Prognostic Factors Influencing the Recurrence Rate and Survival of Patients With Colorectal Cancer: a Single Institution Experience

over the past decade colon cancer has emerged as the second most deadly and the third most common type of cancer in the world with increasing incidence in Egypt due to life style and diet change. some research showed relation between colon cancer recurrence and advanced tumor staging. To investigators knowledge, this is the first time to be done in Zagazig University.

Data was collected from records in a retrospective cohort study

Study Overview

• Status: Completed
• Conditions: Colorectal Cancer
• Intervention / Treatment: Procedure: resection of colorectal cancer

• Study Type: Observational
• Enrollment (Actual): 200

Contacts and Locations

Study Locations

• Egypt
  • Zagazig, Egypt, 44519
    • Zagazig University Hospitals

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Probability Sample

Study Population

patient with newely diagnosed colorectal cancer were followed up after surgery to detect if there was a recurrence prospectively, while patients with recurrent colorectal cancer were studied retrospectively to find out factors influencing the recurrence

Description

Inclusion Criteria:

• Adult patients with newly diagnosed colorectal cancer
• Age > 18 years old
• recurrent cases of colorectal cancer

Exclusion Criteria:

• Pediartric patient less than 18 yr
• In operable or metastatic cancer colon
• No other malignancies

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
age	age of patients was obtained from medical records	through study completion, an average of 5 years
sex	sex of patients was obtained from medical records	through study completion, an average of 5 years
medical disease	co-existing medical disease was obtained from medical records	through study completion, an average of 5 years
previous surgery	previous surgical history was obtained from medical records	through study completion, an average of 5 years
CEA	value of carcino-embryonic antigen was recorded	through study completion, an average of 5 years
tumor grade	tumor grade after resection from pathology report recorded	through study completion, an average of 5 years
tumor site	tumor site recorded from operative findings	through study completion, an average of 5 years
tumor size	tumor size was measured by length x width in cm from records	through study completion, an average of 5 years
surgical margins of resected tumor	safety margins were assessed from pathological examination under microscopy and recorded in pathology reports, it can be free surgical margins ( no tumor cells) or positive surgical margins( presence of tumor cells)	through study completion, an average of 5 years
neoadjuvant therapy	history of neoadjuvant therapy before surgery from records obtained	through study completion, an average of 5 years
adjuvant therapy	history of adjuvant therapy post operative obtained from records	through study completion, an average of 5 years
diet	diet and dietary life style from history	through study completion, an average of 5 years
occupation	occupation of the patient at time of surgery and if it was changed	through study completion, an average of 5 years
family history	history taking of family history of cancer disease	through study completion, an average of 5 years
type of surgery(laparoscopic or open)	type of operation was laparoscopic or open surgery obtained from records	through study completion, an average of 5 years
soiling by during surgery	by history from records if there was soiling of the field by tumor cells	through study completion, an average of 5 years
hand sewen or stappled anastmosis	if there was bowel re-anastmosis after surgery, it was done using a stappler or hand sewing sutures. this was obtained from operative data in patient records	through study completion, an average of 5 years
post operative complications	from records; if there were post operative complication like fecal fistula	through study completion, an average of 5 years
site of recurrence	site of tumor recurrence was detected	through study completion, an average of 5 years
type of resected tumor	type of tumor was recorded from pathology reports	through study completion, an average of 5 years

Collaborators and Investigators

• Sponsor: Zagazig University
• Investigators: Principal Investigator: Reham Zakaria, PhD, faculty of medicine Zagazig University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2013
• Primary Completion (Actual): December 1, 2022
• Study Completion (Actual): December 1, 2022

Study Registration Dates

• First Submitted: March 11, 2024
• First Submitted That Met QC Criteria: March 15, 2024
• First Posted (Actual): March 22, 2024

Study Record Updates

• Last Update Posted (Actual): March 22, 2024
• Last Update Submitted That Met QC Criteria: March 15, 2024
• Last Verified: March 1, 2024

More Information

Terms related to this study

• Keywords: cancer; prognosis; colorectal; recurrence
• Additional Relevant MeSH Terms: Digestive System Diseases; Pathologic Processes; Neoplasms; Neoplasms by Site; Disease Attributes; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms; Recurrence
• Other Study ID Numbers: #11279-20-11-2023

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: data will be available on demand by contacting the principle investigator

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No