Prospective Study and Analysis of Biomechanical Parameters of Human Movement Based on Disability Indicators in Older Adults (MOBA-P)

Study and Analysis of Biomechanical Parameters of Human Movement Based on Disability Indicators in Older Adults Based on a Multifactorial Analysis: a Prospective Cohort Study

Mobility loss in older people is caused by a variety of aging impairments in various body systems.The disability, which includes physical impairments and resulting activity limitations or participation restrictions, can arise acutely from a catastrophic illness or, more commonly, from subacute functional decline without a clear triggering event. Lower physical functioning was associated with higher healthcare utilization and expenditures, leading to a large burden on government-funded healthcare services. Early identification of mobility changes and intervening in them would likely be the most effective strategy to reduce the burden of disability in the population. Overall, there is a need to develop strategies to reduce disability among older adults in which kinetic and kinematic characteristics are used to predict disability status.

Accordingly, the purpose of this prospective cohort is to identify biomechanical parameters, from the gait, sit-to-stand, timed up and go, stair ascend and descend, and quiet standing functional tasks, as predictors of changes in health and disability status in older adults.

This research was funded by Fundação para a Ciência e Tecnologia (FCT), NORTE 2020, and European Social Fund of European Union, grant number 2020.05356.BD and through R&D Units funding (UIDB/05210/2020), Fundação para a Ciência e Tecnologia (FCT), Portugal and the European Union.

Study Overview

• Status: Recruiting
• Conditions: Disability
• Intervention / Treatment: Other: Exposure to disability

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

• Study Contact: Name: Juliana S Moreira, Msc; Phone Number: +351 222 061 000; Email: jmo@ess.ipp.pt

Study Locations

• Portugal
  • Porto, Portugal, 4200
    • Recruiting
    • Center for Rehabilitation Research, School of Health, Polytechnic of Porto, Portugal
    • Contact: Juliana S Moreira, Msc; Phone Number: +351 222 061 000; Email: jmo@ess.ipp.pt

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 58 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Portuguese community-dwelling older adults

Description

Inclusion Criteria:

• older adults, 60 years or over;
• community-dwelling;
• able to perform the tasks (gait, sit-to-stand, climb and descend stairs) independently;

Exclusion Criteria:

• older adults who are institutionalized;
• older adults who have established diagnosis of malignancy or terminal diseases with an anticipated survival of less than 1 year;
• older adults who have stroke history, cerebral hemorrhage, head trauma, or Parkinson's disease;
• older adults who have cognitive impairment, specifically Mini Mental StateExamination (Portuguese version) score of 22 for 0 to 2 years of literacy, 24 for 3 to6 years of literacy and 27 for more than 6 years of literacy (Morgado et al., 2009);
• older adults who have rheumatic pathologies that interfere with the tasks performance;
• older adults who have diabetic foot, lower limb fracture less than 6 weeks, or other related conditions;
• older adults who have unstable cardiovascular disease, liver or renal function failure;
• older adults who have a body mass index greater than or equal to 30 kg/m2;
• older adults who vestibular and/or audition or vision impairments non corrected that influence the performance of tasks;
• older adults who presence of symptoms at the time of evaluation that influences the participant performance of tasks.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Healthy older Adults; Healthy older Adults: older adults without disability indicators	Other: Exposure to disability; Disability status assessed by functional measures
Disability Older Adults; Disability Older Adults: older adults with disability indicators	Other: Exposure to disability; Disability status assessed by functional measures

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Waveforms from full-body joint angles	Waveforms from full-body joint angles measured in degrees (°)	Assessed once at study entry.
Waveform from full-body angular joint velocities	Waveform from angular joint velocities measured in degrees per second (°/s)	Assessed once at study entry
Waveform from lower limb joint moments	Waveform from lower limb joint moments measured in Newton-meter (kgm²/s²)	Assessed once at study entry
Waveform from total body energy	Waveform from total body energy measured in joules (J)	Assessed once at study entry
Waveform from full-body separate segment energy	Waveform from body segment energy un joules (J)	Assessed once at study entry
Waveform from lower body joint forces	Waveform from lower body joint forces measured in Newton (N)	Assessed once at study entry
Waveform from lower body joint power	Waveform from lower body joint power measured in Watts	Assessed once at study entry
Waveform from centre of mass displacement	Waveform from centre of mass displacement in m/s	Assessed once at study entry
Waveform from centre of pressure displacement	Waveform from centre of pressure displacement in m/s	Assessed once at study entry
International Physical Activity Questionnaire	IPAQ is questionnaire to assess self-reported physical activity	Assessed at study entry and evaluated every three months until the end of 1 year
Mini-Mental State Examination (MMSE)	MMSE provides a brief screening test that quantitatively assesses the severity of cognitive impairment and documents cognitive changes occurring over time	Assessed at study entry and evaluated every three months until the end of 1 year
Barthel Index	The Barthel Index is an instrument that assesses the individual's level of independence for ten activities of daily living	Assessed at study entry and evaluated every three months until the end of 1 year
Lawton and Brody Instrumental Activities of Daily Living Scale	Lawton and Brody Instrumental Activities of Daily Living Scale assess the instrumental ADLs necessary for living in the community	Assessed at study entry and evaluated every three months until the end of 1 year
Number of health conditions	Total number and description of health conditions	Assessed at study entry and evaluated every three months until the end of 1 year
Number of falls	Total number and description of ocurrences of falls	Assessed at study entry and evaluated every three months until the end of 1 year

Collaborators and Investigators

• Sponsor: Polytechnic Institute of Porto
• Collaborators: School of Allied Health Sciences of Porto (ESTSP) - Polytechnic Institute of Porto (IPP); Center for Rehabilitation Research - Polytechnic Institute of Porto (IPP); Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2022
• Primary Completion (Anticipated): May 31, 2024
• Study Completion (Anticipated): July 31, 2024

Study Registration Dates

• First Submitted: November 18, 2022
• First Submitted That Met QC Criteria: December 12, 2022
• First Posted (Actual): December 19, 2022

Study Record Updates

• Last Update Posted (Actual): December 19, 2022
• Last Update Submitted That Met QC Criteria: December 12, 2022
• Last Verified: December 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: CE0077C; 2020.05356.BD (Other Grant/Funding Number: Fundação para a Ciência e Tecnologia, NORTE 2020, FSE EU); UIDB/05210/2020 (Other Grant/Funding Number: Fundação para a Ciência e Tecnologia (FCT), Portugal and the European Union (EU))

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No