- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04810312
Combined Exercise and Nutrition Intervention for Spinal Sarcopenia
Combined Exercise and Nutrition Intervention for Spinal Sarcopenia: a Pilot Study
Sarcopenia in the lumbar paraspinal muscles is receiving renewed attention as a cause of spinal degeneration. However, there were few studies on the precise concept and diagnostic criteria for spinal sarcopenia. We have already developed the concept of spinal sarcopenia in community-dwelling older adults and investigated the association between conventional sarcopenic indices and spinal sarcopenia. However, intervention studies on spinal sarcopenia have not been conducted until now. Here, we aim a pilot study to evaluate the effectiveness of the combined exercise and nutrition intervention for spinal sarcopenia.
This is a prospective study with 35 community-dwelling older women who were diagnosed as spinal sarcopenia in our previous cohort study. Combined intervention will consist of back extensor strengthening exercise and nutritional supplementation for 12 weeks. The primary outcome of this study is isometric back extensor strength after 12 weeks' intervention. All functional outcomes will be measured at 0, 12, and 24 weeks after intervention. The data will be analysed using the intention-to-treat principle.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: SANG YOON LEE, MD, PhD
- Phone Number: +82-2-870-2673
- Email: rehabilee@gmail.com
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Older women (≥ 65 years old)
- Community-dwellers
- Able to walk with or without assistive devices for more than 100 meters
Exclusion Criteria:
- Low back pain with moderate severity (numeric rating scale 5 and over)
- History of any types of lumbar spine surgery
- History of hip fracture surgery and arthroplasty of hip or knee
- Contraindications for MRI (such as cardiac pacemaker, implanted metallic objects, and claustrophobia)
- Disorders in central nervous system (such as stroke, parkinsonism, spinal cord injury)
- Cognitive dysfunction (Mini Mental State Examination score < 24)
- Communication disorder (such as severe hearing loss)
- Musculoskeletal condition affecting physical function (such as amputation of limb)
- Long-term use of corticosteroids due to inflammatory disease
- Malignancy requiring treatment within 5 years
- Other medical conditions which need active treatment
- Subjects who refuse to participate in a study
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Intervention group
Back extensor strengthening with oral protein supplementation
|
Back extensor strengthening exercise and nutritional supplementation for 12 weeks
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Isometric back extensor strength
Time Frame: 12 weeks after intervention
|
Isometric back muscle strength test using a handheld dynamometer (PowerTrack II; JTECH Medical, Salt Lake City, UT, USA)
|
12 weeks after intervention
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Isometric back extensor strength
Time Frame: 24 weeks after intervention
|
Isometric back muscle strength test using a handheld dynamometer Shirley, NY, USA) to measure the torque of the back extensors
|
24 weeks after intervention
|
Isokinetic back extensor strength
Time Frame: 12 weeks after intervention
|
Isokinetic dynamometer (Biodex multi-joint system, Biodex Corporation, Shirley, NY, USA) to measure the torque of the back extensors
|
12 weeks after intervention
|
Isokinetic back extensor strength
Time Frame: 24 weeks after intervention
|
Isokinetic dynamometer (Biodex multi-joint system, Biodex Corporation, Shirley, NY, USA) to measure the torque of the back extensors
|
24 weeks after intervention
|
Lumbar paraspinal muscle volume
Time Frame: 12 weeks after intervention
|
Lumbar spine MRI will be performed using a 1.5-T scanner (Achieva 1.5 T; Philips Healthcare, Netherlands)
|
12 weeks after intervention
|
Short physical performance battery (SPPB)
Time Frame: 12 weeks after intervention
|
Physical performance test (0-12)
|
12 weeks after intervention
|
Short physical performance battery (SPPB)
Time Frame: 24 weeks after intervention
|
Physical performance test (0-12)
|
24 weeks after intervention
|
Spinal sagittal balance parameters
Time Frame: 12 weeks after intervention
|
Sagittal vertical axis (SVA) distance (mm)
|
12 weeks after intervention
|
Spinal sagittal balance parameters
Time Frame: 24 weeks after intervention
|
Sagittal vertical axis (SVA) distance (mm)
|
24 weeks after intervention
|
Collaborators and Investigators
Investigators
- Principal Investigator: SANG YOON LEE, MD, PhD, SMG-SNU Boramae Medical Center
Study record dates
Study Major Dates
Study Start (ANTICIPATED)
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 10-2021-27
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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