- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04805320
Association of Periodontal Inflammation on Immune Response in Wound Healing
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Twenty-five healthy adult subjects (aged 21-70) requiring extraction of a posterior tooth will be recruited for this study. Prior to extraction, a limited-view cone beam computed tomography radiograph will be taken as well as clinical measures of periodontal inflammation (probing depths, recession, bleeding on probing, gingival crevicular fluid sampling). The extraction will be completed atraumatically and with local anesthesia. Following extraction, a small biopsy of the soft tissue of the extraction site will be taken and the site then sutured. At the two-week postoperative visit, sutures will be removed and another soft tissue biopsy of the healing site will be collected (along with clinical data from the adjacent teeth). The soft tissue biopsies will be fixed and processed for inflammatory endocytes present during wound healing. At the three-month postoperative visit, all clinical parameters of wound healing will be evaluated; including inflammatory measures (probing depths, recession, bleeding on probing, gingival crevicular fluid sampling) from the adjacent teeth; as well as a limited-view cone beam computed tomography radiograph.
The biopsies will be processed to obtain single cell counts with half of the preparation stained and analyzed via multiparameter flow cytometry. The other half of single cells obtained from the tissue biopsies will be cryopreserved for cellular indexing of transcriptomes and epitopes-sequencing.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Amy C Killeen, DDS
- Phone Number: 402-472-7848
- Email: akilleen@unmc.edu
Study Locations
-
-
Nebraska
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Lincoln, Nebraska, United States, 68583
- Recruiting
- University of Nebraska, College of Dentistry
-
Principal Investigator:
- Amy C Killeen, DDS, MS
-
Contact:
- Amy C Killeen, DDS, MS
- Phone Number: 402-472-7848
- Email: akilleen@unmc.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- non-restorable posterior tooth (molar/premolar) in need of extraction
Exclusion Criteria:
- systemic disease that effects inflammation
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Inflammatory cells
Time Frame: 3 months
|
Number of inflammatory cells present
|
3 months
|
Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Joseph B Bavitz, DMD, University of Nebraska, College of Dentistry
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 0257-21-FB
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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