- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04393740
Contribution of Posterior Corneal Astigmatism to Total Corneal Astigmatism in a Sample of Egyptian Population
The Contribution of Posterior Corneal Astigmatism to Total Corneal Astigmatism Using Scheimpflug Analyzer (Pentacam ) in a Sample of Egyptian Population
The magnitude of posterior corneal astigmatism was considered negligible due to the smaller difference in the refractive index between the cornea and the aqueous .
though ,neglecting the posterior corneal astigmatism lead to errors during calculation of the toric iols (over or under estimation ) .
so we aim to determine the percentage of contribution of posterior corneal astigmatism to total corneal astigmatism in a sample of Egyptian population using scheimpflug imaging (Pentacam ).
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Astigmatism is a common vision condition that causes blurred vision. Astigmatism is an error of refraction in which incident parallel rays can't be focused to a single point .It could be corneal or lenticular astigmatism or both . Regarding Corneal astigmatism it is due to difference in the corneal curvature in the different meridian of both the anterior and posterior surface .
The are 2 methods of studing corneal curvature :
- Corneal topography which depend on placcido disc to study anterior corneal surface .
- Corneal tomography is more precise in detecting anterior and posterior corneal curvature depending on Scheimpflug principle which uses a rotating Scheimpflug camera .
Pentacam is a device which depend on Scheimpflug technique .
The importance of studing the posterior corneal curvature includes :
• The posterior corneal curvature is a more sensitive indicator of early keratoconus detection especially posterior corneal elevation.
Previously, The change in the posterior corneal surface plays a more subtle role than the anterior corneal surface in optical performance because of the smaller difference in refractive indices between the cornea and aqueous, and it has been thought that the magnitude of PCA in the normal population is clinically negligible.
Posterior corneal astigmatism (PCA) is important for better predictability of toric intraocular lens calculation to avoid under- or overestimation of toricity in intraocular lens (IOL) power calculations.
But recently it has been demonstrated how neglecting PCA will lead to overcorrection of astigmatism in eyes with with-the-rule astigmatism (WTR) and undercorrection in eyes with against-the-rule astigmatism (ATR).(3) In our study we aim to Determine the contribution of posterior corneal astigmatism to total corneal astigmatism and the error in estimating total corneal astigmatism from anterior corneal measurements only using Scheimpflug analyzer (Pentacam ).
Our patients will undergo Scheimpflug imaging using pentacam .
From the corneal parameters displayed in pentacam we can calculate :
- Anterior corneal astigmatism by substracting Ksteep -Kflat on the front surface
- Posterior corneal astigmatism by substracting Ksteep-Kflat on the back surface.
- Total corneal astigmatism is calculated by addition of anterior and posterior corneal astigmatism using vector analysis by using ASSORT vector calculator.*
- The percentage of contribution of posterior corneal astigmatism to magnitude of Total corneal astigmatism is then calculated .
ASSORT vector calculator:
Is a total planning and outcomes analysis software for astigmatism using Alpins method ,cheltman ,Victoria ,Australia .
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: alaa mo badawy, Msc
- Phone Number: +20 01008858267
- Email: alaabadawy93@gmail.com
Study Contact Backup
- Name: sarah A Azzam, MD
- Phone Number: +20 01227425601
- Email: Sarahazzam@ymail.com
Study Locations
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-
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Cairo, Egypt
- Recruiting
- kasr El Aini medical school
-
Contact:
- sarah A Azzam, MD
- Phone Number: +20 01227425601
- Email: Sarahazzam@ymail.com
-
Contact:
- alaa MO badawy, Msc
- Phone Number: +20 0100858267
- Email: alaabadawy93@gmail.com
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients with corneal astigmatism(±0.5D up tp ±4 D )
- Age (18-45 years )
- Refractive error (myopia up to -8D)
- Hyperopia up to +4
- Patients who have clear cornea .
- Good quality Scheimpflug analyzer scans.
Exclusion Criteria:
- Patients who have any corneal opacity .
- Patients who underwent any Previous corneal surgery .
- Patients who have Co existing corneal pathology.
- Glaucomatus patients.
- Patients with any Concomitant ocular disease .
- Patients with History of previous ocular trauma .
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Cross-Sectional
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
contribution of posterior corneal astigmatism to magnitude of total corneal astigmatism
Time Frame: 3 months
|
to detect the contribution of posterior corneal astigmatism to total corneal astigmatism to avoid errors during calculation of toric Intra ocular lenses
|
3 months
|
Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Ferreira TB, Ribeiro P, Ribeiro FJ, O'Neill JG. Comparison of Methodologies Using Estimated or Measured Values of Total Corneal Astigmatism for Toric Intraocular Lens Power Calculation. J Refract Surg. 2017 Dec 1;33(12):794-800. doi: 10.3928/1081597X-20171004-03.
- Rydstrom E, Westin O, Koskela T, Behndig A. Posterior corneal astigmatism in refractive lens exchange surgery. Acta Ophthalmol. 2016 May;94(3):295-300. doi: 10.1111/aos.12965. Epub 2016 Jan 30.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Ms-184-2019
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Supporting Information Type
- Study Protocol
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
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