- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05973838
Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention (PRISM)
Peer-Delivered, Behavioral Activation Intervention to Improve Polysubstance Use and Retention in Mobile Telemedicine OUD Treatment in an Underserved, Rural Area
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
There is a significant burden of opioid and polysubstance use, disproportionately affecting underserved, rural areas of the US. Yet many rural communities are poorly equipped to meet the pressing need for addiction treatment, including medications for OUD (MOUD) and evidence-based interventions (EBIs) to address the rise in opioid use disorder (OUD) and co-occurring stimulant use.The availability of telemedicine aboard a mobile treatment unit (TM-MTU), led by University of Maryland Baltimore in partnership with Maryland Department of Health, has helped fill the void of rural practitioners by providing buprenorphine for OUD treatment in rural areas, however, OUD treatment retention remains an ongoing challenge, with polysubstance use and stimulant use exacerbating this. Peer recovery specialists (PRSs), trained individuals with their own lived experience with substance use disorder (SUD) and recovery, are a promising strategy to improve OUD treatment retention and polysubstance use via the TM-MTU using a reinforcement-based approach.
Behavioral activation (BA) may be a feasible, scalable, reinforcement-based approach for improving OUD treatment retention and reducing polysubstance use in rural areas. By targeting increases in positive reinforcement, BA has been found to be effective for improving SUD treatment retention, preventing future relapse, including for stimulant use specifically, and improving medication adherence (i.e., for HIV) among low-income, minority populations with SUD as well as depression, which is a barrier to MOUD retention. BA has been shown to be feasibly delivered by peers and community health workers.
This study proposes to evaluate the effectiveness, implementation, and cost-effectiveness of an adapted PRS-delivered BA approach on the TM-MTU ("Peer Activate-MTU") compared to enhanced treatment as usual (ETAU; facilitated referrals and general PRS support) for patients with OUD and other polysubstance use. The investigators propose a randomized Type 1 hybrid effectiveness-implementation trial (n=180) to evaluate Peer Activate-MTU compared to ETAU. Specific aims are to evaluate the effectiveness of Peer Activate-MTU over 12-months on polysubstance use, as well as OUD treatment retention and buprenorphine adherence. The investigators will also evaluate the implementation of Peer-Active-MTU, including feasibility, acceptability, fidelity, and adoption guided by RE-AIM.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Morgan S Anvari, BA
- Phone Number: 3014055095
- Email: manvari@umd.edu
Study Locations
-
-
Maryland
-
Baltimore, Maryland, United States, 21223
- Not yet recruiting
- University of Maryland Baltimore (UMD Drug Treatment Center)
-
Sub-Investigator:
- Annabelle M Belcher, PhD
-
Contact:
- Heather Fitzsimons
- Phone Number: 443-462-3400
- Email: hfitzsimons@som.umaryland.edu
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Principal Investigator:
- Sarah M Kattakuzhy, MD
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Sub-Investigator:
- Eric Weintraub, MD
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College Park, Maryland, United States, 20742
- Not yet recruiting
- University of Maryland, College Park
-
Contact:
- Jessica F Magidson, PhD
- Phone Number: 301-405-5095
- Email: jmagidso@umd.edu
-
Contact:
- Morgan S Anvari, BA
- Phone Number: 301-405-5095
- Email: manvari@umd.edu
-
Principal Investigator:
- Jessica F Magidson, PhD
-
Denton, Maryland, United States, 21629
- Recruiting
- Caroline County Behavioral Health
-
Contact:
- Jessica Tuel, MSW
- Phone Number: 410-479-8172
- Email: jessicam.tuel@maryland.gov
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
Patient participants in the RCT must be 18 or older; receive OUD treatment as part of the telemedicine program; and exhibit polysubstance use within the past three-months (i.e., use of one or more non-prescribed substances (excluding opioids and/or tobacco) by urine toxicology or self-report.
Exclusion Criteria:
- Demonstrating active, unstable or untreated psychiatric symptoms, including mania and/or psychosis that would interfere with study participation
- Inability to understand the study and provide informed consent in English
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Peer-Delivered Behavioral Activation ("Peer Activate")
Participants in the Peer Activate intervention will receive a PRS-delivered behavioral activation intervention to address barriers to retention in methadone treatment and increase substance-free, positive reinforcement to support retention and reduce polysubstance use.
|
The PRS-delivered Peer Activate intervention will consist of approximately six weekly "core" sessions (approximately 30 minutes-1 hour), and then 6 optional "booster" sessions to reinforce skill practice.
