- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04582175
Comparison Between Two Revascularization Strategies in MVD Patients With Uncomplicated ST-elevation MI (Promise)
October 8, 2020 updated by: Nichita-Brendea Mihnea-Traian, University of Oradea
A Retrospective, One Center Comparison of Outcomes Between Complete Revascularization by PCI at the Time of PPCI or During the Index Hospital Admission in One Hundred MVD Patients With ST-elevation MI Uncomplicated by Cardiogenic Shock
The study aimed to compare major adverse cardiac and cerebrovascular events(MACCE) and mortality at one year between two strategies: complete revascularization including non-culprit lesions percutaneous coronary intervention(PCI) during primary PCI(PPCI) versus complete revascularisation during the same hospital admission in multi-vascular coronary artery disease(MVD) patients presenting with ST-elevation myocardial infarction(STEMI) uncomplicated by cardiogenic shock.
Study Overview
Detailed Description
Complete revascularisation in MVD patients with STEMI uncomplicated by cardiogenic shock has been shown to improve outcomes, however the optimal timing of treatment of the non-culprit lesions is not known.
The 2018 ESC/EACTS Guidelines on myocardial revascularization states that "routine revascularization of non-IRA (infarct related artery) lesions should be considered in patients with multivessel disease before hospital discharge".
Our trial showed that among the fore mentioned patients there was no difference regarding outcomes when using a strategy of complete revascularization with non-culprit lesions PCI during PPCI or during the same hospital admission.
Study Type
Observational
Enrollment (Actual)
100
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Bihor
-
Oradea, Bihor, Romania
- Spitalul Clinic Judetean de Urgenta Oradea
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 88 years (Adult, Older Adult)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
multivessel patients with STEMI uncomplicated by cardiogenic shock
Description
Inclusion Criteria:
- Men and women with successful PCI (preferably using a drug-eluting stent) to the culprit lesion for STEMI ( PCI for STEMI should be primary PCI in the first 12 hours after symptom onset) and complete revascularization of non-culprit lesions during the index PPCI procedure or during a different procedure performed before index hospital discharge.
Multi-vessel disease defined as at least 1 additional non-infarct related coronary artery lesion that is at least 2.5 mm in diameter that has not been stented as part of the primary PCI and that is amenable to successful treatment with PCI and has:
- At least 75% diameter stenosis (visual estimation) or
- At least 50% diameter stenosis (visual estimation) with fractional flow reserve (FFR) ≤ 0.80
- Age between 18 and 90 years
- Written informed consent could be obtained from all the patients
Exclusion Criteria:
- Rescue PCI for failed fibrinolysis or a combination strategy where PCI is performed routinely 3-12 hours after fibrinolysis
- Cardiogenic shock
- Non-cardiovascular known co-morbidity reducing life expectancy to < 2 years
- Any factor precluding 1year follow-up
- Prior Coronary Artery Bypass Graft (CABG) Surgery
- A different operator from the previously designated
- Unable to provide consent for any other reason
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
group A
patients who received complete revascularization by angioplasty during the PPCI
|
angioplasty of all non-culprit lesions
|
Group B
patients who underwent complete revascularization by angioplasty in a staged procedure
|
angioplasty of all non-culprit lesions
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
one year all-cause mortality
Time Frame: one year
|
death at one year
|
one year
|
MACCE at one year
Time Frame: one year
|
major adverse cardiac and cerebrovascular events including cardiac death, stroke, symptom-driven revascularization, myocardial infarction
|
one year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Mihnea-Traian T Nichita-Brendea, MD, Spitalul Clinic Judetean de Urgenta Oradea
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 1, 2020
Primary Completion (Actual)
September 1, 2020
Study Completion (Actual)
September 5, 2020
Study Registration Dates
First Submitted
October 4, 2020
First Submitted That Met QC Criteria
October 8, 2020
First Posted (Actual)
October 9, 2020
Study Record Updates
Last Update Posted (Actual)
October 9, 2020
Last Update Submitted That Met QC Criteria
October 8, 2020
Last Verified
October 1, 2020
More Information
Terms related to this study
Other Study ID Numbers
- Uoradea
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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