Pressure Controlled Ventilation Versus Volume Controlled Ventilation in Upper Abdominal Surgery

Comparison of Pressure and Volume Controlled Ventilation in Terms of Mechanical Power in Upper Abdominal Surgery

Comparison of mechanical powers produced at volume controlled and pressure controlled mechanical ventilation

Study Overview

• Status: Completed
• Conditions: Ventilator Lung
• Intervention / Treatment: Other: Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes; Other: Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes

Detailed Description

The mechanical power created by mechanical ventilation, as a new concept, can enable to evaluate the effect of different components in the lung.Our aim in this study is to calculate mechanical power in different ventilation modes ( pressure controlled and volume controlled ventilation) and to compare them. To calculate the mechanical powers we will use Van der Meijden's mechanical power formula for pressure controlled ventilation and for volume controlled ventilation we will use Gattinoni's mechanical power formula. In the literature we haven't seen any publication comparing the mechanical power of two commonly used ventilation modes (volume controlled and pressure controlled ventilation)

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey, 34093
    • Istanbul University, Department of Anesthesiology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• ASA1-2 , >18 years old patients having upper abdominal surgery

Exclusion Criteria:

• chronic obstructive lung disease, interstitial lung disease
• chronic renal failure
• Child-Pugh > 6 liver disease
• Patients who don't give consent
• NYHA > 2 heart failure

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Group 1; group 1 starts with volume controlled ventilation	Other: Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes; group 1 starts with volume controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to pressure controlled ventilation after letting washout we take three consecutive measurements at pressure controlled ventilation and we will repeat this protocol during surgery
Other: Group 2; group 2 starts with pressure controlled ventilation	Other: Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes; group 2 starts with pressure controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to volume controlled ventilation after letting washout we take three consecutive measurements at volume controlled ventilation and we will repeat this protocol during surgery

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
calculation of mechanical power changes in two different ventilation modes	mechanical power will be calculated using the Van der Meijden's formula for pressure support ventilation and Gattinoni's formula for volume controlled ventilation and two mechanical powers will be compared	change from at the beginning of surgery till the end of surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
postoperative pulmonary complications	postoperative pulmonary complication including pneumonia, acute lung injury, respiratory failure requiring reintubation	post-operative 7 days
hospitalisation time	up to 20 days	up to 20 days

Collaborators and Investigators

• Sponsor: Istanbul University
• Investigators: Principal Investigator: Istanbul University, Istanbul University

Publications and helpful links

General Publications

• Gattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M. The future of mechanical ventilation: lessons from the present and the past. Crit Care. 2017 Jul 12;21(1):183. doi: 10.1186/s13054-017-1750-x.
• van der Meijden S, Molenaar M, Somhorst P, Schoe A. Calculating mechanical power for pressure-controlled ventilation. Intensive Care Med. 2019 Oct;45(10):1495-1497. doi: 10.1007/s00134-019-05698-8. Epub 2019 Jul 29. No abstract available.

Study record dates

Study Major Dates

• Study Start (Actual): September 5, 2022
• Primary Completion (Actual): November 5, 2022
• Study Completion (Actual): December 5, 2022

Study Registration Dates

• First Submitted: October 18, 2022
• First Submitted That Met QC Criteria: January 18, 2023
• First Posted (Estimate): January 19, 2023

Study Record Updates

• Last Update Posted (Estimate): January 19, 2023
• Last Update Submitted That Met QC Criteria: January 18, 2023
• Last Verified: January 1, 2023

More Information

Terms related to this study

• Keywords: volume controlled ventilation; pressure controlled ventilation; mechanical power
• Other Study ID Numbers: 2021-2081

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No