Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy

Impact of High-Intensity Interval Training on Insulin Resistance During Pregnancy: A Randomized Control Trial.

Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of adverse health problems, including coronary heart disease, type 2 diabetes, breast and colon cancers. It also shortens life expectancy. Pregnancy is a period in the life of women that is often associated with decreased daily physical activity and decreased participation in sports and exercise . In the first few weeks of pregnancy, maternal carbohydrate metabolism is affected by a rise in maternal levels of estrogen and progesterone that stimulates pancreatic β-cell hyperplasia and insulin secretion. As pregnancy progress, pancreatic islet cell hypertrophy continues and there is an increased insulin response to glucose or meal stimulation.

Study Overview

• Status: Completed
• Conditions: High Intensity Interval Training; Diet, Healthy
• Intervention / Treatment: Dietary supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks

Detailed Description

This study was carried out upon twenty multigravida pregnant female between 5-6 months gestation with IR calculated by HOMA test (fasting blood glucose× fasting insulin) ÷ 22.5. Fasting blood glucose was assessed by the method approved by (7, 13) .The test materials for this method were supplied as kits by "Diamond Diagnostics," while Insulin concentrations were stated in formerly frozen and defrosted serum samples by enzyme immunoassay using the human Insulin ELISA kits.

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Egypt
  • Giza, Egypt, 12613
    • Ghada Elrefaye

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 25 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• forty multigravida females.
• their age ranged between 25 to 35 years old.
• Body mass index (BMI) <30kg/ m².

Exclusion Criteria:

• females with pelvic pathology as endometriosis.
• females have irregular menstrual cycles.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: diet program; moderate restricted diet (1800-2000 kcal/day) for four weeks, 3 sessions weekly	Dietary supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks; high intensity interval training 3 sessions for four weeks; Other Names: high intensity interval training
Experimental: high intensity interval training; high intensity interval training for four weeks, 3 sessions weekly	Dietary supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks; high intensity interval training 3 sessions for four weeks; Other Names: high intensity interval training

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Fasting blood glucose level	Fasting blood glucose level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.	three months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Fasting Insulin Level	Fasting blood insulin level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.	three months

Collaborators and Investigators

• Sponsor: Cairo University
• Collaborators: Heba mohamed Embaby; Salwa Elgendy

Study record dates

Study Major Dates

• Study Start (Actual): March 24, 2020
• Primary Completion (Actual): October 30, 2020
• Study Completion (Actual): November 1, 2020

Study Registration Dates

• First Submitted: April 1, 2021
• First Submitted That Met QC Criteria: April 1, 2021
• First Posted (Actual): April 5, 2021

Study Record Updates

• Last Update Posted (Estimate): January 19, 2023
• Last Update Submitted That Met QC Criteria: January 18, 2023
• Last Verified: January 1, 2023

More Information

Terms related to this study

• Keywords: Training; Pregnancy; Insulin Resistance
• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Hyperinsulinism; Insulin Resistance
• Other Study ID Numbers: Cairo Un100

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No