- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04119271
Durham Healthy Breathing in Healthy Homes Project (DHBHH)
Durham Healthy Breathing in Healthy Homes Project: A Duke-Reinvestment Partners Collaborative
To determine if Home-based Environmental Interventions (HEI) that improve home air-quality problems can improve asthma outcomes. Participants will benefit through home-based environmental interventions that improve home air-quality problems and improve asthma outcomes. All participants will receive a Breath Easy at Home Kit, which could help with reducing environmental exposures. The primary objective is to assess the feasibility and acceptability of the HEI measured by the proportion of families completing intervention components and proportion of caregivers expressing satisfaction with intervention components. Secondary objective is to explore the efficacy of a HEI on reducing environmental exposures measured using personal wristband monitors.
Exploratory objective is improvements in asthma control following HEI measured using asthma control scores and lung function. The fourth objection is to explore correlations between demographics, body weight, housing characteristics (smokers, electronic cigarette use, number of pets, housing type) with measures of acceptability, satisfaction and improved exposure markers.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Nedenia C Parker, BS
- Phone Number: 919-684-6127
- Email: nedenia.parker@duke.edu
Study Locations
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North Carolina
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Durham, North Carolina, United States, 27710
- Duke University Medical Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Parent/legal guardian has provided informed consent (child has provided assent if needed)
- 5-16 years of age with physician-diagnosed asthma
- Evidence of poor asthma control defined as either:
Hospitalization at Duke Children's Hospital within past 30 days or, ACQ6 > 1.0 during ambulatory visit to Duke Asthma Center within 2 weeks
Exclusion Criteria:
- Lack of informed consent
- Any major chronic illness that in the opinion of the PI would interfere with participation in the intervention or completion of the study procedures
- Inability to complete baseline measurements in a satisfactory manner according to the judgment of the research coordinator or PI
- Family is planning to move households in the next 2 months
- Parent/Caregiver unable to consent in English
- Sensitivity or allergy to silicone
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Breathe Easy at Home Kit Products
Families will be provided with a Breathe Easy at Home Kit. These kits will include: a HEPA filtered upright vacuum cleaner, a HEPA-filtered Air Purifier, a Hypoallergenic latex free mattress cover, box spring cover, and two pillow covers, Healthier alternative to most household cleaners, Non- toxic glue type pest control devices for rodent control, and a combination of safe products to locate and kill roaches. |
HEPA filtered upright vacuum cleaner, HEPA-filtered Air Purifier, Hypoallergenic latex free mattress cover, box spring cover, and two pillow covers, Healthier alternative to most household cleaners, Non- toxic glue type pest control devices for rodent control and a combination of safe products to locate and kill roaches.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Number of completed home visits as measured by completion logs
Time Frame: 2 months
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2 months
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Number of completion of the post-intervention phone visit as measured by call logs
Time Frame: Four Months
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Four Months
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Number of caregiver reporting satisfaction with intervention as measured by survey responses
Time Frame: Four Month
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Four Month
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Environmental Wristband Markers
Time Frame: 3 weeks and 7 weeks
|
changes in targeted environmental wristband markers of exposure to organic contaminants in the home environment, including phthalates, organophosphate esters, several pesticides, and polyaromatic hydrocarbon (PAH) markers evaluated using personal silicone wristband monitors.
Paired t-tests (or Wilcoxon signed rank tests for non-parametric data) will be used to assess post-intervention changes in targeted wristbands toxin levels.The relationship between changes in these outcomes and measures of intervention adherence will be analyzed using Pearson correlations and ANOVA trend testing as appropriate.
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3 weeks and 7 weeks
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Change in Indoor Air Quality measured by questionnaire
Time Frame: 3 weeks and 7 weeks
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Sponsor developed questionnaire-15 to 20 questions asking about air quality.
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3 weeks and 7 weeks
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Change in Asthma Symptoms
Time Frame: 1 week and 4 months
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Change in asthma symptom control measured by the asthma control questionnaire 6 (ACQ6) (ambulatory participants only).
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1 week and 4 months
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Change in Spirometry Values as measured by spirometric measures
Time Frame: 1 week and 4 months
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Impulse Oscillometry (IOS) simply requires the child to breathe in and out through a mouthpiece for 20-30 seconds.
During breathing, a loudspeaker delivers a quiet pulse-shaped pressure-flow signal to the respiratory system.
Spirometric measures is the forced vital capacity (FVC),
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1 week and 4 months
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Change in Asthma Symptoms
Time Frame: 1 week and 4 months
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Improvements in asthma control following HEI measured using asthma control scores and lung function.
For patients enrolled in the ambulatory setting, change in FEV1, FEV1/FVC by spirometry will be calculated.
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1 week and 4 months
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Change in Spirometry Values as measured by spirometric measures
Time Frame: 1 week and 4 months
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The Spirometer measure is theforced expiratory volume in 1 second (FEV1),
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1 week and 4 months
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Change in Spirometry Values as measured by spirometric measures
Time Frame: 1 week and 4 months
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The Spirometeric Measure is the FEV1/FVC ratio
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1 week and 4 months
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Change in Spirometry Values as measured by spirometric measures
Time Frame: 1 week and 4 months
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The Spirometric Measure is the forced expiratory flow average over 25-75% of FVC (FEF25-75).
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1 week and 4 months
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Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Jason E Lang, MD, MPH, Duke University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Pro00102762
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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