- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05930145
Results of the Use of Two Stentrievers Simultaneosly Compared With One as a Primary Treatment in Acute Ischemic Stroke
A Randomized Study Comparing the Effectiveness and Security of the Use of Two Stentrievers Simultaneously Versus One Stentriever as a Primary Treatment in Acute Ischemic Stroke Patients.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The use of a double stent retriever has been proposed as a safe and effective technique. The investigators hypothesized that the use of double stentriever primary could lead to higher first pass effect rates and better outcomes compared to single stentriever primary.
Our goal is to develop a research project to provide additional information on the potential benefits of the simultaneous double stent approach primarily in stroke patients receiving endovascular treatment.
A randomized study to compare the efficacy of double primary stentriever versus single primary stentriever.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: PEDRO VEGA VALDES, MD, PhD
- Phone Number: 39116 0034985108000
- Email: peveval@yahoo.es
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- A new disabling focal neurological deficit compatible with acute cerebral ischemia.
- Any age. Informed consent obtained from the patient or representative.
- NIHSS score ≥ 6.
- Pre-existing functional clinical status less than or equal to 2 according to the mRS clinical scale.
- Maximum time of 24 hours from symptom onset to arterial puncture. • TICI 0-1 in the diagnosed TICA (terminal internal carotid artery) , MCA (middle cerebral artery), and BA( basilar artery confirmed by angioCT and angiography).
- ASPECTs score on baseline CT greater than or equal to 6.
- In cases where it is indicated, prior intravenous fibrinolysis will be administered according to the protocols of each center.
Exclusion Criteria:
- Those described in the usual protocols for mechanical thrombectomy of each hospital.
- Pre-existing functional clinical status greater than 2 according to the mRS clinical scale
- Patients with tandem lesions of dissection or arteriosclerotic origin located in the extracranial internal carotid artery.
- Initiation of treatment with a different technique than the one described.
- Inability to use a proximal balloon guide catheter.
- Use of aspiration catheter.
- Intracranial atherosclerotic plaque as the cause of occlusion.
- Advanced or terminal disease with a life expectancy of less than 6 months.
- Patient who is participating in another study that may affect this one.
- ASPECTS score less than or equal to 6 on baseline CT.
- Evidence of significant hemorrhage or mass effect with midline shift on baseline CT.
- Patients with occlusions in multiple vascular territories.
- Evidence of intracranial tumor (except for small meningiomas)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Double stentriever technique
Patients treated with thrombectomy with a proximal balloon guiding catheter using two stentrievers simultaneously (one of 6 mm x 50 mm and another of 6 mm x 50 mm or 4 mm x 35 mm)
|
Double stentriever technique
|
Active Comparator: Single stentriever technique
Patients treated with thrombectomy with a proximal balloon guiding catheter using one stentriever (6 mm x 50 mm).
|
Single stentriever technique
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
EFFECTIVENESS OBJECTIVE: Complete recanalization on first pass
Time Frame: 90 days
|
Comparison of the complete recanalization rate in the first pass in the double stent group compared to the single stent group, defined as TICI greater than 2c on the Thrombolysis in Cerebral Infarction scale (eTICI scale).
|
90 days
|
SAFETY OBJECTIVE: Intracerebral hemorrhage.
Time Frame: 24 hours
|
Rate of patients with symptomatic intracranial hemorrhage (neurological deterioration in National Institutes of Health Stroke Scale [NIHSS] >4) at 24h observed between both groups and, fundamentally, evaluated by CT.
|
24 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Modified Rankin Scale (mRS) scale at 90 days.
Time Frame: 90 days
|
Modified Rankin Scale (mRS; range 0 [no symptoms] to 6 [death] for the evaluation of neurological functional disability score at 90 days
|
90 days
|
Mortality rate.
Time Frame: 90 days
|
90-day mortality rate.
|
90 days
|
Intervention success.
Time Frame: During the procedure
|
Rate of the ability to position both STs in the indicated location.
|
During the procedure
|
Complications related to the intervention.
Time Frame: During the procedure
|
Evaluation of the rate of arterial perforation, angiographic extravasation of contrast, arterial dissection or arterial vasospasm.
|
During the procedure
|
Embolism in new territories.
