- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05024136
Study on the Efficacy of Vetiver Essential Oil Aroma on Depression/Anxiety People
June 20, 2022 updated by: You-Cheng Shen, Chung Shan Medical University
In this study, subjects with depression/anxiety inhaled the essential oil, which contained sedative, soothing, and relaxing active ingredients to stimulate the olfactory nerve.
The essential oil further transmitted to the limbic system that controls emotions in the brain, and then affected the human's mood.
The natural aroma can not only awaken the limbic system's memory of aroma but also reflect the subconscious area of the brain, with physiological changes (such as controlling blood pressure, breathing, heartbeat, stress changes, memory, and hormonal coordination.)
This study monitors the subject's autonomic nerve parameters before and after aromatherapy to obtain the olfactory cerebral nervous system to convey the message.
When the study finishes, we expected to help the subject to relax and soothe the mind.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
Subjects receive three times 30 mins aromatherapy of Limon or Vetiver essential oil per time for the month.
Anthropometric measurements such as blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b.
HRV(heart rate variability); c.
LF(0.04-0.15
Hz)and HF(0.15-0.4
Hz)were measured every week.
PSQI(Pittsburgh sleep quality index)and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.
Study Type
Interventional
Enrollment (Anticipated)
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: You-Cheng Mr Shen, Ph.D.
- Phone Number: 12107 886-4-24730022
- Email: youcheng@csmu.edu.tw
Study Contact Backup
- Name: Chang-Yao Mr TSAO, MD/PhD.
- Phone Number: 21735 886-4-24739595
- Email: irb@csh.org.tw
Study Locations
-
-
-
Taichung, Taiwan
- Recruiting
- Chung Shan Medical University
-
Contact:
- You-Cheng Mr Shen, Ph.D.
- Phone Number: 12107 886-4-24730022
- Email: youcheng@csmu.edu.tw
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 63 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Depressed/anxious people (diagnosed as a single episode of major depression, recurrence of major depression, mild depression, panic disorder, and anxiety.) Those diagnosed with symptoms of depression, and anxiety related to stress adjustment disorder, and willing to cooperate with the study.
- Age 20-65 years old
Exclusion Criteria:
- an alcoholic
- Uncontrolled diabetes
- Those who have had a stroke in the last year
- Pregnant and lactating women
- People with liver or heart disease
- Arrhythmia or those with a heart rhythm regulator
- Those whose heart has already been fitted with a cardiac catheter stent
- Those who have used central nervous system stimulants (regardless of the length of time)
- Those who are allergic to essential oils
- Those who have used aromatherapy within a month
- Subjects request to withdraw from the trial
- The host feels unsuitable to continue the study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Placebo
Subjects take 30 mins aromatherapy of Limon essential oil per time, a total of 3 times for the month.
|
Subjects receive three times 30 mins aromatherapy of Limon essential oil per time for the month.
Anthropometric measurements such as blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b.
HRV(heart rate variability); c.
LF(0.04-0.15
Hz)and HF(0.15-0.4
Hz)were measured every week.
PSQI(Pittsburgh sleep quality index)and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.
|
Experimental: Experimental
Subjects take 30 mins aromatherapy of vetiver essential oil per time, a total of 3 times for the month.
|
Subjects receive three times 30 mins aromatherapy of vetiver essential oil per time for the month.
Anthropometric measurements such as blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b.
HRV(heart rate variability); c.
LF(0.04-0.15
Hz)and HF(0.15-0.4
Hz)were measured every week.
PSQI(Pittsburgh sleep quality index)and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The aromatherapy measure autonomic nerve parameter SDNN (standard deviation of all normal to normal intervals index)
Time Frame: one month
|
one month
|
|
The measure blood pressure (SBP and DBP)
Time Frame: one month
|
values change of systolic and diastolic BPs
|
one month
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 20, 2021
Primary Completion (Anticipated)
October 1, 2022
Study Completion (Anticipated)
March 1, 2023
Study Registration Dates
First Submitted
May 20, 2021
First Submitted That Met QC Criteria
August 26, 2021
First Posted (Actual)
August 27, 2021
Study Record Updates
Last Update Posted (Actual)
June 22, 2022
Last Update Submitted That Met QC Criteria
June 20, 2022
Last Verified
June 1, 2022
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CS1-20030
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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