In Peer Activate sessions, participants will learn behavioral activation and problem-solving skills to reduce barriers to medication nonadherence and incorporate value-driven, substance-free, rewarding activities into their daily life to reduce polysubstance use and improve retention.
|
No Intervention: Treatment As Usual
Participants in the TAU group will receive enhanced treatment as usual, defined as MTU services as usual enhanced with additional community referrals and follow-ups on those referrals, in addition to regular meetings with an addiction medicine physician and PRS on the MTU.
Standard PRS contact typically includes connection to local resources and general peer support as needed.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Six-Month Polysubstance Use Urinalysis
Time Frame: Measured from baseline to 6-month follow-up
|
Polysubstance use will be assessed using urinalysis.
Urine samples are collected at each visit and sent out for toxicological analysis using a customized panel composed of 40 analytes, including both qualitative and quantitative results for opioids, stimulants, benzodiazepines, alcohol, marijuana, hallucinogens, methadone, buprenorphine and norbuprenorphine.
|
Measured from baseline to 6-month follow-up
|
Six-Month Polysubstance Use Self Report
Time Frame: Assessed between the baseline assessment 6-month follow-up
|
The New York University (NYU) polysubstance use measurement tool will be utilized to assess polysubstance frequency.
|
Assessed between the baseline assessment 6-month follow-up
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Six-month OUD Treatment Retention
Time Frame: Measured from intake through 6-month follow up
|
Retention is measured using chart review of clinic records of appointment attendance.
Retention will be assessed measured as dichotomous retention (yes/no) at six months post MOUD initiation.
|
Measured from intake through 6-month follow up
|
Six-Month Problems Associated with Substance Use
Time Frame: Assessed between the baseline assessment and 6-month follow-up
|
Problems associated with use will be assessed using the Short Inventory of Problems (SIP), a 15-item measure that will be used to assess five domains of impairment related to polysubstance use.
|
Assessed between the baseline assessment and 6-month follow-up
|
Six-month Buprenorphine Adherence
Time Frame: Measured from intake to six-month follow-up
|
Buprenorphine adherence will be assessed through urinalysis.
Urine samples are collected at each visit and sent out for toxicological analysis using a customized panel composed of 40 analytes, including both qualitative and quantitative results for opioids, stimulants, benzodiazepines, alcohol, marijuana, hallucinogens, methadone, buprenorphine and norbuprenorphine.
Continuity of pharmacy for MOUD through 6 months will be assessed and calculated via the percent retained on MT for at least 6 months, defined as having one or more additional MOUD-related visits for each 30-day period up to 6 months.
|
Measured from intake to six-month follow-up
|
Intervention Uptake
Time Frame: Assessed between the baseline assessment and 6-month follow-up
|
Feasibility, defined as the suitability and practicability of the approach, will be measured quantitatively as the % of patients who agree to participate in the intervention.
|
Assessed between the baseline assessment and 6-month follow-up
|
Intervention Session Attendance
Time Frame: Assessed between the baseline assessment 6-month follow-up
|
Acceptability, defined as satisfaction with or tolerability of the proposed approach, will be measured quantitatively by session attendance.
Specifically, % of patients enrolled who attend ≥75% sessions will be measured.
|
Assessed between the baseline assessment 6-month follow-up
|
Intervention Fidelity
Time Frame: Assessed at the acute post-treatment follow-up (approximately 3-months post-baseline assessment)
|
Fidelity, defined as the delivery of the intervention as intended, will be measured based on PRS adherence to the intervention delivery.
A random selection of 20% of sessions will be rated for fidelity by an independent rater, and % of intervention components delivered as intended will be measured.
|
Assessed at the acute post-treatment follow-up (approximately 3-months post-baseline assessment)
|
Six-month Self-Report Buprenorphine Adherence
Time Frame: Assessed between the baseline assessment and 6-month follow-up
|
The IRA Wilson will be utilized to assess self-report buprenorphine adherence
|
Assessed between the baseline assessment and 6-month follow-up
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Three-month OUD Treatment Retention
Time Frame: Measured from intake through 3-month follow up
|
Retention is measured using chart review of clinic records of appointment attendance.
