- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05419973
Vitamin D Levels in Umbilical Cord and It's Impact on Infant and Children's Health (VITADi Study) (VITADi)
Study Overview
Status
Conditions
Detailed Description
Participants of this study are women in the third semester of pregnancy, who consented to be included with their babies in this study. Firstly, the parents will be given explanation regarding the study, and informed consent will be signed if they agree to participate. All the pregnant women who met the criteria will be recorded for their name, age, parity, birth and medical history. Anthropometric examination will be done on the pregnant women, to measure weight using standardized CEBA digital scale, height and upper arm circumference. Blood sampling will also be done to measure complete blood count, ferritin, Fe serum, vitamin D levels, calcium, parathyroid hormone, IL-6 and IL-10.
After the subjects give birth, the babies who met the criteria (aterm, birth weight > 2500 grams, with no congenital abnormalities and acute infection at birth) will also be included in this study. Measurement of birth weight, birth length, and head circumference will be carried out along with blood sampling by taking 3 ml of blood from umbilical cord, 1,5 ml each to measure the complete blood count, and other 1,5 ml to measure ferritin, Fe serum, vitamin D levels, vitamin D receptors, IL-6 and IL-10. Subjects will be monitored for 6 months, and two home visits will be done throughout the study at the age of 3 months and 6 months. During the visits, subjects will be measured for their weight, length, head circumference, as well as their nutritional status. Parents and guardians will also be asked questions regarding the incidence of diarrhea, allergic manifestations such as rash, and assessment will be made based on Hanifin Rajka criteria. At the age of 6 months old, blood sampling will be done again by taking 3 ml of the blood, 1,5 ml each to measure the complete blood count, and other 1,5 ml to measure ferritin, Fe serum, vitamin D levels, vitamin D receptors, IL-6 and IL-10.
The collected data then will be grouped based on the purpose and type of data, then univariate analysis and bivariate analysis will be performed. Univariate analysis will describe the characteristics of the basic data, in the form of frequency, mean value, standard deviation, and range. Meanwhile bivariate analysis such as Wilcoxon test will be performed to to analyse data with independent variables with an ordinal/numeric scale, the data are not normally distributed and have different variances. Mann-Whitney test will also be performed test to compare ordinal or numeric scale variables whose data are not normally distributed and have different variances between two unpaired groups.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Sri Hardiyanti Putri, MD
- Phone Number: 628114499339
- Email: srihardiyantiputri@gmail.com
Study Contact Backup
- Name: Bahrul Fikry, MD, PhD
- Phone Number: 6282123997492
- Email: bahrulfikri@unhas.ac.id
Study Locations
-
-
South Sulawesi
-
Makasar, South Sulawesi, Indonesia, 90245
- Recruiting
- Hasanuddin University
-
Contact:
- Sri Hardiyanti Putri, MD
- Phone Number: 628114499339
- Email: srihardiyantiputri@gmail.com
-
Contact:
- Bahrul Fikri, MD, PhD
- Phone Number: 6282123997492
- Email: bahrulfikri@unhas.ac.id
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Women in third trimester of pregnancy
- Agree to include their babies in this study
Exclusion Criteria:
- History of abortion
- Suffering from hypertension or preeclampsia
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Pregnant Women
Women in third semester of pregnancy who are willing to include their babies as samples for the next study, no history of abortion, and not suffering from hypertension and preeclampsia.
|
Weight, length, upper arm circumference
3 ml of blood will be taken, 1,5 ml each to measure the complete blood count, and other 1,5 ml to measure ferritin, Fe serum, vitamin D levels, vitamin D receptors, IL-6 and IL-10.
|
Infants
Babies born from mothers who are willing to be included in the study, aterm, with birth weight more than 2500 grams.
No congenital abnormalities at birth and no acute infection at birth.
|
3 ml of blood will be taken, 1,5 ml each to measure the complete blood count, and other 1,5 ml to measure ferritin, Fe serum, vitamin D levels, vitamin D receptors, IL-6 and IL-10.
birth weight, length, head circumference, nutritional status
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Vitamin D Levels
Time Frame: August 2022 - February 2023
|
Measured by blood sample collection
|
August 2022 - February 2023
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Hemoglobin levels
Time Frame: August 2022 - February 2023
|
Measured by blood sample collection
|
August 2022 - February 2023
|
IgE
Time Frame: August 2022 - February 2023
|
Measured by blood sample collection
|
August 2022 - February 2023
|
Atopic Dermatitis
Time Frame: August 2022 - February 2023
|
Skin rash, itchiness, patchy skin
|
August 2022 - February 2023
|
Diarrhea
Time Frame: August 2022 - February 2023
|
Incidence of diarrhea
|
August 2022 - February 2023
|
Hypertension
Time Frame: August 2022 - February 2023
|
Blood pressure obtained during visits
|
August 2022 - February 2023
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Sri Hardiyanti Putri, MD, Hasanuddin University
Publications and helpful links
Helpful Links
- Adams, JS, & Hewison, M. (2010). Update in vitamin D. Journal of Clinical Endocrinology and Metabolism, 95(2), 471-478.
- Akcakus, M., Koklu, E., Slave, N., Kula, M., Kurtoglu, S., & Koklu, S. (2006). The relationship between birthweight, 25-hydroxyvitamin D concentrations and bone mineral status in neonates. Annals of Tropical Paediatrics, 26(4), 267-275.
- Aluisio, AR, Maroof, Z., Chandramohan, D., Bruce, J., Zulf Mughal, M., Bhutta, Z., Walraven, G., Masher, MI, Ensink, JHJ, & Manaseki-Holland, S. (2013). Vitamin D3 supplementation and childhood diarrhea: A randomized controlled trial. Pediatrics, 132(4).
- Atkinson, MA, Melamed, ML, Kumar, J., Roy, CN, Miller, ER, 3rd, Furth, SL, & Fadrowski, JJ (2014). Vitamin D, race, and risk for anemia in children. The Journal of pediatrics, 164(1), 153-158.e1.
- Cadario, F., Savastio, S., Pozzi, E., Capelli, A., Dondi, E., Gatto, M., Zaffaroni, M., & Bona, G. (2013). Vitamin D status in cord blood and newborns: Ethnic differences. Italian Journal of Pediatrics, 39(1).
- Cerami, C. (2017). Iron Nutriture of the Fetus, Neonate, Infant, and Child. Annals of Nutrition and Metabolism, 71(3), 8-14.
- Cyprian, F., Lefkou, E., Varoudi, K., & Girardi, G. (2019). Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond. Frontiers in Immunology, 10.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- UH22030108
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ICF
- ANALYTIC_CODE
- CSR
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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