- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05679999
Carotid Artery Intima Media Thickness Can Predict the Response to Phosphodiesterase 5 Inhibitors in the Patients With Moderate Erectile Dysfunction
January 11, 2023 updated by: Sedat Önen, Bursa City Hospital
The aim of the present study was to examine the relationship between degrees of erectile dysfunction and carotid artery intima media thickness (CIMT) and its effect on the medical treatment of this disease.
Considering that there are vascular pathologies in the etiology, it is important to reveal vascular disorders with CIMT, which is a non-invasive, easily applicable method, and to use it in the grading and treatment of erectile dysfunction.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Background.
It is known that vasculogenic disorders play a leading role in the pathophysiology of erectile dysfunction.
Cardiovascular risk factors that cause vascular pathologies are also the main actors among the causes of erectile dysfunction.
The thickness of the carotid artery intima-media (CIMT) is useful for demonstrate cardiovascular disorders.
For this reason, the relationship between CIMT and erectile dysfunction and its use in predicting the response to phosphodiesterase 5 inhibitors (PDE5-I) are encountered in the literature.
In this study, the investigators also evaluated the predictive value of CIMT in subgroups of patients according to the severity of erectile dysfunction.
Methods.
A total of 181 subjects were divided into two groups as patient group (n:150) and control group (n:31).
The patients were also divided into subgroups as severe, moderate, mild-moderate, mild erectile dysfunction.
Blood tests, carotid ultrasonography and The International Erectile Function Index-5 form (IIEF-5) were applied to all subjects.
Tadalafil was administered to each patient.
The patients were re-evaluated using the IIEF-5 questionnaire after 2 months of treatment period.
According to response to medication, patients were also divided into subgroups as responders and non-responders.
Results.
Fasting blood glucose, BMI, IIEF score and CIMT were significantly higher in the patient group compared to the control group.
The thickness of the carotid artery intima-media thickness was significantly correlated with IIEF-5 score.
When the total patient group is evaluated, CIMT value of the responders was significantly lower compared to the non-responders.
Carotid artery intima-media was significantly higher in nonresponders of patients with moderate/mild-moderate erectile dysfunction compared to responders, while there were no significant difference in CIMT between responders and non-responders of patients with severe/mild erectile dysfunction.
Discussion.
In patients with moderate/mild-moderate erectile dysfunction, increased CIMT is associated with an nonresponse to PDE5-I.
Study Type
Observational
Enrollment (Actual)
181
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Bursa, Turkey
- Bursa Yuksek Ihtisas Training and Research Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years to 70 years (Adult, Older Adult)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
Male
Sampling Method
Non-Probability Sample
Study Population
Patients over 40 years of age and under 70 years old with erectile dysfunction
Description
Inclusion Criteria:
1. Patients over 40 years of age and under 70 years
Exclusion Criteria:
- Patients under 40 years of age and over 70 years old
- Patients whose consent can not be obtained
- Those with endocrine disease except type II diabetes mellitus
- Concomitant malignancy
6. Psychiatric problems 7. Previous penile or pelvic surgery/trauma 8. Penile curvature / Peyronie's disease 9. Patients receiving treatment for erectile dysfunction 10. Chronic liver failure 11. Chronic kidney failure 12. Neurological disease 13. Patients with low testosteron level (≤300 ng/dL)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Control group
31 male volunteers who did not have erectile dysfunction
|
Carotid artery intima media thickness measurement with ultrasound
|
Patient group
150 patients with erectile dysfunction
|
Carotid artery intima media thickness measurement with ultrasound
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Coexistence of erectile dysfunction and increased CIMT
Time Frame: 2 years
|
Association erectile dysfunction with CIMT measurement
|
2 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2018
Primary Completion (Actual)
December 31, 2019
Study Completion (Actual)
December 31, 2019
Study Registration Dates
First Submitted
December 26, 2022
First Submitted That Met QC Criteria
December 26, 2022
First Posted (Actual)
January 11, 2023
Study Record Updates
Last Update Posted (Actual)
January 12, 2023
Last Update Submitted That Met QC Criteria
January 11, 2023
Last Verified
January 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2014/23-01
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Undecided
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Clinical Trials on CIMT (Carotid artery intima media thickness measurement)
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