- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04855799
GI Permeability Change in Response to Aquamin®
Direct Measurement of Gastrointestinal Permeability Change in Response to Aquamin®
Study Overview
Status
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Estimated)
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Muhammad Nadeem Aslam
- Phone Number: 734-936-1897
- Email: mnaslam@umich.edu
Study Locations
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48109
- Recruiting
- University of Michigan Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria for UC participants:
- Must be able to give written informed consent
- Age 18 to 80 years old.
- Must have: Ulcerative colitis with confirmed diagnosis by histology and endoscopy; and be in stable remission for 3 months or more without therapy or with maintenance therapy (except steroids and antibiotics for 3 months) or have mild ulcerative colitis. Note: Corticosteroids (a type of steroid drug such as prednisone or cortisol that helps the body to regulate stress response, immune response and inflammation) and antibiotics can be used during a flare-up once the study has begun and the subject enrolled.
- A negative pregnancy test for pre-menopausal women with intact female reproductive organs. Must agree to use appropriate birth control over the study period (if applicable).
If cessation of menses is within 12 months, then the participant will be treated as pre-menopausal and a pregnancy test will be performed.
Inclusion Criteria for Healthy participants:
- Must be able to give written informed consent
- Be generally healthy, male or female, ages 18 to 80 years old.
- Pre-menopausal women with intact female reproductive organs must have a negative pregnancy test within 2 weeks of the Baseline Visit.
- Subject must agree to use appropriate birth control over the study period. (Post-menopausal is defined as no menses for the previous 12 months. If cessation of menses is within 12 months, then the participant will be treated as pre-menopausal and a pregnancy test will be performed.
Inclusion Criteria for participants with IBS-D:
- Patients with ages 18-80 years old.
- Must meet the IBS-D Diagnostic Rome IV (four) Criteria as noted in the protocol
- A negative pregnancy test for pre-menopausal cis-women with intact vagina, uterus, and/or ovaries. The negative pregnancy test must be within 2 weeks of the baseline visit and the subject must agree to use appropriate birth control over the study period.
Exclusion Criteria For UC participants:
- Must not be pregnant or lactating
- Must not be participating in any other interventional trial using an investigational drug.
- Subjects likely to be uncooperative or unable to comply with study procedures
- Participants must not be felt to have active ulcerative colitis for 3 months before study enrollment (with an exception of mild ulcerative colitis).
- Participants must not have a history or diagnosis of any of the following conditions:
Crohn's disease, Any stomach or intestinal bleeding disorders (gastrointestinal bleeding from gastric or duodenal ulcers, or gastrin secreting tumors) or active gastric/duodenal ulcers - peptic ulcer disease (without bleeding in last 3 months).
- Must not have any gastrointestinal or colonic malignancy.
- Must not have Kidney disease, including kidney "stones" or hypercalcemia.
- Must not have Coagulopathy/hereditary hemorrhagic disorders
- Participants will be excluded if they have taken certain medications (per protocol), within the last 30 days or are unwilling to forgo the following for 30 days prior to entry into the study.
Exclusion Criteria For Healthy participants:
- Must not be pregnant or lactating.
- Must not be participating in any other interventional trial using an investigational drug.
- Participants must not have a history or diagnosis of any of the following conditions:
Kidney disease, including kidney "stones" or hypercalcemia, Crohn's disease, Neurologic disease, other inflammatory bowel disease, any stomach or intestinal bleeding disorders (gastrointestinal bleeding from gastric or duodenal ulcers, or gastrin secreting tumors) or active gastric/duodenal ulcers - peptic ulcer disease (without bleeding in last 3 months).
- Not have Coagulopathy/hereditary hemorrhagic disorders
- Any gastrointestinal or colonic malignancy.
- Participants will be excluded if they have taken certain medications (per protocol), within the last 30 days or are unwilling to forgo the following for 30 days prior to entry into the study.
Exclusion Criteria for participants with IBS-D:
- Must not be pregnant or lactating
- Must not be participating in any other interventional trial using an investigational drug.
- Participants must not have a history or diagnosis of Crohn's disease or Inflammatory bowel disease, any stomach or intestinal bleeding disorders (gastrointestinal bleeding from gastric or duodenal ulcers, or gastrin secreting tumors) or active gastric / duodenal ulcers - peptic ulcer disease (without bleeding in last 3 months).
- Must not have any gastrointestinal or colonic malignancy.
- Must not have kidney disease, including kidney "stones" or hypercalcemia, Coagulopathy/hereditary hemorrhagic disorders, neurologic disease
- Participants will be excluded if they have taken certain medications (per protocol), within the last 30 days or are unwilling to forgo the following for 30 days prior to entry into the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Aquamin®
|
Participants will take a 90-day supply of Aquamin®, 4 capsules per day; 2 to be taken in the morning and 2 in the evening (containing approximately 800 mg calcium/day).
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change in the lactulose:mannitol ratio in urine by comparing values at 90-days (post-intervention) to baseline (pre-intervention) levels.
Time Frame: Baseline (pre-intervention), 90 days (post-intervention)
|
Baseline (pre-intervention), 90 days (post-intervention)
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: James Varani, University of Michigan
- Study Director: Muhammad N Aslam, University of Michigan
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- HUM00156676 sub-study 1
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Healthy
-
Prevent Age Resort "Pervaya Liniya"RecruitingHealthy Aging | Healthy Diet | Healthy LifestyleRussian Federation
-
Maastricht University Medical CenterCompletedHealthy Volunteers | Healthy Subjects | Healthy AdultsNetherlands
-
Yale UniversityNot yet recruitingHealth-related Benefits of Introducing Table Olives Into the Diet of Young Adults: Olives For HealthHealthy Diet | Healthy Lifestyle | Healthy Nutrition | CholesterolUnited States
-
Hasselt UniversityRecruitingHealthy | Healthy AgingBelgium
-
Galera Therapeutics, Inc.Syneos HealthCompleted
-
Galera Therapeutics, Inc.Syneos HealthCompletedHealthy | Healthy VolunteersAustralia
-
University of PennsylvaniaActive, not recruitingHealthy | Healthy AgingUnited States
-
Chalmers University of TechnologyGöteborg UniversityCompletedHealthy | Nutrition, HealthySweden
-
University of ManitobaNot yet recruitingHealthy | Healthy Diet
Clinical Trials on Aquamin
-
University College CorkUnknown
-
Marigot Ltd.CompletedOsteoarthritis of the KneeUnited States
-
James VaraniRecruiting
-
Marigot Ltd.CompletedOsteoarthritis of the Knee
-
University of MichiganRecruiting
-
University College DublinMarigot Ltd.UnknownKnee OsteoarthritisIreland
-
University College DublinUnknownLactate Blood Increase | Exercise-Induced Lactic Acidemia