Time Frame: During the procedure
|
Rate of embolization to an artery not involved in the initially affected territory.
|
During the procedure
|
Number of passes with the devices.
Time Frame: During the procedure
|
Evaluation of the number of passes with the devices during the procedure.
|
During the procedure
|
Procedure time.
Time Frame: During the procedure
|
Time from arterial puncture to arterial recanalization, or if not achieved, until the end of the intervention.
|
During the procedure
|
Arterial Recanalization (eTICI scale) on first pass.
Time Frame: During the procedure
|
evaluation of the rates of eTICI 3, eTICI 2c/3, eTICI e2b/3 on the Thrombolysis in Cerebral Infarction scale (e TICI scale); range 0-3, with highest score indicating complete recanalization.
|
During the procedure
|
Arterial recanalization at the end of the procedures.
Time Frame: During the procedure
|
eTICI 3, eTICI e2c/3, eTICI e2b/3 at the end of the procedure on the Thrombolysis in Cerebral Infarction scale (e TICI scale); range 0-3, with highest score indicating complete recanalization.
|
During the procedure
|
Intracerebral hemorrhage.
Time Frame: 24 hours
|
Rate of any type of intracranial hemorrhage on the 24-hour control computed tomography (CT) scan (subarachnoid hemorrhage and hemorrhage according to the classification used in the ECASS study).
|
24 hours
|
Early neurological improvement.
Time Frame: 24 hours
|
Rate of patients with a decrease of 10 points or more on the NIHSS scale or complete recovery during the first 24 hours.
Improvement of Neurological status at 24 hours, determined by National Institutes of Health Stroke Scale [NIHSS score] range 0-42, with higher scores indicating greater stroke severity.
|
24 hours
|
National Institutes of Health Stroke Scale (NIHSS) scale at 24 hours, on day 5, or at discharge.
Time Frame: 5 days
|
Neurological status at 24 hours, at day 5 (+/- 12 hours) or discharge, determined by National Institutes of Health Stroke Scale [NIHSS score] range 0-42, with higher scores indicating greater stroke severity.
|
5 days
|
Collaborators and Investigators
Publications and helpful links
General Publications
- Vega P, Murias E, Jimenez JM, Chaviano J, Rodriguez J, Calleja S, Delgado M, Benavente L, Castanon M, Puig J, Cigarran H, Arias F, Chapot R. First-line Double Stentriever Thrombectomy for M1/TICA Occlusions : Initial Experiences. Clin Neuroradiol. 2022 Dec;32(4):971-977. doi: 10.1007/s00062-022-01161-2. Epub 2022 Apr 13.
- Li J, Tiberi R, Canals P, Vargas D, Castano O, Molina M, Tomasello A, Ribo M. Double stent-retriever as the first-line approach in mechanical thrombectomy: a randomized in vitro evaluation. J Neurointerv Surg. 2023 Jan 10:jnis-2022-019887. doi: 10.1136/jnis-2022-019887. Online ahead of print.
- Okada H, Matsuda Y, Chung J, Crowley RW, Lopes DK. Utility of a Y-configured stentriever technique as a rescue method of thrombectomy for an intractable rooted thrombus located on the middle cerebral artery bifurcation: technical note. Neurosurg Focus. 2017 Apr;42(4):E17. doi: 10.3171/2017.1.FOCUS16511.
- Cabral LS, Mont'Alverne F, Silva HC, Passos Filho PE, Magalhaes PSC, Bianchin MM, Nogueira RG. Device size selection can enhance Y-stentrieving efficacy and safety as a rescue strategy in stroke thrombectomy. J Neurointerv Surg. 2022 Jun;14(6):558-563. doi: 10.1136/neurintsurg-2021-017751. Epub 2021 Jul 7.
- Li Z, Liu P, Zhang L, Zhang Y, Fang Y, Xing P, Huang Q, Yang P, Liu J. Y-Stent Rescue Technique for Failed Thrombectomy in Patients With Large Vessel Occlusion: A Case Series and Pooled Analysis. Front Neurol. 2020 Aug 27;11:924. doi: 10.3389/fneur.2020.00924. eCollection 2020.
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- PA 2023.156
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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