The Influence of Endurance Sports Activity on the Oral Microbiota of Young Adults. (ORAMICAP)

Sport and Health a Pilot Study: Impact of Endurance Physical Activity on the Microbiological Homeostasis of the Oral Cavity of Young Adults

The oral cavity is an easily accessible anatomical site that accurately reflects the health of the individual. The mouth is considered an early indicator of biological aging, leading to the identification of oral biomarkers predictive of future alterations. Current data show that the oral health of high level athletes is globally altered with an increase in cariogenic indexes, an increased incidence of periodontitis, dental trauma and dry mouth syndromes. Few studies have focused on the oral microbiota compared to mouthguards used in rugby or boxing which seem to induce dysbiosis, a recent study shows an effect of ketogenic diet on bacterial changes in the mouth of endurance athletes. This project focuses on the impact of intensive sport practice on oral health and the identification of oral biomarkers associated with physical activity. The objective of this study is to investigate the impact of the amount of endurance sport practice on oral microbiota and oral health in young adults. the hypothesis is that a sedentary lifestyle and high-level sport induce depletion and/or changes in the oral microbiota compared to regular physical activity.

Study Overview

• Status: Not yet recruiting
• Conditions: Microbial Colonization
• Intervention / Treatment: Other: salivar and gum sampling

• Study Type: Interventional
• Enrollment (Anticipated): 200
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Margaux DUBOIS, PH; Phone Number: 0489152267; Email: Margaux.DUBOIS@univ-cotedazur.fr
• Study Contact Backup: Name: Morgane Ortis, PH; Phone Number: 0489152267; Email: Morgane.ORTIS@univ-cotedazur.fr

Study Locations

• France
  • Nice, France, 06000
    • Nice University Hospital
    • Contact: Margaux Dubois; Phone Number: 04.89.15.22.67; Email: Margaux.DUBOIS@univ-cotedazur.fr
    • Contact: Morgane Ortis; Phone Number: 0489152267; Email: Morgane.ORTIS@univ-cotedazur.fr
    • Principal Investigator: Margaux Dubois

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Be between 18 and 30 years old
• If practicing sports, it must be an endurance sport as main activity (cycling or running)

Exclusion Criteria:

• Practice more than 3 hours of swimming per week
• Have taken anti-inflammatory drugs, less than 48 hours before the study
• Have taken antibiotics and/or probiotics, less than 3 weeks before the study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: sedentary; Participant does not meet WHO's recommendations with the physical activity	Other: salivar and gum sampling; Saliva will then be collected by salivary spit and a mucosal smear will be taken using a swab passed at the junction of the tooth and the gum
Other: OMS recommandations; Participant does not meet WHO's recommendations (2.5-5 hours per week of moderate physical activity OR 1.25-2.5 hours per week of vigorous physical activity);	Other: salivar and gum sampling; Saliva will then be collected by salivary spit and a mucosal smear will be taken using a swab passed at the junction of the tooth and the gum
Other: More than the OMS recommandations; Participant is practicing physical activity more than the WHO recommendations	Other: salivar and gum sampling; Saliva will then be collected by salivary spit and a mucosal smear will be taken using a swab passed at the junction of the tooth and the gum

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Analysis of the oral microbiota in healthy individuals engaged in endurance physical activity at different levels.	Microbiological screening will be performed using an innovative methodology based on microfluidic PCR (BiomarkHD) (number of bacterial colonies)	3 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Quantification of salivary inflammatory markers in healthy individuals who perform endurance physical activity at different levels.	numer and type of salivary inflammatory markers will performed using multiplex analysis technology developed by the firm Meso Scale Diagnostic (MSD).	3 years

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Nice

Study record dates

Study Major Dates

• Study Start (Anticipated): March 15, 2023
• Primary Completion (Anticipated): March 15, 2026
• Study Completion (Anticipated): March 15, 2026

Study Registration Dates

• First Submitted: March 1, 2023
• First Submitted That Met QC Criteria: March 1, 2023
• First Posted (Actual): March 13, 2023

Study Record Updates

• Last Update Posted (Actual): March 13, 2023
• Last Update Submitted That Met QC Criteria: March 1, 2023
• Last Verified: March 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Infections; Communicable Diseases
• Other Study ID Numbers: 22-PP-11

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No