- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05501587
Measures of Respiratory Health Registry (MRH)
Study Overview
Status
Conditions
Detailed Description
The scope of the registry is to collect data on small airways function in healthy children, children with cystic fibrosis (CF) and children with non-CF respiratory disease using the multiple breath washout (MBW) system. These data will be stored along with demographic data, clinical data, and traditional pulmonary function testing (PFT) data. The MBW data will be collected with concurrent with clinically indicated PFT testing.
The purpose of the registry is to 1/ establish a locally collected normal range of small airways function across the paediatric age range and 2/ to collect these measurements in CF and non-CF respiratory disease.
Ultimately, the objective of this registry is to validate MBW technology as a tool that can be utilized in clinical care.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Rodrigo Sandoval, MSc
- Phone Number: 2928 6048752345
- Email: Rodrigo.Sandoval@bcchr.ca
Study Contact Backup
- Name: Alam Lakhani
- Phone Number: 7606 6048752345
- Email: alam.lakhani@cw.bc.ca
Study Locations
-
-
British Columbia
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Vancouver, British Columbia, Canada, V6H 3N1
- Recruiting
- British Columbia Children's Hospital
-
Contact:
- Rodrigo Sandoval, MSc
- Phone Number: 2928 6048752345
- Email: Rodrigo.Sandoval@bcchr.ca
-
Contact:
- Alam Lakhani
- Phone Number: 7606 6048752345
- Email: alam.lakhani@cw.bc.ca
-
Principal Investigator:
- Jonathan Rayment, MDCM, MSc
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Participants with CF
Inclusion Criteria:
-Diagnosis of CF as evidenced by one or more clinical feature consistent with the CF phenotype or positive CF newborn screen AND one or more of the following criteria: i. A documented sweat chloride ≥ 60 mEq/L by quantitative pilocarpine iontophoresis (QPIT).
ii. A documented genotype with two disease-causing mutations in the CFTR gene.
- In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing
Exclusion Criteria:
- Physical findings at the screening that would compromise the safety of the participant or the quality of the data (e.g. respiratory distress or work of breathing)
- Requirement of supplementary oxygen to maintain oxygen saturation above 95%
Participants with other Respiratory Disease
Inclusion criteria:
- Physician-diagnosed lung disease
- Informed consent by participant, parent, or legal guardian
- In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing
Exclusion criteria
- Physical findings at screening that would compromise the safety of the participant or the quality of the research data
- Requirement of supplementary oxygen to maintain oxygen saturation above 95%
Healthy Participants
- Inclusion criteria
- Informed consent by participant, parent, or legal guardian
- In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing
Exclusion criteria
- Physical findings at screening that would compromise the safety of the participant or the quality of the research data
- Evidence of lung disease
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Healthy Participants
|
Participants with CF
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Participants with other Respiratory Disease
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
To validate new lung function testing technologies
Time Frame: 10 years
|
The ultimate objective of this registry is to validate new lung function testing technologies as tools that can be utilized in clinical care.
|
10 years
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Jonathan Rayment, MDCM, MSc, University of British Columbia
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- H18-00812
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Access Criteria
Criteria for access to the MRH-Registry Data:
The Proposed Study must demonstrate approval by a Qualified REB The objectives of the Proposed Study must align with the scientific objectives of the iMRH-Registry Use of the MRH Registry Data in the Proposed Study must respect the informed consent given by the participants of the iMRH Registry; The Proposed Study must have scientific merit, as assessed by the MRH Registry Data Access Committee The User-Investigator must demonstrate sufficient funding to perform the Proposed Study.
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ICF
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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