Effect of Intranasal Insulin on Postoperative Cognitive Dysfunction in Middle Aged Patients Undergoing Non Cadiac Surgery.

Effect of Intranasal Insulin on Postoperative Cognitive Dysfunction

Sponsors

Lead sponsor: Minia University

Source Minia University
Brief Summary

Our study is designed to evaluate the effect of intranasal insulin on postoperative cognitive dysfunction.

Primary outcome:

1. The occurrence of cognitive dysfunction at approximately 7 days after surgery.

Secondary outcome:

1. Incidence of any side effect.

Overall Status Recruiting
Start Date February 25, 2019
Completion Date December 25, 2019
Primary Completion Date December 25, 2019
Study Type Observational
Primary Outcome
Measure Time Frame
Cognitive dysfunction 7 days
Enrollment 57
Condition
Intervention

Intervention type: Drug

Intervention name: Intranasal insulin

Description: Surgical group Received intranasal insulin, the second group surgical Received placebo and the third group is non surgical do not receive anything.

Arm group label: Surgical group Received intranasal insulin.

Eligibility

Sampling method: Non-Probability Sample

Criteria:

Inclusion Criteria:

1. Age 40 - 60 years.

2. Both gender.

3. Patients will be scheduled for elective major abdominal, thoracic, orthopedic, open gynecological, open urological, spine, otolaryngological surgeries under general anesthesia with expected hospital stay >4 days.

Exclusion Criteria:

- 1. Drug allergy. 2. Patients with major psychiatric disease. 3. Patients receive major tranquillizers and antidepressant. 4. Those undergoing neurosurgery or cardiac surgery. 5. Those unable or unwilling to abide by the study procedure 6. Those who could not follow procedure or who had poor comprehension of dutch language. 7. Those with sever visual and auditory disorder / handicaps.

Gender: All

Minimum age: 40 Years

Maximum age: 60 Years

Healthy volunteers: Accepts Healthy Volunteers

Overall Contact

Last name: Nourhan Mohamed Anter

Phone: 01100418846

Phone ext: 01012660236

Email: [email protected]

Location
facility status contact
Minia University | Minya, 61111, Egypt Recruiting Nourhan NM Mohamed Anter, Resident 01100418846 [email protected]
Minia university | Minya, 61111, Egypt Completed
Location Countries

Egypt

Verification Date

November 2019

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: Minia University

Investigator full name: Nourhan mohamed anter

Investigator title: Resident of anesthesia and Intensive care

Has Expanded Access No
Condition Browse
Arm Group

Arm group label: Control group.

Arm group label: Surgical group Received intranasal insulin.

Arm group label: Surgical group Received placebo.

Patient Data Yes
Study Design Info

Observational model: Case-Control

Time perspective: Prospective

Source: ClinicalTrials.gov