- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04764175
Telephone All Nations Breath of Life (tANBL)
Assessing Telephone All Nations Breath of Life for Efficacy
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The study uses a Bayesian Adaptive Design to examine efficacy of tANBL versus a non-tailored comparison program (CP). All participants will be offered individual telephone counseling, motivational text messaging, educational materials, and the choice of taking pharmacotherapy (must be obtained by participant). Participants in tANBL will receive the culturally tailored versions of all aspects of the program; participants in CP will receive non-tailored versions.
Telephone All Nations Breath of Life (tANBL) Intervention Components
Primary components of tANBL and modifications from the original program are described below:
Individual Sessions: The primary component of tANBL will be a series of individual support sessions, led by an AI facilitator. Community members will be trained in cessation support and counseling. All sessions begin with discussion of individual experiences. All facilitators can be given an extension on the study team's toll-free line, which can be used from any computer. Facilitators will track calls, who participates, how long they last, and recordings (for supervision and training). Facilitators will, in part, use Motivational Interviewing (MI), which has been found effective among AI, enhances motivation for change, and is based on the assumption that many with addictions are not ready to change. The goal is to increase motivation through discrepancy between current behavior and goals/values. The study team developed culturally sensitive counseling scripts to explore positive and negative aspects of, participants' motivation and confidence for quitting smoking, the pros and cons, and plans for change. Participants are asked to identify their values and explore connections between smoking and their ability to live out their values. Participants who score lower on motivation and confidence at each session will be given more Motivational Interviewing.
Text Messaging: Between phone calls, participants receive motivational culturally tailored text messaging, including messages about why smoking is detrimental to health, respecting the sacred nature of tobacco, simple motivational messages to continue trying to quit or stay quit, etc., based on the educational curriculum. The study team has a database of motivational messages developed during the pilot of tANBL; the team will develop and add more messages throughout program implementation to keep messaging relevant and fresh.
Educational Curriculum: The tANBL curriculum includes 11 brochures and combines the latest cessation methods with culturally specific elements, including substantial information about tobacco as a sacred plant for many, though not all, AI tribes, historical trauma, and medical/research mistrust issues, among other topics. Participants have stressed that cultural issues must be ingrained in the program, not given "lip service" with pictures of AI on otherwise "white" materials. Current materials were created by the study team, community advisors, partner organizations, and previous ANBL participants, then sent to an AI graphic artist for layout. Educational materials for this project will be given to participants in paper form based on preferences of pilot participants. Materials are available electronically if a participant wishes.
Pharmacotherapy: Current treatment guidelines suggest pharmacotherapy be offered to all smokers trying to quit; participants have choice of pharmacotherapy, including varenicline, bupropion, nicotine replacement therapy (NRT, patches, gum, or lozenges), a combination, or none, as current best practices suggest. The team considered providing pharmacotherapy as a part of the study, as investigators have done in some previous ANBL studies. However, after discussions with community partners (particularly tribal partners), the team learned that there was a preference for a more real-world scenario where participants can choose to purchase nicotine replacement therapy or see a personal physician for a prescription. Previous ANBL participants have also stated that they would have been able to obtain pharmacotherapy without the study and that provision of it was not a determining factor in taking it. After those discussions, investigators decided to not provide free pharmacotherapy to pilot tANBL participants. Participants were instead given the choice to purchase nicotine replacement therapy or obtain a prescription from personal physicians. Facilitators still discussed all of the available options and allowed participants to ask questions of both facilitators and the study physician to allow for an informed decision. Based on feedback from pilot participants, this was an appropriate approach and will be continued for the efficacy test of tANBL. Investigators will track use of the different types of pharmacotherapy and will examine how it affects quit rates. Facilitators will ask participants who choose not to use any pharmacotherapy about reasons for the choice.
Non-Tailored Comparison Program (CP) Intervention Components
To best test tANBL, we use similar components to the intervention for the CP:
Individual Telephone Sessions: CP arm participants will receive weekly phone calls from non-AI facilitators who will go over similar information using non-tailored materials from the American Cancer Society, through the web portal. Facilitators will not discuss traditional tobacco, historical trauma, or other AI specific topics. They will talk less about social support, as is more common in non-tailored programs.
Text Messaging: CP arm participants will receive non-tailored text messaging.
Educational Curriculum: Non-tailored educational brochures will be provided.
Pharmacotherapy: All participants will be provided with education about pharmacotherapy.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Christine M Daley, PhD, MA, SM
- Phone Number: 610-758-1878
- Email: cmdaley@lehigh.edu
Study Contact Backup
- Name: Luke Swimmer, MBA
- Phone Number: 610-758-1878
- Email: LSwimmer@lehigh.edu
Study Locations
-
-
Pennsylvania
-
Bethlehem, Pennsylvania, United States, 18015
- Recruiting
- Lehigh University
-
Contact:
- Luke Swimmer, MBA
- Phone Number: 610-758-1878
- Email: LSwimmer@lehigh.edu
-
Contact:
- Christine M Daley, PhD
- Phone Number: 610-758-1878
- Email: cmdaley@lehigh.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Age 18 or older
- Self-reported American Indian
- Smokes at least 1 cigarette per day
- Have a home address or stable address to which we can mail program supplies
- Have a stable telephone number that can be used for the purpose of the study
- Willing to be followed for 12 months
Exclusion Criteria:
- Cannot provide a stable phone number for the purpose of the study that will be available for a minimum of 12 months
- Household member already in the study
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Telephone All Nations Breath of Life
This is a culturally targeted smoking cessation program developed for American Indian communities.
It includes individual telephone counseling, text messaging, and educational materials.
|
Same as described above.
Other Names:
|
Active Comparator: Comparison Program
This is a non-culturally targeted smoking cessation program.
It includes individual counseling, text messaging, and educational materials.
|
Same as described above.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cessation
Time Frame: 6 months
|
7-day point prevalence abstinence from smoking cigarettes
|
6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cessation
Time Frame: 12 months
|
7-day point prevalence abstinence from smoking cigarettes
|
12 months
|
Continuous Cessation
Time Frame: 6 months, 12 months
|
Continuous abstinence from smoking cigarettes
|
6 months, 12 months
|
Smoking Change
Time Frame: 6 months, 12 months
|
Change in number of cigarettes per day
|
6 months, 12 months
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Christine M Daley, PhD, MA, SM, Lehigh University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 1612090-2
- R01DA048955 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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