- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05076123
Efficacy of Modified Constraint Induced Movement Therapy Combined With Threshold Electrical Stimulation in Stroke Patients
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Istanbul, Turkey, 34000
- Emel Mete
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Stroke patients aged between 18-80 years
- Having had a stroke at least 3 months and at most 24 months ago
- Having an active range of motion of the upper extremity which is stated below:
Shoulder flexion and abduction of at least 45 degrees Starting from a 90° flexion position, at least 20° elbow extension Starting from full of wrist flexion position at least 20° wrist extension At least 10° of extension at the metacarpophalangeal and interphalangeal joints of all fingers
- Absence of severe spasticity to affect the treatment (spasticity in any joint of the upper extremity ≤2 according to the Modified Ashworth Scale)
Exclusion Criteria:
- Uncontrollable arrhythmia and/or hypertension
- Presence of advanced sensory deficit
- Visual and hearing problems
- Presence of severe spasticity to affect the treatment (spasticity in any joint of the upper extremity >2 according to the Modified Ashworth Scale)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Experimental group-1 (M-CIMT group)
participants in this group will be trained with Modified Constraint Induced Therapy (M-CIMT) in addition to conventional therapy.
M-CIMT is shorter versions of CIMT.
The original CIMT devotes six or more hours for therapy and constraining of the intact arm for 90% of waking hours per day and over a period of two weeks.
Researchers have observed that such a schedule of CIMT is exhaustive and possibly resulting in non-compliance.
Because of this reason,s Modified shorter versions of CIMT (mCIMT) have been designed by researchers.
Duration of M-CIMT interventions varies from 2 to 10 weeks and the treatment time also varies from as short as 30 minutes to three hours per day in various studies.
Nevertheless both CIMT and mCIMT have shown promising success.
M-CIMT emphasizes massed practice with the affected upper limb.
|
M-CIMT emphasizes massed practice with the affected upper limb with restraining unaffected limb by a mitt.
Threshold electrical stimulation is based on low-intensity (<100 Hz) and long-duration current and is applied with superficial electrodes.
|
Experimental: Experimental group-2 (M-CIMT+TES group)
participants in this group will be trained with Modified Constraint Induced Therapy (M-CIMT) and threshold electrical stimulation (TES) in addition to conventional therapy.
TES is based on low-intensity (<100 Hz) and long-duration current and is applied with superficial electrodes.
TES provides a natural proprioception by depolarizing the sensory and motor nerves without causing any muscle contraction.
TES can improve motor learning and motor performance by improving connections between sensory-motor cortical association regions in the brain.
|
M-CIMT emphasizes massed practice with the affected upper limb with restraining unaffected limb by a mitt.
Threshold electrical stimulation is based on low-intensity (<100 Hz) and long-duration current and is applied with superficial electrodes.
|
No Intervention: Control group
participants in this group will be trained with conventional therapy.
Conventional therapy consists of strength training, stretching exercises and functional activity training.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Range of motion (ROM) of upper extremity
Time Frame: Change from baseline Range of Motion (ROM) at week 4.
|
A universal goniometer will be used to evaluate ROM (shoulder flexion and abduction, elbow flexion and extension, wrist flexion and extension and extension of fingers).
Kendall-McCreary criteria will be considered in the assessments.
Measurements will be repeated three times and the average value will be used in the statistical analysis.
|
Change from baseline Range of Motion (ROM) at week 4.
|
Pain of upper extremity
Time Frame: Change from baseline pain at week 4.
|
Pain (pain of shoulder, elbow, wrist and fingers) will be evaulated with VAS (Visual Analog Scale).
The VAS consists of a 10 cm straight line which presents a continuum of intensity and has verbal anchors at opposite ends representing 'no pain' at the bottom and 'pain as bad as it can be' at the top.
The participants will be asked to mark the representing point of their pain levels.
The values will be recorded in centimeters.
|
Change from baseline pain at week 4.
|
Muscle tone and viscoelastic properties of muscle:
Time Frame: Change from baseline muscle tone at week 4.
|
Muscle tone will be evaluated with the Myoton®PRO Digital Palpation Device.
It is an evidence-based Class 1 device that evaluates the bio-mechanical properties of soft biological tissues in a non-invasive, objective, reliable, inexpensive, quick and easy way.
Myoton® PRO is used in research to evaluate superficial skeletal muscles, connective tissues such as tendons and ligaments, and other soft tissues
|
Change from baseline muscle tone at week 4.
|
Severity of spasticity
Time Frame: Change from baseline severity of spasticity at week 4.
|
The Modified Tardieu scale will be used to assess the severity of spasticity.
In this method, the severity of spasticity is evaluated at different rates determined.
At the joint, the first angle at which the increase in resistance is detected is recorded.
The range of motion is compared to the angle at completion.
The Stretching Velocities are as follows: V1: As slow as possible (slower than the gravity fall speed of the limb segment) V2: At the rate of gravity fall of the limb V3: As fast as possible (faster than the normal gravity fall speed of the limb).
|
Change from baseline severity of spasticity at week 4.
|
Superficial sensory function
Time Frame: Change from baseline superficial sense of upper extremity at week 4.
|
The Semmes Weinstein monofilament test battery will be used to evaluate the superficial sense of upper extremity.
