne
Eleven men with myotonic dystrophy type 1 (DM1) underwent a 12-week lower-limb strength training program.
The training program consisted of 3 series of 6 to 8 maximal repetitions of 5 different exercises: Leg extension, leg press, hip abduction, squat and plantar flexion.
Training sessions were closely supervised and took place twice a week.
It is hypothesised that the training program will induce muscular hypertrophy despite the genetic defect.
The training program should also have positive effects on function.
The participants were evaluated at baseline, week 6, week 12, month 6 and month 9 to see the effects of the training program and if these effects are maintained over time.
Study Overview
Study Type
Interventional
Enrollment (Actual)
11
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Quebec
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Saguenay, Quebec, Canada, G7X 7X2
- Groupe de recherche interdisciplinaire sur les maladies neuromusculaires
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
30 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- DM1 diagnosis must be confirmed by genetic analysis;
- Male gender, aged between 30 and 65 years old;
- Be able to walk without assistance;
- Consent of the neurologist must be given to participate in this study;
- Must reside in the Saguenay-Lac-St-Jean region;
- Subjects must be able to give their consent freely and voluntarily.
Exclusion Criteria:
- Patients with any other form of muscular dystrophy are excluded;
- Any contraindication for strenuous exercise or muscle biopsy.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: N/A
- Interventional Model: Sequential Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Training program
|
12-week strength training program of the lower limbs consisting of 5 different exercises: Leg extension, leg press, hip abduction, squat and plantar flexion.
All exercises were performed between 6 and 8 maximal repetitions.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in maximal isometric muscle strength of the knee extensors
Time Frame: At baseline, week 6, week 12, month 6 and month 9
|
Changes in maximal isometric muscle strength of the knee extensors measured by quantified muscle testing using a handheld dynamometer
|
At baseline, week 6, week 12, month 6 and month 9
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in maximal isometric muscle strength of the knee flexors
Time Frame: At baseline and week 12
|
Changes in maximal isometric muscle strength of the knee flexors measured by quantified muscle testing using a handheld dynamometer
|
At baseline and week 12
|
Changes in maximal isometric muscle strength of the hip flexors
Time Frame: At baseline and week 12
|
Changes in maximal isometric muscle strength of the hip flexors measured by quantified muscle testing using a handheld dynamometer
|
At baseline and week 12
|
Changes in maximal isometric muscle strength of the hip extensors
Time Frame: At baseline and week 12
|
Changes in maximal isometric muscle strength of the hip extensors measured by quantified muscle testing using a handheld dynamometer
|
At baseline and week 12
|
Changes in maximal isometric muscle strength of the ankle dorsiflexors
Time Frame: At baseline and week 12
|
Changes in maximal isometric muscle strength of the ankle dorsiflexors measured by quantified muscle testing using a handheld dynamometer
|
At baseline and week 12
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Changes in 1-repetition maximum strength of the leg extension exercise
Time Frame: At baseline, week 6 and week 12
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Changes in 1-repetition maximum strength of the leg extension exercise
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At baseline, week 6 and week 12
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Changes in 1-repetition maximum strength of the leg press exercise
Time Frame: At baseline, week 6 and week 12
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Changes in 1-repetition maximum strength of the leg press exercise
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At baseline, week 6 and week 12
|
Changes in 1-repetition maximum strength of the hip abduction exercise
Time Frame: At baseline, week 6 and week 12
|
Changes in 1-repetition maximum strength of the hip abduction exercise
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At baseline, week 6 and week 12
|
Changes in 1-repetition maximum strength of the squat exercise
Time Frame: At baseline, week 6 and week 12
|
Changes in 1-repetition maximum strength of the squat exercise
|
At baseline, week 6 and week 12
|
Changes in comfortable walking speed in the 10-meter walk test
Time Frame: At baseline, week 6, week 12, month 6 and month 9
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Changes in comfortable walking speed in the 10-meter walk test
|
At baseline, week 6, week 12, month 6 and month 9
|
Changes in maximal walking speed in the 10-meter walk test
Time Frame: At baseline, week 6, week 12, month 6 and month 9
|
Changes in maximal walking speed in the 10-meter walk test
|
At baseline, week 6, week 12, month 6 and month 9
|
Changes in the number of repetitions in the 30-seconds sit-to-stand test
Time Frame: At baseline, week 6, week 12, month 6 and month 9
|
Changes in the number of repetitions in the 30-seconds sit-to-stand test
|
At baseline, week 6, week 12, month 6 and month 9
|
Changes in the score of the lower extremity functional scale
Time Frame: At baseline, week 12, month 6 and month 9
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Changes in the score of the lower extremity functional scale (LEFS).
