Epidemiological Study on the Management of Out-of-hospital Cardiac Arrest Survivors in Champagne ArDEnnes (CASCADE)

Out-of-hospital cardiac arrest (OHCA) is a public health problem, affecting 50,000 people per year in France. Intervention time (initiation of cardiopulmonary resuscitation (CPR) and advanced CPR) are associated with a better prognosis. Despite this, the latest published data show a very low overall survival (5%). Our territory has only three centers distributed hospitals with both a 24-hour coronary angiography platform and an intensive care unit. Finally, although 60% of ACEHs receive coronary angiography in the Île de France region, it is performed on only 15% of patients in the Reims University Hospital.

Therefore, it seems essential to conduct a study on the reality of the support of ACEH and to study the clinical and biological factors as well as the influence of the geographical distribution of specialized technical platforms on the prognosis of patients.

Study Overview

• Status: Recruiting
• Conditions: Out-of-hospital Cardiac Arrest
• Intervention / Treatment: Other: observational

• Study Type: Observational
• Enrollment (Anticipated): 294

Contacts and Locations

• Study Contact: Name: Stéphane Sanchez, MD; Phone Number: +33625036892; Email: stephane.sanchez@hcs-sante.fr

Study Locations

• France
  • Champagne Ardennes
    • Troyes, Champagne Ardennes, France, 10000
      • Recruiting
      • hospital center of Troyes
      • Contact: Stéphane SANCHEZ

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Our participants must be the victim of an ACEH on the Champagne-Ardenne territory admitted living in the hospital and be over eighteen years old

Description

Inclusion Criteria:

• Patient victim of ACEH in the Champagne-Ardenne region admitted living in hospital.

Exclusion Criteria:

• patient under the age of 18

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Cohort; Patient present in the SAU after an extra-hospital cardiac arrest	Other: observational; Collect from a bank of biological samples, identification of prognostic factors associated with survival without serious neurological heavy sequelae

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Analysis of prognostic factors associated with survival without severe neurological sequelae (CPC 1-2) at 3 months among the following variables	3 months
Analysis of prognostic factors associated with survival without severe neurological sequelae (CPC 1-2) with collection of a bank of biological samples, identification of clinical factors and targeted temperature control	12 months

Collaborators and Investigators

• Sponsor: Stephane Sanchez

Study record dates

Study Major Dates

• Study Start (ACTUAL): October 4, 2021
• Primary Completion (ANTICIPATED): December 31, 2023
• Study Completion (ANTICIPATED): December 31, 2023

Study Registration Dates

• First Submitted: June 18, 2021
• First Submitted That Met QC Criteria: August 3, 2021
• First Posted (ACTUAL): August 6, 2021

Study Record Updates

• Last Update Posted (ACTUAL): August 1, 2022
• Last Update Submitted That Met QC Criteria: July 29, 2022
• Last Verified: July 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Heart Arrest; Out-of-Hospital Cardiac Arrest
• Other Study ID Numbers: The CASCADE Study

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No