- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05314192
Non-invasive Assessment of Inflammatory Markers MIP-1 Alpha and IL-6 in Saliva of Post Myocardial Infarction and Stage 4 Periodontitis Patients
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This was a cross-sectional study involving the patients of the department of periodontics and department of cardiology.
Patients included in the study were categorized into four groups: (1) group 1-healthy subjects, (2) group 2-stage 4 periodontitis patients, (3) group 3- post-MI patients with stage 4 periodontitis, (4) group 4- post-MI patients without periodontitis.
The severity of the periodontitis was assessed by a periodontist. The diagnosis of acute MI was made by the cardiologists. Oral health assessment in acute MI patients was done at the subjects' bedside after stabilization of the patient, so as not to interfere with the ongoing medical treatment. Subjects' identification was kept confidential.
All samples were collected from patients admitted within 48 hours of their cardiac event. Patients were diagnosed as acute ST-elevation myocardial infarction (STEMI) based on the elevation of ST segments on the electrocardiogram(ECG) by 0.1mV in contiguous leads in patients with signs and symptoms of myocardial ischemia and/ or development of new left bundle branch block, along with increased cardiac biomarkers. Non-ST-elevation myocardial infarction (NSTEMI) was diagnosed in patients with signs and symptoms of myocardial ischemia and depression in ST-segment on the ECG or new Q wave pathology along with elevation of cardiac biomarkers.[8] Stage four periodontitis was diagnosed using the World Workshop 2017 classification.[9] Subjects who had undergone oral prophylaxis or periodontal surgery in the past 6 months were not included in the study. Smokers, pregnant women, lactating mothers, and those on medication (anti-microbial, non-steroidal anti-inflammatory drugs) in the past 3 months as well as those with other chronic systemic diseases were excluded from the study. These were all excluded as each would affect the levels of biomarkers.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
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Mangalore, India
- AB shetty Institute of dental sciences
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- subjects who had MI
- who had stage 4 periodontal disease
Exclusion Criteria:
- subjects who did not have MI
- subjects who had systemic disease other than MI
- subjects who had medication in the past 3 months
- smokers
- pregnant and lactating women
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Healthy
Healthy cohorts with no underlying systemic or periodontal disease
|
saliva was assessed for MIP-1 alpha
saliva was assessed for IL-6
|
stage 2 periodontitis
patients with periodontitis but no underlying systemic periodontal disease
|
saliva was assessed for MIP-1 alpha
saliva was assessed for IL-6
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MI patients with stage 4 periodontitis
patients who had MI and having stage 4 periodontitis patients
|
saliva was assessed for MIP-1 alpha
saliva was assessed for IL-6
|
MI patients without periodontitis
patients who had MI without periodontitis
|
saliva was assessed for MIP-1 alpha
saliva was assessed for IL-6
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
salivary test for MIP-1 alpha
Time Frame: 72 hours
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saliva was assessed for biomarker MIP-1 alpha among the 4 groups
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72 hours
|
salivary test for IL-6
Time Frame: 72 hours
|
saliva was assessed for biomarker IL-6 among the 4 groups
|
72 hours
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- ABSM/EC/29/2020
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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