- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04806152
Sarcopenia and Combined-modality Exercise
March 17, 2021 updated by: The University of The West Indies
Effect of Exercise on Muscle Mass, Functional Capacity and Physical Activity in Community-dwelling Elderly With Sarcopenia in Jamaica
This study examined the effects of combined-modality exercise training (resistance, endurance, flexibility and balance) on muscle mass, muscle function and physical activity in community-dwelling elderly living in Jamaica who had been characterised as having sarcopenia.
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Detailed Description
Community-dwelling seniors aged 60 years and older were screened for muscle mass and function (grip strength and walk speed) and persons with sarcopenia were identified using the European Working Group on Sarcopenia in Older Persons (EWGSOP) algorithm for case finding (N=1344).
Of the 77 seniors with sarcopenia, 38 consented to participate and were randomly allocated to receive 6 months combined-modality high intensity treadmill based exercise and a 'usual care' home exercise programme.
A comparison of the effects of treatment assignment on muscle mass, function, fitness, physical activity level and disability was done.
Participants in the supervised combined-modality high intensity group were required to attend sessions 3 times per week; participants in the home exercise programme were required to attend 1 supervised session at the start of their 6-month intervention.
Outcomes were assessed at baseline and at the end of the 6-month intervention.
Data were analysed using standard statistical parametric and non-parametric methods including repeated measures analysis of variance to determine changes in outcomes and regression to establish determinants of outcomes.
Study Type
Interventional
Enrollment (Actual)
38
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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KSA
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Kingston 7, KSA, Jamaica, JMAKN04
- UWI Solutions for Developing Countries (SODECO)
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
60 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- over 60 years old,
- independently ambulant, with or without an assistive device
- mentally competent to give informed consent and follow exercise instructions
Exclusion Criteria:
- a history of stroke with residual disability
- a diagnosis of cancer
- neuromuscular disorders
- auto-immune disorders
- dementia
- severe arthritis rendering participation in an exercise programme difficult
- unstable cardiovascular disease which renders exercise unsafe
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Factorial Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Sarcopenia and combined-modality high intensity supervised exercise training
Participants were given Treadmill exercise training, lower extremity progressive resistance training using a Cybex leg press machine, and a 1-hour adaptive physical activity (APA) programme in which participants were required to walk for 12 minutes through an obstacle course in which they must clear 10 cm high boards, climb 3 steps and walk sideways through hula-hoops placed on the floor all the while dual-tasking i.e. waving at strategically placed signs, conversing while walking and picking up objects.
Participants also performed exercises at the parallel bars which included weight-shifting from leg to leg and half-squatting; they were also guided through seated upper- and lower-limb stretching exercises for range of motion and trunk mobility.
All exercise sessions were supervised by physiotherapists.
For two of the weekdays on which participants did not attend supervised training, they were asked to walk for 30 minutes at home and perform the APA exercises described above.
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Supervised high-intensity combined-modality exercise was administered to participants in the exercise arm for 3 times per week for 6 months.
A post-exercise recovery protein drink (31g whey-based) was given within 15 minutes after each supervised exercise session.
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Active Comparator: Sarcopenia and 'usual care' unsupervised exercise
Participants were required to do 5-12 chair rises and also 30-minutes walking 5 days per week.
Upper limb and trunk flexibility exercises were also taught.
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Walking 30 minutes, chair rises and flexibility exercises for trunk and upper extremities 5 days per week
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Functional endurance
Time Frame: 6 months
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Distance walked in 6 minutes
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6 months
|
Disability
Time Frame: 6 months
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Lawton Instrumental Activities of Daily Living scale: minimum score = 0 (low function, dependent); maximum score = 8 (high function, independent).
Lower scores indicate a worse outcome.
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6 months
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Lower extremity (LE) functional strength
Time Frame: 6 months
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1-repetition maximum (RM) strength
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6 months
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Accelerometry
Time Frame: 6 months
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weekly energy expenditure
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6 months
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self-selected walk speed
Time Frame: 6 months
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speed in the timed-10-metre walk
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6 months
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Appendicular lean mass index
Time Frame: 6 months
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dual energy x-ray absorptiometry (DEXA) measured appendicular lean mass summed and divided by height squared, expressed in kg/m2
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6 months
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Balance
Time Frame: 6 months
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Berg balance test score: minimum score = 0, maximum score = 56.
Lower values indicate worse outcome
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6 months
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Fat-free mass
Time Frame: 6 months
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dual energy x-ray absorptiometry (DEXA) determined: fat mass subtracted from weight, expressed in kg
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6 months
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Depression
Time Frame: 6 months
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Center for Epidemiological Studies-Depression [CES-D] score: minimum score = 0, maximum score = 60, with higher scores indicating more depressive symptoms
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6 months
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Timed-up-and-go
Time Frame: 6 months
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Functional test indicating fall risk
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6 months
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Terrence Forrester, PhD, UWI Solutions for Developing Countries
- Principal Investigator: Michael Boyne, MD, UWI Department of Medicine
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 2, 2017
Primary Completion (Actual)
March 20, 2020
Study Completion (Actual)
March 20, 2020
Study Registration Dates
First Submitted
March 9, 2021
First Submitted That Met QC Criteria
March 17, 2021
First Posted (Actual)
March 19, 2021
Study Record Updates
Last Update Posted (Actual)
March 19, 2021
Last Update Submitted That Met QC Criteria
March 17, 2021
Last Verified
March 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- UWIJAMSarc
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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