- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04726618
Development of Hardware and Software for Pulmonary Magnetic Resonance Imaging Using Inhaled Tracer Gases
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Respiratory diseases are a significant healthcare burden worldwide. In Canada, this is expected to increase. Non-invasive medical imaging tests are able to provide regional functional and structural information of the lung and may aid in the diagnosis and treatment of respiratory diseases. Current examples include chest x-ray, x-ray computed tomography (CT), and nuclear medicine techniques. However, these techniques suffer from various associated limitations. X-ray based methods offer high resolution and rapid acquisitions, but only reflect lung structure and anatomy by measuring tissue density. Nuclear medicine techniques may be used to measure lung function but suffer from poor resolution and long acquisition times. Furthermore, both x-ray based and nuclear medicine imaging techniques make use of ionizing radiation, which may not be suitable for longitudinal imaging, or imaging in vulnerable populations such as children.
Conventional Magnetic Resonance Imaging (MRI) images the 1H nucleus (proton) attached to water molecules in biological tissues. MRI can provide high-resolution anatomical and functional information of the lung with multiparametric contrast without the use of ionizing radiation. However, major drawbacks associated with conventional 1H MRI of the lung are the low tissue density, large magnetic susceptibility differences between numerous air/tissue interfaces, and image corruption by cardiorespiratory motion during the necessarily long image acquisition time frame. Wo;;
One strategy which may be employed to overcome the limitations associated with conventional 1H MRI is the application of safe MR-sensitive inhaled tracer gases. This allows for the direct visualization of the spatial distribution of these gases, revealing regional ventilation directly. In this study we aim to develop, implement, and test these technologies for improved in-vivo imaging of lung structure and function in adults and children with no history of respiratory disease.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Giles Santyr, PhD
- Phone Number: 301394 416-813-7654
- Email: giles.santyr@sickkids.ca
Study Contact Backup
- Name: Sharon Braganza, MSc
- Phone Number: 307937 416-813-7654
- Email: sharon.braganza@sickkids.ca
Study Locations
-
-
Ontario
-
Toronto, Ontario, Canada, M5G 0A4
- Recruiting
- Hospital for Sick Children
-
Contact:
- Giles Santyr, PhD
- Phone Number: 4168137654
- Email: giles.santyr@sickkids.ca
-
Contact:
- Sharon Braganza, MSc
- Phone Number: 307937 4168137654
- Email: sharon.braganza@sickkids.ca
-
Principal Investigator:
- Giles Santyr, PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Consent provided
- Aged 6-75 years old
- In good general health as evidenced by medical history
- Meets MRI screening criteria
Exclusion Criteria:
- Has diagnosis of pulmonary disease
- FEV1 <70%
- Requires supplemental oxygen
- Has had a respiratory infection within the past 2 weeks
- Pregnant or lactating*
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The primary objective of this study is to develop the necessary imaging sequences, reconstruction algorithms, and hardware to acquire high quality lung images using HP 129Xe, 19F MRI, and conventional 1H MRI.
Time Frame: 5 years
|
This objective will initially begin with preliminary work to demonstrate the ability to acquire in vivo 129Xe and/or 19F MR images in participants with no history of respiratory disease.
This study will also focus on the advancement of MR imaging hardware and software to optimize image acquisition and reconstruction.
Imaging capability will be evaluated on the basis of image quality, signal-to-noise ratio, contrast-to-noise ratio, image resolution, and scan duration.
We will also explore new methods of generating image contrast with these gases.
|
5 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Comparison of 19F MRI to HP 129Xe MRI
Time Frame: 5 years
|
19F MRI and HP 129Xe MRI are both inhaled tracer gases for MR imaging of lung function.
In this study we aim to demonstrate 19F imaging and compare image quality against HP 129Xe in adults and children.
|
5 years
|
Evaluation of intra and inter-scan reproducibility
Time Frame: 5 years
|
Repeat measurements will be performed within the study visit to evaluate intra-scan reproducibility.
Additionally, repeat measures will be performed in participants during subsequent visits on different days to quantify inter-scan repeatability of imaging measures developed in this study.
|
5 years
|
Comparison of MR imaging to pulmonary function testing
Time Frame: 5 years
|
The imaging measures developed in this study will be compared to pulmonary function tests which are considered the clinical gold standard for measuring lung function.
|
5 years
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Giles Santyr, PhD, The Hospital for Sick Children
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1000070140
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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