Retention will be assessed measured as dichotomous retention (yes/no) at three months post MOUD initiation.
|
Measured from intake through 3-month follow up
|
Three-Month Polysubstance Use Urinalysis
Time Frame: Measured from baseline to 3-month follow-up.
|
Polysubstance use will be assessed using urinalysis.
Urine samples are collected at each visit and sent out for toxicological analysis using a customized panel composed of 40 analytes, including both qualitative and quantitative results for opioids, stimulants, benzodiazepines, alcohol, marijuana, hallucinogens, methadone, buprenorphine and norbuprenorphine.
|
Measured from baseline to 3-month follow-up.
|
Three-Month Polysubstance Use Self Report
Time Frame: Measured from baseline to 3-month follow-up.
|
The New York University (NYU) polysubstance use measurement tool will be utilized to assess polysubstance frequency.
|
Measured from baseline to 3-month follow-up.
|
Three-Month Problems Associated with Substance Use
Time Frame: Assessed between baseline assessment and 3-month follow-up.
|
Problems associated with use will be assessed using the Short Inventory of Problems (SIP), a 15-item measure that will be used to assess five domains of impairment related to polysubstance use.
|
Assessed between baseline assessment and 3-month follow-up.
|
Three-month Buprenorphine Adherence
Time Frame: Measured over 3 months
|
Buprenorphine adherence will be assessed through urinalysis.
Urine samples are collected at each visit and sent out for toxicological analysis using a customized panel composed of 40 analytes, including both qualitative and quantitative results for opioids, stimulants, benzodiazepines, alcohol, marijuana, hallucinogens, methadone, buprenorphine and norbuprenorphine.
Continuity of pharmacy for MOUD through 3 months will be assessed and calculated via the percent retained on MT for at least 3 months, defined as having one or more additional MOUD-related visits for each 30-day period up to 3 months.
|
Measured over 3 months
|
Twelve-month OUD Treatment Retention
Time Frame: Measured from intake through 12-month follow up
|
Retention is measured using chart review of clinic records of appointment attendance.
Retention will be assessed measured as dichotomous retention (yes/no) at twelve months post MOUD initiation.
|
Measured from intake through 12-month follow up
|
Twelve-Month Polysubstance Use Urinalysis
Time Frame: Measured from baseline to 12-month follow-up.
|
Polysubstance use will be assessed using urinalysis.
Urine samples are collected at each visit and sent out for toxicological analysis using a customized panel composed of 40 analytes, including both qualitative and quantitative results for opioids, stimulants, benzodiazepines, alcohol, marijuana, hallucinogens, methadone, buprenorphine and norbuprenorphine.
|
Measured from baseline to 12-month follow-up.
|
Twelve-Month Polysubstance Use Self Report
Time Frame: Measured from baseline to 12-month follow-up.
|
The New York University (NYU) polysubstance use measurement tool will be utilized to assess polysubstance frequency.
|
Measured from baseline to 12-month follow-up.
|
Twelve-Month Problems Associated with Substance Use
Time Frame: Assessed between the baseline and 12-month follow-up.
|
Problems associated with use will be assessed using the Short Inventory of Problems (SIP), a 15-item measure that will be used to assess five domains of impairment related to polysubstance use.
|
Assessed between the baseline and 12-month follow-up.
|
Twelve-month Buprenorphine Adherence
Time Frame: Measured over 12 months
|
Buprenorphine adherence will be assessed through urinalysis.
Urine samples are collected at each visit and sent out for toxicological analysis using a customized panel composed of 40 analytes, including both qualitative and quantitative results for opioids, stimulants, benzodiazepines, alcohol, marijuana, hallucinogens, methadone, buprenorphine and norbuprenorphine.
