- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05444413
Platelet-rich Plasma in the Treatment of Intractable Postherpetic Neuralgia
Effect of Ultrasound-guided Platelet-Rich Plasma Nerve Block Combined With Drugs in the Treatment of Intractable Postherpetic Neuralgia
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
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Jiangsu
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Nantong, Jiangsu, China, 226000
- Affiliated Hospital of Nantong University
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Meet the diagnostic criteria of PHN: have a history of acute herpes zoster, the pain lasts for more than half a year, and there is paroxysmal pain in the affected nerve distribution area;
- Preoperative visual analog scale (VAS) score ≥ 5;
- Those who can cooperate with the treatment;
- We agreed to inject platelet rich plasma into nerve block under the guidance of ultrasound, and signed the informed consent form.
Exclusion Criteria:
- Systemic infection or puncture local infection;
- Serious disturbance of cardiovascular and cerebrovascular function;
- Abnormal bleeding and coagulation function or complicated with blood system diseases;
- Mental disorders;
- Severe dysfunction of important organs in the body
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: ultrasound-guided platelet rich plasma nerve block combined with drugs
selected patients were treated by the ultrasound-guided platelet rich plasma nerve block once a week for the 4 consecutive weeks while they were given the regular medicine which are taking pregabalin and amitriptyline hydrochloride orally, and the dosage shall be increased or decreased according to the patient's condition.
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selected persons are treated by ultrasound-guided platelet rich plasma nerve block and the regular medicine
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The changes from degree of pain that patients feel after the treatment are assessed by the numerical rating scale (NRS).
Time Frame: Change from the numerical rating scale at 6 months
|
This method is composed of 11 numbers from 0 to 10. Patients use 11 numbers from 0 to 10 to describe the intensity of pain.
(0="no pain"and 10=the "worst pain")
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Change from the numerical rating scale at 6 months
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The changes from degree of pain that patients feel after the treatment are also assessed by the Short-form McGill Pain Questionnaire(SF-MPQ).
Time Frame: Change from the total score of Short-form McGill Pain Questionnaire at 6 months
|
When evaluating item (1), ask the thinker questions one by one, and mark the corresponding level according to the pain level the thinker answers. When evaluating item (2), vas ruler shall be adopted. This ruler is a 10cm long swimming ruler with 10 graduations marked on one side and "0" and "10" at both ends, indicating no pain,"10" represents the most severe pain that the patient can't bear in his life. During clinical use, the side with scale is turned away from the patient, and the patient is asked to mark the corresponding position representing his pain level in the past day on the ruler. The evaluator evaluates the number of patients according to the position marked by the patient (for example, 5.4cm is 5.4 points), and records it in the table. When evaluating item (3), mark the corresponding score according to the patient's subjective feelings. Finally, the total scores of PRI, vas and PPI were evaluated. (The higher the total score, the more severe the pain) |
Change from the total score of Short-form McGill Pain Questionnaire at 6 months
|
The changes from degree of the patient' sleep quality after the treatment are assessed by the Athens Insomnia Scale.
Time Frame: Change from the patient' sleep quality at 6 months
|
Ask the examinee to carefully review his sleep experience in the past one month for questions ① - ⑧. If it happens to you at least three times a week, circle the corresponding self-assessment results. Then calculate the total score for evaluation. Assessment result judgment: (1) If the total score is less than 4, there is no sleep disorder: (2) if the total score is 4-6, it is suspected that there is a big sleep; (3) If the total score is above 6: Insomnia |
Change from the patient' sleep quality at 6 months
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Collaborators and Investigators
Investigators
- Study Director: yuan zhou, doctor, Affiliated Hospital of Nantong University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2022-K036
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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