- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04329091
Implications of Anesthetics on Sleep Consolidation
Sleep leads to consolidation of learning in humans, restoring memories that were forgotten over a waking day and protecting memories against future forgetting. Although theories of consolidation have linked sleep spindles seen on electroencephalography to consolidation due to their putative role in hippocampal transfer to the neocortex (Antony et al, 2019; Antony & Paller, 2017), spindles have not yet been linked to consolidation of perceptual learning or generalized learning. Prior research by a collaborator on this project has shown that sleep specifically aids in the consolidation of generalized perceptual learning of speech (Fenn, Nusbaum, & Margoliash, 2003). Subjects show a 10-point reduction in performance after a waking retention period, while no loss is found after a retention period containing sleep (Fenn et al., 2003).
Various measurable activities in the brain are associated with memory consolidation during sleep. This project intends study the effect of dexmedetomidine on memory consolidation during sleep
Hypothesis 1 The gain in perceptual learning after a 90 minute natural sleep nap will also occur after 90 minutes of a sufficient dose of IV dexmedetomidine to replicate sleep. This result would suggest that consolidation can occur under this anesthetic state of consciousness.
Hypothesis 2 The number and quality of sleep spindles seen on EEG in subjects administered dexmedetomidine will correlate with this gain in perceptual learning. This result would suggest that biomimetic sleep spindles are sufficient for producing memory consolidation.
Only those subjects capable of giving their own consent will be considered for this study.
The study will enroll 20 healthy subjects for this study between the ages of 18 and 35.
All volunteers will be fit and healthy, meeting the American Society of Anesthesiologists (ASA) physical status classification ASA 1 (normal healthy subjects) and ASA 2 (stable chronic condition) and of normal body habitus. Prior to the study enrollment, each volunteer will sign an informed consent form. A standard anesthetic medical history will be taken in addition to performing a focused standard pre-anesthetic physical examination in order to rule out active and chronic medical problems.
Study Overview
Study Type
Enrollment (Actual)
Phase
- Phase 4
Contacts and Locations
Study Locations
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Illinois
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Chicago, Illinois, United States, 60637
- University of Chicago Medicine
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Primary Inclusion Criteria for "Healthy" volunteers
- Age between 18-35
- Native English speaking
- No hearing or speech difficulties
- No psychiatric, neurologic, or sleep disorders
- No chronic medical conditions, as reflected below under Primary Exclusion Criteria and above in 'Medical History'
- Non-smokers (within 3 months)
- Non-users of recreational or illicit drugs (including marijuana)
- Must be willing and able to pass the drug tests (no psychoactive substances), no ingestion of alcohol or sleep-altering drugs for the 48 hours prior to the study session.
- Normal weight
Primary Exclusion Criteria for "Healthy" volunteers
- Speech difficulties/disorders
- Hearing difficulties (including occluded or infected ear canals)
- Current hairstyles that do not allow the high-density EEG cap to make contact with the scalp (e.g., individuals with hair extensions, braids, dreadlocks or hairstyles that restrict the ability of electrodes to touch the scalp)
- Metal on/in/near their heads (including jewelry) that cannot be removed for the duration of the study
- Metal implants
- Serious abusers of alcohol or caffeine.
- Existing or suspected psychological or neurological disorders
- Pregnancy or suspected pregnancy (urine pregnancy test at visit 2)
- Chronic or transient (e.g., jet lag) problems with sleep; suspected sleep disorder
Abnormal sleep habits, such as:
- Sleeping less than 5 hours each night
- Going to sleep before 8:00 PM or after 2:00 AM on a regular basis
- Waking up before 5:00 AM or after 10:00 AM on a regular basis.
- Currently taking medications that regulate blood pressure; a history of high blood pressure, diabetes or stroke
- Chronic smokers
- Current use of aspirin, or other medications which increase bleeding, prior to the study session.
- Known drug allergies to anesthetics or a history of an adverse reaction to anesthesia.
- Known allergy to adhesives or electrode gel
- Medication that alters sleep, cognitive function, or both
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: Dexmedetomidine Arm
Dexmedetomidine: Administration of a 0.5 mcg/kg bolus followed by an infusion of 0.5-0.7 mcg/kg/hr, titrated up by 0.1 mcg every 1 minute until the subject spontaneously closes his or her eyes.
When the subject spontaneously closes his or her eyes the infusion continues for 90 minutes from that point.
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All subjects will receive Dexmedetomidine to induce sedation between their pre-sedation and post-sedation perceptual learning tests.
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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Perceptual Learning Protocol
Time Frame: 1 day
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Subjects are tested in the morning for word recognition on hard-to-understand speech, then trained on this speech (never hearing the same words twice) which produces about 20 percentage points of improvement.
After sedation subjects are re-tested.
During the morning, afternoon and evening post-tests, subjects will be tested on new spoken words.
At each time point where the perceptual learning protocol is administered the number of words correctly perceived out of 50 will be measured.
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1 day
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Anna Clebone, MD, University of Chicago
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Adrenergic Agents
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Analgesics, Non-Narcotic
- Adrenergic alpha-2 Receptor Agonists
- Adrenergic alpha-Agonists
- Adrenergic Agonists
- Hypnotics and Sedatives
- Dexmedetomidine
Other Study ID Numbers
- IRB19-1442
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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