Continuity of pharmacy for MOUD through 12 months will be assessed and calculated via the percent retained on MT for at least 12 months, defined as having one or more additional MOUD-related visits for each 30-day period up to 12 months.
|
Measured over 12 months
|
Six-month Treatment Cost
Time Frame: Measured from baseline to 6-month follow-up
|
The resources required to implement and sustain the interventions (Peer Activate-MTU, and ETAU) will be identified via micro-costing techniques, using a tailored version of the Drug Abuse Treatment Cost Analysis Program (DATCAP) instrument, a standardized, customizable tool designed to capture intervention resources in multiple settings for the purpose of estimating costs.
|
Measured from baseline to 6-month follow-up
|
Six-month Healthcare Resource Utilization
Time Frame: Measured from baseline to 6-month follow-up
|
Healthcare Resource Utilization by participants will be self-reported using time-anchoring methodology via the Non-study Medical and Other Services (NMOS) form, and will include non-study MOUD care, inpatient, outpatient, and emergency department services; SUD treatment medications; residential and outpatient SUD treatment days; hospital SUD detoxification days; and mental health treatment.
|
Measured from baseline to 6-month follow-up
|
Six-month Health-related Quality of Life
Time Frame: Measured from baseline to 6-month follow-up
|
Health-related quality of life (HRQoL) will be measured using the Patient-Reported Outcomes Measurement Information System (PROMIS)-Preference (PROPr) instrument.
|
Measured from baseline to 6-month follow-up
|
Six-month Non-Medical and Other Resource Utilization
Time Frame: Measured from baseline to 6-month follow-up
|
Use of non-medical and other resources from the societal perspective (e.g., school/workplace productivity, travel time to care, caregiver burden, etc.) will also be self-reported using the NMOS.
|
Measured from baseline to 6-month follow-up
|
Six-month Criminal and Legal Activities
Time Frame: Measured from baseline to 6-month follow-up
|
Criminal and legal activities will be measured using the time-anchoring methodology via the Criminal-Legal Activities Form (CLAF).
|
Measured from baseline to 6-month follow-up
|
Overdose risk
Time Frame: Measured from baseline to 6-month follow-up
|
Overdose risk will be assessed as a binary outcome (including both fatal and non-fatal overdoses).
|
Measured from baseline to 6-month follow-up
|
Three-month Self-Report Buprenorphine Adherence
Time Frame: Assessed between the baseline assessment and 3-month follow-up
|
The IRA Wilson will be utilized to assess self-report buprenorphine adherence
|
Assessed between the baseline assessment and 3-month follow-up
|
Twelve-month Self-Report Buprenorphine Adherence
Time Frame: Assessed between the baseline assessment and 12-month follow-up
|
The IRA Wilson will be utilized to assess self-report buprenorphine adherence
|
Assessed between the baseline assessment and 12-month follow-up
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Jessica F Magidson, PhD, University of Maryland, College Park
- Principal Investigator: Sarah M Kattakuzhy, MD, University of Maryland, Baltimore
Publications and helpful links
General Publications
- Glasgow RE, Vogt TM, Boles SM. Evaluating the public health impact of health promotion interventions: the RE-AIM framework. Am J Public Health. 1999 Sep;89(9):1322-7. doi: 10.2105/ajph.89.9.1322.
- Richards DA, Ekers D, McMillan D, Taylor RS, Byford S, Warren FC, Barrett B, Farrand PA, Gilbody S, Kuyken W, O'Mahen H, Watkins ER, Wright KA, Hollon SD, Reed N, Rhodes S, Fletcher E, Finning K. Cost and Outcome of Behavioural Activation versus Cognitive Behavioural Therapy for Depression (COBRA): a randomised, controlled, non-inferiority trial. Lancet. 2016 Aug 27;388(10047):871-80. doi: 10.1016/S0140-6736(16)31140-0. Epub 2016 Jul 23.
- Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, Griffey R, Hensley M. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Adm Policy Ment Health. 2011 Mar;38(2):65-76. doi: 10.1007/s10488-010-0319-7.
- Carroll KM. Lost in translation? Moving contingency management and cognitive behavioral therapy into clinical practice. Ann N Y Acad Sci. 2014 Oct;1327(1):94-111. doi: 10.1111/nyas.12501. Epub 2014 Sep 9.
- Daughters SB, Magidson JF, Anand D, Seitz-Brown CJ, Chen Y, Baker S. The effect of a behavioral activation treatment for substance use on post-treatment abstinence: a randomized controlled trial. Addiction. 2018 Mar;113(3):535-544. doi: 10.1111/add.14049. Epub 2017 Nov 19.
- Daughters SB, Magidson JF, Schuster RM, Safren SA. ACT HEALTHY: A Combined Cognitive-Behavioral Depression and Medication Adherence Treatment for HIV-Infected Substance Users. Cogn Behav Pract. 2010 Aug 1;17(3):309-321. doi: 10.1016/j.cbpra.2009.12.003.
