- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04371029
Impact of Neck Inspiratory Muscle Activation During Sleep in ICU Patients After a COVID 19 ARDS (COVISLEEP)
June 4, 2021 updated by: University Hospital, Bordeaux
Most patients in intensive care units (ICUs) experience severe sleep disruption.
Sleep disruption and sleep alteration may have an influence on the ability to breathe spontaneously.
But, the cause of altered sleep remains unknown.
Previous studies have shown that decreasing nocturnal respiratory muscle activity through mechanical ventilation might improve sleep quality.
Nocturnal respiratory muscle activity may be one of the potential factor which contribute to alter sleep in the ICU.
Therefore, the aim of this study is to analyse the presence of NIM activation during the night and it's consequence in an ICU population with the same pathology (COVID 19 ARDS).
Study Overview
Detailed Description
Sleep alteration is a common problem among ventilated ICU patient.
About one third of the patient have abnormal EEG pattern which cannot be scored by using the AASM standard criteria.
Patients experience marked fragmentation, absence of deep sleep, and REM sleep is decreased, .
It has been shown that sleep deprivation has a negative impact on respiratory muscle endurance.
So a good sleep is essential when the respiratory system is being challenged, as in the ICU during the weaning period.
Indeed, in the ICU, patients with altered sleep, had a markedly longer weaning duration than in patients with normal sleep, and are more likely to fail a spontaneous breathing trial.
Many factors may influence the quality of sleep in the ICU (noise, medication, mechanical ventilation …) but few studies have focus on the cause of this altered sleep, and the cause of altered sleep remains unknown.
Previous studies have shown that decreasing nocturnal respiratory muscle activity through mechanical ventilation might improve sleep quality.
Mechanical ventilation can decrease the charge imposed on the respiratory pump, and allows muscle to rest.
Indeed, when the charge is too high (for example after an ARDS during the weaning period), the diaphragm may be overloaded, and there could be a greater involvement of other inspiratory muscles in breathing.
In other pathological condition, the neck inspiratory muscle activity is increased (e.g.
COPD, amyotrophic lateral sclerosis), and sometimes this activity persist during sleep with marked degradation in sleep architecture.
Nocturnal respiratory muscle activity may be one of the potential factor which contribute to alter sleep in the ICU.
Ttherefore, the aim of tis study is to analyse the presence of NIM activation during the night and it's consequence in an ICU population with the same pathology (COVID 19 ARDS).
Study Type
Interventional
Enrollment (Actual)
17
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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-
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Bordeaux, France, 33000
- Hôpital Pellegrin
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patient above 18 year-old admitted to intensive care unit
- COVID-19 assessed by PCR on nasopharyngeal swab or pulmonary sample
- Oro-tracheal intubation for mechanical ventilation
Exclusion Criteria:
- Guardianship or curatorship
- Prisoners
- No health insurance
- Pregnancy
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: OTHER
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Experimental
A Polysomnography (PSG) will be performed in all patient the night before extubation, the day prior discharge and 3 month after.
Recording will consist in EEG, EOG et EMG of the chin.
We will record NIM EMG.
We will also performed an actimetry during hospitalization in the post ICU ward.
A quality of sleep questionnaire (Pittsburgh questionnaire) will be completed by the patients during the visit at 3 month.
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Polysomnography at 3 times, actimetry measure and Pittsburgh questionnaire
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Proportion of patients with altered spleep
Time Frame: At day 10 after inclusion
|
Comparison between patients with NIM activation during the night and patients without NIM activation during the night, in patients COVID 19 ARDS with altered spleep.
A Polysomnography (PSG) will be performed the night before extubation.
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At day 10 after inclusion
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Sleep architecture at hospital discharge
Time Frame: At day 28 after inclusion
|
Thanks to a PSG the night befor discharge, the seep architecture will be estimated.
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At day 28 after inclusion
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Sleep monitoring during hospital stay after ICU discharge
Time Frame: At day 18 after ICU discharge
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Thanks to actimetry measure during hospitalization in the post ICU ward.
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At day 18 after ICU discharge
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Sleep quality
Time Frame: 3 months after hospiotal discharge
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Sleep quality will be evaluate by the Pittsburgh sleep quality index.
The 7 components of the score add up for give an overall score ranging from 0 to 21 points, 0 meaning that there is no difficulty, and 21 indicating on the contrary major difficulties.
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3 months after hospiotal discharge
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Sleep architecture at month-3
Time Frame: 3 months after hospital discharge
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Thanks to a PSG at 3 months, the seep architecture will be estimated.
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3 months after hospital discharge
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Cost of ICU hospitalization
Time Frame: From inclusion to ICU discharge, up to 10 days after inclusion
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all cost will be estimated during ICU hospitalization.
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From inclusion to ICU discharge, up to 10 days after inclusion
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
April 28, 2020
Primary Completion (ACTUAL)
September 9, 2020
Study Completion (ACTUAL)
December 9, 2020
Study Registration Dates
First Submitted
April 28, 2020
First Submitted That Met QC Criteria
April 30, 2020
First Posted (ACTUAL)
May 1, 2020
Study Record Updates
Last Update Posted (ACTUAL)
June 7, 2021
Last Update Submitted That Met QC Criteria
June 4, 2021
Last Verified
June 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CHUBX 2020/14
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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