Effect of Hyperbaric Oxygen Therapy

October 26, 2023 updated by: University Medical Centre Ljubljana

Effect of Hyperbaric Oxygen Therapy Has no Acute Effects on Recovery and Performance After a Football Match

The goal of this tudy will be to investigate the effects of a single session of hyperbaric oxygen therapy (HBOT) on recovery and performance after a football match in elite youth football players.

The main questions this study will aim to answer are:

Will a single session of HBOT improve recovery parameters such as biochemical markers and physical fitness in elite youth football players after a football match? Will a single session of HBOT enhance the performance of elite youth football players after a football match?

Participants in this study will include twenty elite youth male football players. They will be randomly assigned to either the HBOT group or the control group. All participants will undergo evaluations for biochemical parameters, physical fitness tests, and the Hooper Index (HI) at multiple time points: before the match, at the end of the match, one hour after the HBOT session, and 12 hours after the HBOT session.

In the HBOT group, participants will receive 100% oxygen under elevated pressure in a hyperbaric chamber for a duration of 70 minutes immediately after the football match. Meanwhile, the control group will be exposed to normal atmospheric pressure.

Biochemical analysis will involve collecting blood samples to measure markers such as myoglobin, creatine kinase, lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase. Physical fitness tests will include vertical jump height measurements (squat jump, countermovement jump, and countermovement jump with arm swing) and linear speed assessments at various distances (5 m, 10 m, and 20 m). The Hooper Index (HI) will be used for subjective assessment of fatigue and well-being.

This study aims to provide insights into the potential benefits of HBOT as a recovery strategy for elite youth football players and its impact on performance in the future.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Serbia
      • Subotica, Serbia
        • Hyperbaric center Subotica

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • football player
  • free of injuries
  • free of medical conditions contraindicated by hyperbaric oxygen therapy (HBOT)
  • written parental consent

Exclusion Criteria:

  • pre-existing injuries or medical conditions that are contraindicated by hyperbaric oxygen therapy (HBOT)
  • participation in severe physical activity within 24 hours before the study
  • participants who do not comply with the requirement to abstain from breakfast, caffeine, and alcohol prior to the first blood collection
  • an active respiratory illness, such as a cold, at the time of the study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: HBOT group
Other: HBOT group
The HBOT will be performed in a Barox HBOT chamber (Yaklasim Makina San. Ve Tic. Ltd. Sti). Participants will be taken to the chamber immediately after the football match, where they will sit in individual chairs, and oxygen will be delivered through individual masks. The HBOT group will be exposed to 100% oxygen at 2.2 ATA (atmospheres absolute). Session will last 70 minutes.
Placebo Comparator: CON group
Other: CON group
The placebo protocols will be performed in a Barox HBOT chamber (Yaklasim Makina San. Ve Tic. Ltd. Sti). Participants will be taken to the chamber immediately after the football match, where they will sit in individual chairs, and oxygen will be delivered through individual masks. The CON group will be exposed to normobaric ambient pressure (1 ATA). The session will last 70 minutes.
Other Names:
  • Placebo
  • Control

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Myoglobin
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of myoglobin concentration in blood. Myoglobin will be determined using Siemens IMMULITE 1000 (Siemens Healthcare Diagnostics, UK).
baseline, 3 hours, 5 hours, 24 hours
Creatine kinase
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of creatine kinase concentration in blood. It will be analyzed using a biochemistry analyzer (A25 Biosystems Chemistry Analyzer).
baseline, 3 hours, 5 hours, 24 hours
Lactate dehydrogenase
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of lactate dehydrogenase concentration in blood. It will be analyzed using a biochemistry analyzer (A25 Biosystems Chemistry Analyzer).
baseline, 3 hours, 5 hours, 24 hours
Alanine aminotransferase
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of alanine aminotransferase concentration in blood. It will be analyzed using a biochemistry analyzer (A25 Biosystems Chemistry Analyzer).
baseline, 3 hours, 5 hours, 24 hours
Aspartate aminotransferase
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of aspartate aminotransferase concentration in blood. It will be analyzed using a biochemistry analyzer (A25 Biosystems Chemistry Analyzer).
baseline, 3 hours, 5 hours, 24 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Squat jump
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of a squat jump height in cm. The squat jump will be performed in a semi-squat position with the knees bent at 90 degrees and the arms resting on the hips. Participants will hold this stance for one to three seconds before executing a maximal vertical jump.
baseline, 3 hours, 5 hours, 24 hours
Countermovement jump
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of a countermovement jump height in cm. It will be evaluated with participants standing straight up, distributing their weight equally over both feet. The arms will be secured to the hips to prevent their influence on jump height. Participants will then squat down to a 90-degree flexion and execute a maximal vertical jump without pausing during the change of direction.
baseline, 3 hours, 5 hours, 24 hours
Countermovement jump with arm swing
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of a countermovement jump with arm swing height in cm. It will be evaluated with participants standing straight up, distributing their weight equally over both feet. During the jump, participants will have the freedom to move their arms.
baseline, 3 hours, 5 hours, 24 hours
5 meter linear speed
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of 5 meter linear speed. The Witty photocell system (Witty, System, Microgate, Bolzano, Italy) will be utilized to evaluate performance. These photocells will be positioned 0.4 meters above the ground and will provide measurements with an accuracy of 0.001 meters per second.
baseline, 3 hours, 5 hours, 24 hours
10 meter linear speed
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of 10 meter linear speed. The Witty photocell system (Witty, System, Microgate, Bolzano, Italy) will be utilized to evaluate performance. These photocells will be positioned 0.4 meters above the ground and will provide measurements with an accuracy of 0.001 meters per second.
baseline, 3 hours, 5 hours, 24 hours
20 meter linear speed
Time Frame: baseline, 3 hours, 5 hours, 24 hours
Measure of 20 meter linear speed. The Witty photocell system (Witty, System, Microgate, Bolzano, Italy) will be utilized to evaluate performance. These photocells will be positioned 0.4 meters above the ground and will provide measurements with an accuracy of 0.001 meters per second.
baseline, 3 hours, 5 hours, 24 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Medical Centre Ljubljana

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 20, 2023

Primary Completion (Actual)

June 4, 2023

Study Completion (Actual)

June 6, 2023

Study Registration Dates

First Submitted

October 18, 2023

First Submitted That Met QC Criteria

October 26, 2023

First Posted (Actual)

November 1, 2023

Study Record Updates

Last Update Posted (Actual)

November 1, 2023

Last Update Submitted That Met QC Criteria

October 26, 2023

Last Verified

October 1, 2023

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • HBstudy

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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