- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04037982
RCT Study on Safety of LPD and OPD in the Treatment of Periampullary Tumors
July 28, 2019 updated by: Zhongtao Zhang, Beijing Friendship Hospital
A Randomized Controlled Study on the Safety of Total Laparoscopy and Traditional Open Pancreaticoduodenectomy in the Treatment of Periampullary Tumors
Pancreaticoduodenectomy (PD) is considered one of the most complex and dangerous procedures in general surgery.
This procedure is the preferred surgical procedure for treating tumors around the ampulla.
Traditional open pancreaticoduodenectomy (OPD) has brought great surgical trauma to patients while treating diseases.
In 1994, Gagner et al first reported laparoscopic pancreaticoduodenectomy (LPD).
With the development of laparoscopic techniques, the updating of devices, and the continuous accumulation of laparoscopic gastrointestinal surgery experience, the results of retrospective studies published show that there is no significant difference in safety between LPD and OPD.
However, the results of the recently published RCT study show that the mortality associated with LPD complications is five times greater than that of OPD.
At present, the security of LPD has been controversial.
Therefore we conducted a prospective randomized controlled trial with a primary outcome of perioperative complications, providing evidence-based results for the safe and effective clinical development of LPD.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
102
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Beijing, China
- Beijing Friendship Hospital, Capital Medical University
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 68 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Preoperative imaging diagnosis of periampullary tumor, or preoperative pathological diagnosis of periampullary tumor, preoperative evaluation can be performed pancreaticoduodenectomy; Serum bilirubin was less than 100 μ mol/L before operation; Sign a written informed consent form and agree to be randomly divided into groups for surgical treatment.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: LPD
In this group, patients will undergo laparoscopic pancreaticoduodenectomy.
|
During laparoscopic surgery, the surgeon makes several smaller incisions in your abdomen and inserts special instruments, including a camera that transmits video to a monitor in the operating room.
The surgeon watches the monitor to guide the surgical tools in performing the Whipple procedure.
Laparoscopic surgery is a type of minimally invasive surgery.
|
Active Comparator: OPD
In this group, patients will undergo open pancreaticoduodenectomy.
|
During an open procedure, your surgeon makes an incision in your abdomen in order to access your pancreas.
This is the most common approach and the most studied.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Incidence of complications
Time Frame: 30 days after operation
|
The patients number with complications / The total number in this group
|
30 days after operation
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
August 1, 2019
Primary Completion (Anticipated)
December 1, 2022
Study Completion (Anticipated)
December 1, 2022
Study Registration Dates
First Submitted
July 28, 2019
First Submitted That Met QC Criteria
July 28, 2019
First Posted (Actual)
July 30, 2019
Study Record Updates
Last Update Posted (Actual)
July 30, 2019
Last Update Submitted That Met QC Criteria
July 28, 2019
Last Verified
July 1, 2019
More Information
Terms related to this study
Other Study ID Numbers
- CR-LPD
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Yes
IPD Sharing Supporting Information Type
- Study Protocol
- Statistical Analysis Plan (SAP)
- Clinical Study Report (CSR)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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