- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05194930
Treatments for Insomnia in Veterans With PTSD
A Novel Acceptance-based Treatment for Insomnia in Veterans With Post-Traumatic Stress Disorder
This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral components of CBT-I with components of another behavioral therapy (Acceptance and Commitment Therapy) and has been shown to improve treatment adherence.
The study objectives are: 1) to evaluate the benefits of ABC-I in reducing post-traumatic stress disorder (PTSD) symptoms among Veterans with comorbid PTSD and insomnia disorder compared to CBT-I, and 2) to evaluate the effectiveness of ABC-I in improving insomnia symptoms and sleep quality among Veterans with comorbid PTSD and insomnia disorder as compared to CBT-I.
Veterans with insomnia and comorbid PTSD who receive care at Sepulveda and West Los Angeles facilities will be recruited for the study. Those who pass an initial eligibility screen will be enrolled and written informed consent will be obtained. A baseline assessment will be completed that includes measures of sleep, PTSD, and quality of life. Veterans who meet all eligibility criteria will be randomly assigned to the ABC-I (n=100) or CBT-I (n=100) treatment. Both treatments will be provided in 5 one-on-one sessions by a trained instructor who is supervised by a behavioral sleep medicine specialist. All randomized participants (n=200) will have 3 follow-up assessments (post-treatment, 3-months, and 6-months after randomization). The follow-up assessments will collect information on PTSD symptoms, insomnia symptoms and sleep quality.
Study Overview
Status
Detailed Description
Poor sleep is a nearly universal experience after trauma and in the context of PTSD non-pharmacological therapies are considered first-line treatments, yet VA/DoD clinical practice guidelines acknowledged the paucity of available evidence on the treatment of insomnia disorder in the context of PTSD. There is evidence of sleep-related benefits with CBT-I for individuals with insomnia and psychiatric comorbidities, but challenges remain. Insomnia treatments studied among Veterans with PTSD have typically been combined treatments to address both conditions. While promising, these treatments are difficult to implement because of their length and complexity. Furthermore, studies generally have not compared novel sleep-focused treatments to CBT-I (i.e., standard care for insomnia), making it difficult to support a change in the allocation of clinical resources to train providers in new sleep-focused interventions.
This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral components of CBT-I with components of another behavioral therapy (Acceptance and Commitment Therapy) and has been shown to improve treatment adherence.
The study objectives are: 1) to evaluate the benefits of ABC-I in reducing PTSD symptoms among Veterans with comorbid PTSD and insomnia disorder compared to CBT-I, and 2) to evaluate the effectiveness of ABC-I in improving insomnia symptoms and sleep quality among Veterans with comorbid PTSD and insomnia disorder as compared to CBT-I.
Veterans with insomnia and comorbid PTSD who receive care at Sepulveda and West Los Angeles facilities will be recruited for the study. Those who pass an initial eligibility screen will be enrolled and written informed consent will be obtained. A baseline assessment will be completed that includes measures of sleep, PTSD, and quality of life. Veterans who meet all eligibility criteria will be randomly assigned to the ABC-I (n=100) or CBT-I (n=100) treatment. Both treatments will be provided in 5 one-on-one sessions by a trained instructor who is supervised by a behavioral sleep medicine specialist. All randomized participants (n=200) will have 3 follow-up assessments (post-treatment, 3-months, and 6-months after randomization). The follow-up assessments will collect information on PTSD symptoms, insomnia symptoms and sleep quality. The analytic plan will simultaneously address superiority of ABC-I over CBT-I for improving PTSD symptoms and non-inferiority of ABC-I compared to CBT-I for improving insomnia symptoms.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Jennifer L Martin, PhD
- Phone Number: 36080 (818) 891-7711
- Email: jennifer.martin@va.gov
Study Contact Backup
- Name: Diane I Lee, MSW
- Phone Number: 36087 (818) 891-7711
- Email: Diane.Lee@va.gov
Study Locations
-
-
California
-
Sepulveda, California, United States, 91343
- Recruiting
- VA Greater Los Angeles Healthcare System, Sepulveda, CA
-
Contact:
- Scott E Krahl, PhD MA BA
- Phone Number: 818-895-5861
- Email: scott.krahl@va.gov
-
Contact:
- Taigy T Gooding, DrPH
- Phone Number: 36025 (310) 478-3711
- Email: Taigy.Gooding@va.gov
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Principal Investigator:
- Jennifer L Martin, PhD
-
Sub-Investigator:
- Cathy A Alessi, MD MPH
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- community-dwelling Veterans aged 18 years and older,
- received care from VAGLAHS in the prior year,
- live within a 50-mile radius of the research offices at the VA Sepulveda Ambulatory Care Center,
- have symptoms of PTSD,
- have symptoms of insomnia.
Exclusion Criteria:
- current pregnancy or has a child less than 6 months of age (men and women),
- active substance users or in recovery with less than 90 days of sobriety,
- too ill to engage in the study procedures,
- unable to self-consent to participate,
- unstable housing (since we may not be able to retrieve costly and difficult to replace monitoring equipment),
- severe, untreated sleep disordered breathing (AHI>15 with excessive daytime sleepiness, or AHI>30),
- restless legs syndrome that accounts for the sleep disturbances reported,
- a circadian rhythm sleep disorder that accounts for the sleep disturbances reported (including shift work sleep disorder),
- unstable medical or psychiatric disorders (which is a contraindication for behavioral treatment of insomnia);
- remission of insomnia symptoms prior to randomization;
- current participation in prolonged exposure therapy for PTSD.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: The ABC of Insomnia (Acceptance and the Behavioral Changes to
This is the new treatment arm that is being compared to CBT-I, standard treatment for insomnia.
|
5 individual sessions incorporating behavioral treatment components plus acceptance and commitment therapy (ACT) provided by a trained instructor.
Other Names:
|
Active Comparator: Cognitive-Behavioral Therapy for Insomnia
This is the standard treatment for insomnia that is being compared to the new treatment (ABCI).
|
5 individual sessions incorporating behavioral and cognitive therapy components with a trained instructor.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
PTSD Check List for DSM-5 (PCL-5)
Time Frame: 6-months follow-up
|
The PCL-5 total score will be the main outcome measure for PTSD symptom severity.
The PCL-5 is a standardized assessment for PTSD, based on DSM-5.
The 20-item scale assesses the presence and severity PTSD symptoms on a 0-4 Likert scale, with a total symptom severity score range from 0-80.
A score greater than or equal to 33 is indicative of probable PTSD.
|
6-months follow-up
|
Insomnia Severity Index (ISI)
Time Frame: 6-months follow-up
|
Mean score on Insomnia Severity Index (ISI). This 7-item scale measures self-reported severity of insomnia symptoms. Total score ranges from 0 to 28, with higher scores indicating greater insomnia severity. |
6-months follow-up
|
Pittsburgh Sleep Quality Index (PSQI)
Time Frame: 6-months follow-up
|
Mean PSQI score will be used as a measure of sleep quality.
Scores range from 0 to 21.
Higher scores indicate worse sleep quality.
|
6-months follow-up
|
Sleep efficiency from 7-day sleep diary
Time Frame: 6-months follow-up
|
Sleep efficiency (mean percent time asleep while in bed) will be calculated from 7 days of self-reported sleep diary. Scores range from 0 to 100 percent. Higher scores indicate better outcome. |
6-months follow-up
|
Collaborators and Investigators
Investigators
- Principal Investigator: Jennifer L Martin, PhD, VA Greater Los Angeles Healthcare System, Sepulveda, CA
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- IIR 20-283
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
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