Perception in Parkinson's Disease

May 24, 2023 updated by: Alice Cronin-Golomb, Boston University Charles River Campus
The investigators plan to examine the relation of perceptual variables-basic vision, unusual perceptual experiences(including but not limited to visual hallucinations)-to relevant functional variables such as cognition, mood, and alertness/sleepiness in an online sample of persons with Parkinson's disease (PwPD). It is hypothesized that unusual perceptual experiences will relate significantly to the selected variables. Participants do not need to experience visual hallucinations to be able to participate in this study. This is an observational study only, and not an interventional study.

Study Overview

Status

Recruiting

Conditions

Detailed Description

For this study, the investigators propose to conduct an online study of PwPD (proposing a total of 60 participants) to examine the relations among variables that may relate to perception in PD. Those PwPD who express interest will be sent a link to an online survey (Qualtrics). The investigators will collect demographic and health information, followed by questionnaires assessing unusual perceptual experiences, mood, motivation, sleep, fatigue and quality of life. The survey should take roughly 45 minutes to an hour to complete.

Compensation: A $20 Amazon gift card will be offered to those who complete the survey all the way through with good effort.

Study Type

Observational

Enrollment (Estimated)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Shraddha B Kinger, MA
  • Phone Number: 617-901-6168
  • Email: shradk@bu.edu

Study Locations

  • United States
    • Massachusetts
      • Boston, Massachusetts, United States, 02215
        • Recruiting
        • Vision and Cognition Laboratory, Boston University
        • Contact:
          • Alice Cronin-Golomb, PhD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 110 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

PwPD volunteering for an online study

Description

Inclusion Criteria:

  • Participants must be at least 40 years old
  • Have a self-reported diagnosis of idiopathic PD
  • Be proficient English speakers
  • Have functional vision
  • Have internet access, and access to a desktop computer or laptop

Exclusion Criteria:

  • Self-reported poor vision (non-functional range)
  • Lack of access to internet and either a desktop computer or laptop

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Only
  • Time Perspectives: Cross-Sectional

Cohorts and Interventions

Group / Cohort
Persons with Parkinson's disease (PwPD)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Noise Pareidolia Test
Time Frame: Baseline
Assesses tendency to see meaningful objects such as faces, animals, and objects in ambiguous patterns. Higher scores (on items with no face) indicate a higher number of pareidolic responses.
Baseline
Mooney Faces
Time Frame: Baseline
Assesses the ability to see an upright, inverted, or scrambled face in a black and white pattern. Higher scores (on items with no face) indicate a higher number of pareidolic responses.
Baseline
BU Hallucinations and Unusual Perceptual Experiences questionnaire (BU-HUPE)
Time Frame: Baseline
Assesses different types of visual hallucinations - simple VH; illusions; minor hallucinations: vivid sense of presence or movement in periphery (passage); and complex VH (e.g., people, animals, objects), as well as temporal and descriptive characteristics of the hallucinations. Higher scores indicate more unusual perceptual experiences.
Baseline
Prodromal Questionnaire, Brief Version (PQ-B)
Time Frame: Baseline
Assesses risk for psychosis by asking about positive symptoms and related distress/impairment. Higher scores indicate higher risk for psychosis and higher related distress.
Baseline
Parkinson's Disease - Psychotic Symptoms Scale (PD-PSS)
Time Frame: Baseline
Assesses the frequency and severity of minor hallucinations (passage hallucinations, presence hallucinations, visual illusions), and structured hallucinations in PD. Higher scores indicate higher frequency of psychotic symptoms.
Baseline
Penn Online Evaluation of Migraine (POEM)
Time Frame: Baseline
Assesses headaches and migraine-related history.
Baseline
Epworth Sleepiness Scale (ESS)
Time Frame: Baseline
Assesses a person's general level of daytime sleepiness. Maximum Score: 24. Higher scores indicate a higher chance of dozing.
Baseline
Parkinson's Disease Sleep Scale-2
Time Frame: Baseline
Assesses sleep and nocturnal disturbances in Parkinson's disease. Maximum score: 60. Higher scores indicate more frequent sleep disturbances.
Baseline
Parkinson's Anxiety Scale (PAS)
Time Frame: Baseline
Assesses the severity of anxiety symptoms in persons with Parkinson's disease. Maximum score:48. Higher scores indicate more severe anxiety.
Baseline
Center for Epidemiological Studies Depression Scale (CES-D)
Time Frame: Baseline
Assesses depressive symptoms in the general population. Maximum score:60. Higher scores indicate more severe depression.
Baseline
Parkinson's Disease Questionnaire - 39 (PDQ-39)
Time Frame: Baseline
Assesses Parkinson's disease-specific health-related quality of life. Higher scores indicate worse quality of life.
Baseline
NIH NeuroQoL measures
Time Frame: Baseline
Assesses health-related quality of life in adults with neurological disorders. Higher scores on the sub-scales indicate worse outcomes.
Baseline
The Movement Disorders Society Unified Parkinson Disease Rating Scale (MDS-UPDRS)
Time Frame: Baseline
Assesses motor and non-motor experiences of daily living in Parkinson's disease. Higher scores indicate increased severity of motor and non-motor symptoms.
Baseline
Non-Motor Symptoms Questionnaire (NMSQ)
Time Frame: Baseline
Assesses a range of non-motor symptoms in Parkinson's disease. Higher scores indicate the presence of more non-motor symptoms.
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Boston University Charles River Campus

Investigators

  • Principal Investigator: Alice Cronin-Golomb, PhD, Boston University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2022

Primary Completion (Estimated)

September 1, 2024

Study Completion (Estimated)

September 1, 2024

Study Registration Dates

First Submitted

July 29, 2022

First Submitted That Met QC Criteria

July 29, 2022

First Posted (Actual)

August 1, 2022

Study Record Updates

Last Update Posted (Actual)

May 26, 2023

Last Update Submitted That Met QC Criteria

May 24, 2023

Last Verified

May 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 6350X

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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