- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05988944
The Hand Functions In Cerebral Palsy
March 12, 2024 updated by: Cetin Sayaca, Uludag University
Which One is The Most Effective On The Hand Functions In Cerebral Palsy: Constraint-Induced Movement Therapy or Constraint-Induced Movement Therapy With Virtual Reality? A Randomized Controlled Trial.
The hand motor functions are very important in the daily life activities, educational, and social participation of children.
Losing The hand motor functions limit these activities and participation.
Constraint-induced movement therapy (CIMT) or virtual reality (VR) therapy has often been preferred to improve the hand's motor functions.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
CIMT and VR are used to improve the motor functions of the hand in cerebral palsy (CP).
The aim of this study was to compare the effects of CIMT-VR use and only CIMT use on hand functions in children with hemiparetic cerebral palsy.
Hand function and performance were evaluated with the Jebsen-Taylor and Moberg pick-up tests.
All evaluations were made twice; before the first therapy and after six weeks.
Children with hemiparetic CP were divided into three groups randomly (Traditional techniques (TT), TT+CIMT, and TT+CIMT+VR).
Study Type
Interventional
Enrollment (Actual)
45
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Cetin Sayaca, Assoc. Prof.
- Phone Number: +90 543 621 8023
- Email: cetinsayaca@uludag.edu.tr
Study Locations
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Istanbul, Turkey
- Uskudar Universty
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
Accepts Healthy Volunteers
No
Description
The inclusion criteria of the study were determined to be
- aged 8 to 18 years,
- diagnosed with hemiparetic CP,
- being level 2 or 3 according to the gross motor function measurement scale and the manual ability classification system.
The exclusion criteria of the study were,
- severe cognitive dysfunction that rendered them unable to perform simple tasks (e.g., reaching, grasping),
- having pharmacologic medicine for spasticity,
- having botulinum toxin A injections in the last 6 months,
- having upper extremity surgery,
- having visual and/or auditory problems which affect therapy or evaluation.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Traditional techniques
TT was planned according to the child's hand that was needed.
Neurodevelopmental facilitation techniques (Bobath therapy), stretching, and grasping types (cylindrical, spherical, hook, key, fingertip, lateral) were used in hands therapy for 45 minutes two days in a week for all children who were accepted to participate in this study.
|
TT: Traditional Techniques
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Experimental: traditional therapy with constraint induced movement therapy
The sling was put on the child's non-paretic arm to apply CIMT.
The around of the sling was sewn except the elbow and secured snugly to the trunk with a waist strap to prevent assisting the affected hand during the application of CIMT.
However, children with CP who were in the this group used the sling for three hours in daily activity, playing, etc. at home.
The CIMT was given as a home program and monitorization was done by the follow-up form every week with no therapy during the weekend.
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TT: Traditional Techniques CIMT: constraint-induced movement therapy
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Experimental: traditional therapy with constraint induced movement therapy and virtual reality
After the TT session, a child with CP used the sling for 45 minutes at the rehabilitation center with VR therapy.
VR therapy with CIMT was used in hands therapy for 45 minutes at two days a week after TT.
During the VR therapy, the child was encouraged verbally to play X-box.The X-box Kinect 360 (by the Microsoft corporation) was used for VR therapy.
It has a kinetic sensor that perceives the movement of the child with CP.
The child's movement can be seen through the monitor in real time.
VR does not need special buttons to play.
Therefore, a child with CP who had impaired fine motor skills and dexterity can play easily.
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TT: Traditional Techniques CIMT: constraint-induced movement therapy VR: virtual reality
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The Jebsen-Taylor Test
Time Frame: this evaluation was done twice; before the first therapy and after six weeks by the same physiotherapist.
|
The Jebsen-Taylor Test is a reliable tool that evaluates the hand function of children with CP.
The test includes seven items.
These items are; writing a 24-letter sentence, turning over five cards, picking up small objects (two pieces of pennies/bottle caps/paperclips), simulated feeding (using a teaspoon and five kidney beans), stacking four checkers, picking up and moving five large empty tin boxes and then five large full boxes.
During the assessment, the child with CP was seated in front of a table and test was performed by hemiparetic hand.
Time was recorded on each item by stopwatch.
The total score was calculated by collecting all items' time.
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this evaluation was done twice; before the first therapy and after six weeks by the same physiotherapist.
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Moberg pick-up test
Time Frame: this evaluation was done twice; before the first therapy and after six weeks by the same physiotherapist.
|
To evaluate the functional performance of the hemiparetic hand Moberg pick-up test (MPUT) was used.
MPUT consists of twelve items which are a wing nut, screw, key, nail, ₺1 coin, 50 kurus coin, washer, safety pin, paper clip, large and medium-sized hexagonal nut, and small square nut.
The plastic container (60x30 cm) was placed lengthwise about 15 cm from the edge of the table on the opposite side of the items.
The child was seated in a chair.
The hemiparetic hand of children with CP was put on the same side as the 12 items which were randomly placed on the table.
Children with CP were ordered to pick up the items one at a time and place them into the plastic container as fast as possible.
The time was recorded with a stopwatch.
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this evaluation was done twice; before the first therapy and after six weeks by the same physiotherapist.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Chair: Esin KADIKOYLU, Pt, Uskudar University
- Study Chair: Eren DEMIRAYAK, Pt, Uskudar University
- Principal Investigator: Cetin Sayaca, Assoc. Prof., Uludag University
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Sakzewski L, Ziviani J, Boyd R. Systematic review and meta-analysis of therapeutic management of upper-limb dysfunction in children with congenital hemiplegia. Pediatrics. 2009 Jun;123(6):e1111-22. doi: 10.1542/peds.2008-3335. Epub 2009 May 18.
- Brady K, Garcia T. Constraint-induced movement therapy (CIMT): pediatric applications. Dev Disabil Res Rev. 2009;15(2):102-11. doi: 10.1002/ddrr.59.
- Hoare BJ, Wallen MA, Thorley MN, Jackman ML, Carey LM, Imms C. Constraint-induced movement therapy in children with unilateral cerebral palsy. Cochrane Database Syst Rev. 2019 Apr 1;4(4):CD004149. doi: 10.1002/14651858.CD004149.pub3.
- Elliott C, Reid S, Hamer P, Alderson J, Elliott B. Lycra((R)) arm splints improve movement fluency in children with cerebral palsy. Gait Posture. 2011 Feb;33(2):214-9. doi: 10.1016/j.gaitpost.2010.11.008. Epub 2010 Dec 4.
- Jung SH, Song SH, Kim SD, Lee K, Lee GC. Does virtual reality training using the Xbox Kinect have a positive effect on physical functioning in children with spastic cerebral palsy? A case series. J Pediatr Rehabil Med. 2018;11(2):95-101. doi: 10.3233/PRM-160415.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 13, 2023
Primary Completion (Actual)
March 10, 2024
Study Completion (Actual)
March 12, 2024
Study Registration Dates
First Submitted
August 4, 2023
First Submitted That Met QC Criteria
August 4, 2023
First Posted (Actual)
August 14, 2023
Study Record Updates
Last Update Posted (Actual)
March 13, 2024
Last Update Submitted That Met QC Criteria
March 12, 2024
Last Verified
March 1, 2024
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CIMT vs VR
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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