- Magidson JF, Gorka SM, MacPherson L, Hopko DR, Blanco C, Lejuez CW, Daughters SB. Examining the effect of the Life Enhancement Treatment for Substance Use (LETS ACT) on residential substance abuse treatment retention. Addict Behav. 2011 Jun;36(6):615-623. doi: 10.1016/j.addbeh.2011.01.016. Epub 2011 Jan 21.
- Magidson JF, Seitz-Brown CJ, Safren SA, Daughters SB. Implementing Behavioral Activation and Life-Steps for Depression and HIV Medication Adherence in a Community Health Center. Cogn Behav Pract. 2014 Nov 1;21(4):386-403. doi: 10.1016/j.cbpra.2013.10.002.
- Magidson JF, Lejuez CW, Kamal T, Blevins EJ, Murray LK, Bass JK, Bolton P, Pagoto S. Adaptation of community health worker-delivered behavioral activation for torture survivors in Kurdistan, Iraq. Glob Ment Health (Camb). 2015 Dec;2:e24. doi: 10.1017/gmh.2015.22.
- Mimiaga MJ, Reisner SL, Pantalone DW, O'Cleirigh C, Mayer KH, Safren SA. A pilot trial of integrated behavioral activation and sexual risk reduction counseling for HIV-uninfected men who have sex with men abusing crystal methamphetamine. AIDS Patient Care STDS. 2012 Nov;26(11):681-93. doi: 10.1089/apc.2012.0216. Epub 2012 Oct 3.
- Tull MT, Berghoff CR, Bardeen JR, Schoenleber M, Konkle-Parker DJ. An Initial Open Trial of a Brief Behavioral Activation Treatment for Depression and Medication Adherence in HIV-Infected Patients. Behav Modif. 2018 Mar;42(2):196-209. doi: 10.1177/0145445517723901. Epub 2017 Aug 11.
- Ghertner R. U.S. trends in the supply of providers with a waiver to prescribe buprenorphine for opioid use disorder in 2016 and 2018. Drug Alcohol Depend. 2019 Nov 1;204:107527. doi: 10.1016/j.drugalcdep.2019.06.029. Epub 2019 Aug 30.
- Mimiaga MJ, Pantalone DW, Biello KB, Hughto JMW, Frank J, O'Cleirigh C, Reisner SL, Restar A, Mayer KH, Safren SA. An initial randomized controlled trial of behavioral activation for treatment of concurrent crystal methamphetamine dependence and sexual risk for HIV acquisition among men who have sex with men. AIDS Care. 2019 Sep;31(9):1083-1095. doi: 10.1080/09540121.2019.1595518. Epub 2019 Mar 19.
- Magidson JF, Joska JA, Regenauer KS, Satinsky E, Andersen LS, Seitz-Brown CJ, Borba CPC, Safren SA, Myers B. "Someone who is in this thing that I am suffering from": The role of peers and other facilitators for task sharing substance use treatment in South African HIV care. Int J Drug Policy. 2019 Aug;70:61-69. doi: 10.1016/j.drugpo.2018.11.004. Epub 2019 May 10.
- Mack KA, Jones CM, Ballesteros MF. Illicit Drug Use, Illicit Drug Use Disorders, and Drug Overdose Deaths in Metropolitan and Nonmetropolitan Areas-United States. Am J Transplant. 2017 Dec;17(12):3241-3252. doi: 10.1111/ajt.14555.
- Langabeer JR, Stotts AL, Cortez A, Tortolero G, Champagne-Langabeer T. Geographic proximity to buprenorphine treatment providers in the U.S. Drug Alcohol Depend. 2020 Aug 1;213:108131. doi: 10.1016/j.drugalcdep.2020.108131. Epub 2020 Jun 24.
- Magidson JF, Kleinman MB, Bradley V, Anvari MS, Abidogun TM, Belcher AM, Greenblatt AD, Dean D, Hines A, Seitz-Brown CJ, Wagner M, Bennett M, Felton JW. Peer recovery specialist-delivered, behavioral activation intervention to improve retention in methadone treatment: Results from an open-label, Type 1 hybrid effectiveness-implementation pilot trial. Int J Drug Policy. 2022 Oct;108:103813. doi: 10.1016/j.drugpo.2022.103813. Epub 2022 Aug 3.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1953327
- R01DA057443 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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