The LEFS is an 80-point questionnaire with 20 items scored from 0 to 4. A score of 80 means no disfunction while a score of 0 means maximal disfunction.
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At baseline, week 12, month 6 and month 9
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Changes in the score of the myotonic dystrophy health index
Time Frame: At baseline, week 6, week 12, month 6 and month 9
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Changes in the score of the myotonic dystrophy health index (MDHI).
The MDHI is a 114-item questionnaire scored from 0 to 100, where 0 means no disability and 100 means maximal disability.
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At baseline, week 6, week 12, month 6 and month 9
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Changes in the score of the Fatigue and Daytime Sleepiness Scale
Time Frame: At baseline, week 6, week 12, month 6 and month 9
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Changes in the score of the Fatigue and Daytime Sleepiness Scale (FDSS).
The FDSS is a 12-item questionnaire where all questions are scored from 0 to 2. A higher score means more daytime sleepiness and fatigue.
|
At baseline, week 6, week 12, month 6 and month 9
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Changes in the Marin apathy scale
Time Frame: At baseline, week 12, month 6 and month 9
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Changes in the Marin apathy scale.
The Marin apathy scale is scored by the clinician where he interviews the subject and then scores an 18-item list on a scale of 1 to 4. A high score means more apathy.
|
At baseline, week 12, month 6 and month 9
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Changes in the Well-Being Manifestations Measure Scale
Time Frame: At baseline, week 6, week 12 and month 6
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Changes in the Well-Being Manifestations Measure Scale (WBMMS).
The WBMMS is a 25-item questionnaire where each question is scored on a scale from 1 to 5. A high score means high well-being.
|
At baseline, week 6, week 12 and month 6
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Changes in the Hospital Anxiety and Depression Scale
Time Frame: At baseline, week 6, week 12 and month 6
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Changes in the Hospital Anxiety and Depression Scale (HADS).
The HADS is a 14-item questionnaire with a scale from 0 to 3 for each item.
A high score means high depression and anxiety.
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At baseline, week 6, week 12 and month 6
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Changes in muscle biopsy of the vastus lateralis: muscle fiber typing
Time Frame: At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: muscle fiber typing
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At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: muscle fiber size
Time Frame: At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: muscle fiber size (smallest diameter of the fiber)
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At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: muscle proteomics
Time Frame: At baseline and week 12
|
Changes in muscle biopsy of the vastus lateralis: muscle proteomics (protein expression)
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At baseline and week 12
|
Changes in muscle biopsy of the vastus lateralis: muscle transcriptomics
Time Frame: At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: muscle transcriptomics (RNA expression analysis)
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At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: mitochondrial function
Time Frame: At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: mitochondrial function.
Analysis of mitochondrial markers and enzymes
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At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: Nuclear foci
Time Frame: At baseline and week 12
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Changes in muscle biopsy of the vastus lateralis: Nuclear foci (changes in accumulation of nuclear foci)
|
At baseline and week 12
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Elise Duchesne, Ph.D., Université du Québec à Chicoutimi
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 1, 2017
Primary Completion (Actual)
June 22, 2018
Study Completion (Actual)
June 22, 2018
Study Registration Dates
First Submitted
July 9, 2019
First Submitted That Met QC Criteria
July 9, 2019
First Posted (Actual)
July 15, 2019
Study Record Updates
Last Update Posted (Actual)
December 15, 2021
Last Update Submitted That Met QC Criteria
December 6, 2021
Last Verified
December 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2017-005
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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