Monofilaments of varying thickness between 1.65 and 6.65 are used in this test battery.
The evaluator applies in order from the smallest filament to the largest filament, the test is stopped when the monofilament is detected by the evaluator.
It is a reliable method used in the superficial sensory evaluation of stroke patients.
|
Change from baseline superficial sense of upper extremity at week 4.
|
Health-Related Quality Of Life
Time Frame: Change from baseline quality of life at week 4.
|
"Stroke-specific quality of life scale (SSQOL)" will be used to evaluate quality of life.
SSQOL; It is a valid and reliable scale consisting of 12 subsections, including energy, family roles, language, mobility, mood, personality, self-care, social roles, thinking, upper extremity function, vision and productivity, and a total of 49 questions.
It is graded with Likert-type scoring ranging from 1 to 5.
|
Change from baseline quality of life at week 4.
|
Functional Status
Time Frame: Change from baseline functional status at week 4.
|
Wolf Motor Function test is used to evaluate upper extremity motor functions.
For 15 activities, data is collected in 2 areas, "Functional Skill" and "Performance Time".
Using the "Functional Skills Scale", each activity is evaluated between 0-5 points (0= Never used the affected hand during the activity, 5= Normal movement).
The average score is calculated for the Functional Skill Scale.
Performance Time" is recorded in seconds (sec).
|
Change from baseline functional status at week 4.
|
Motor activity
Time Frame: change from baseline motor actvity at week 4.
|
Motor activity diary-28 (MAG-28) will be used to evaluate motor activity.
The MAG-28 is a valid and reliable scale designed to examine how often and how well a person uses their affected arm outside of the treatment session.
It consists of two scales that question how often the patient uses the affected side upper extremity for each activity during daily activities (turning the light switch, opening the door, etc.) (Use Frequency Scale), and if so, how well he or she can perform the activity (Movement Quality Scale).
The patient scores himself between 0 and 5 (0 = I do not use my affected arm at all, 5 = I use my affected arm with the same frequency/quality as before the stroke).
For the average score, the total scores of both scales are calculated separately and divided by the number of questions
|
change from baseline motor actvity at week 4.
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- doctoral thesis
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Stroke
-
University Hospital, GhentRecruitingStroke | Stroke, Ischemic | Stroke, Acute | Stroke Sequelae | Stroke HemorrhagicBelgium
-
Moleac Pte Ltd.RecruitingStroke | Stroke, Ischemic | Stroke Sequelae | Stroke, Cardiovascular | Strokes Thrombotic | Stroke, Embolic | Stroke, CryptogenicSingapore, Philippines
-
Moleac Pte Ltd.Not yet recruitingStroke | Stroke, Ischemic | Stroke Sequelae | Stroke, Cardiovascular | Strokes Thrombotic | Stroke, Embolic | Stroke, Cryptogenic
-
University of Illinois at ChicagoRecruitingStroke, Ischemic | Stroke Hemorrhagic | Stroke, CerebrovascularUnited States
-
IRCCS San Camillo, Venezia, ItalyRecruitingStroke | Stroke, Ischemic | Stroke Sequelae | Stroke HemorrhagicItaly
-
Vanderbilt University Medical CenterPatient-Centered Outcomes Research Institute; University of Alabama at BirminghamEnrolling by invitationStroke | Stroke, Ischemic | Stroke, Acute | Stroke Sequelae | Engagement, Patient | Stroke HemorrhagicUnited States
-
University of MinnesotaAmerican Occupational Therapy FoundationRecruitingStroke | Stroke Sequelae | Stroke Hemorrhagic | Stroke IschemicUnited States
-
University of British ColumbiaCanadian Institutes of Health Research (CIHR); Michael Smith Foundation for...RecruitingStroke | Stroke, Ischemic | Stroke Hemorrhagic | Chronic StrokeCanada
-
University of CincinnatiMedical University of South Carolina; University of California, Los Angeles; University...RecruitingStroke | Stroke, Ischemic | Stroke, Acute | Stroke HemorrhagicUnited States
-
University of LiegeCompletedStroke, Acute | Stroke Hemorrhagic | Stroke, ComplicationBelgium
Clinical Trials on Modified Constraint Induced Therapy and Threshold Electrical Stimulation
-
Riphah International UniversityNot yet recruiting
-
Assistance Publique - Hôpitaux de ParisTerminated
-
Abant Izzet Baysal UniversityCompletedSpastic Hemiplegic Cerebral PalsyTurkey
-
University Hospital of North NorwayHelse NordTerminated
-
Kathy GrindeCompletedCerebral Palsy | Hemiplegia | Unilateral Cerebral PalsyUnited States
-
Chang Gung Memorial HospitalCompletedCerebral Palsy | Brain Damage | Traumatic Brain DamageTaiwan
-
University of Missouri-ColumbiaWashington University School of Medicine; Christine M. Kleinert Institute for...RecruitingPeripheral Nerve Injuries | Hand Transplantation | Neurologic RehabilitationUnited States
-
University of PennsylvaniaRecruitingPrimary Progressive AphasiaUnited States
-
Istanbul UniversityUnknownStroke PatientsTurkey
-
Universita di VeronaCompleted